Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing.
Hetzler PT, Dash BC, Guo S, Hsia HC. Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing. Annals Of Plastic Surgery 2019, 83: e92-e95. PMID: 31246672, PMCID: PMC6851445, DOI: 10.1097/sap.0000000000001955.Peer-Reviewed Original ResearchConceptsTherapeutic targetAberrant wound healing processAppropriate physiologic responseMorbid disease processSurvival of myofibroblastsWound healingFibrotic signaling pathwaysTranscription factor/serum response factor (MRTF/SRF) pathwayFuture therapeutic targetsSmooth muscle actinFuture translational researchCurrent literatureFibrotic signalingTherapeutic optionsFibrotic lesionsTissue injuryWound healing processDisease processPhysiologic responsesSerum response factor pathwayMuscle actinFactor pathwayExcessive responseFibrosisTranslational researchThe potential and limitations of induced pluripotent stem cells to achieve wound healing
Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A. The potential and limitations of induced pluripotent stem cells to achieve wound healing. Stem Cell Research & Therapy 2019, 10: 87. PMID: 30867069, PMCID: PMC6416973, DOI: 10.1186/s13287-019-1185-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic woundsCell therapyStem cellsDiabetic foot ulcersCell typesWound healingInvasive harvesting techniquesAdult-derived stem cellsNormal skin architecturePluripotent stem cellsLimb ischemiaFoot ulcersLimited cell survivalSafety profileOnly cell typeAnimal modelsHuman studiesPotential treatmentPhysiologic responsesHealthy skinImmune rejectionAdvanced therapiesTranslational potentialUse of iPSCsSystemic factors