1991
The excitotoxin hypothesis in relation to cerebral ischemia.
Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsSelective neuronal deathExcitotoxin hypothesisNeuronal deathExtracellular glutamate concentration increasesSelective vulnerable brain regionsBrain regionsN-methyl-D-aspartate receptorsGlutamate accumulationBrain cell injuryVulnerable brain regionsTransient global ischemiaHigh-performance liquid chromatographyDistinct brain regionsNeuronal injuryBrain extracellular spaceCerebral ischemiaTransient ischemiaAntagonist APVExcitatory neurotransmitterGlobal ischemiaExtracellular glutamateNMDA antagonistsCertain neuronsMicrodialysis technique
1988
Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia
Benveniste H, Jørgensen M, Diemer N, Hansen A. Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia. Acta Neurologica Scandinavica 1988, 78: 529-536. PMID: 2906199, DOI: 10.1111/j.1600-0404.1988.tb03697.x.Peer-Reviewed Original ResearchConceptsGlutamate N-methyl-D-aspartate receptorN-methyl-D-aspartate receptorsCell damageNerve cell destructionComplete cerebral ischemiaBrain cell damageMin of ischemiaOnset of ischemiaHippocampal cell damageGlutamate receptor activationCA 1 regionRole of intracellularCerebral ischemiaIschemic periodBilateral destructionDenervated hippocampusAfferent inputSynaptic transmissionCalcium influxIschemiaCompetitive antagonistReceptor activationHistological studyCell destructionCalcium accumulationMagnesium Inhibits Ischemia Induced Calcium Accumulation in Hilar Neurones: Possible Effect of Nmda-Receptor
Benveniste H, Diemer N. Magnesium Inhibits Ischemia Induced Calcium Accumulation in Hilar Neurones: Possible Effect of Nmda-Receptor. Advances In Behavioral Biology 1988, 35: 377-377. DOI: 10.1007/978-1-4684-5562-5_40.Peer-Reviewed Original ResearchHilar neuronsCA 1 pyramidal cellsN-methyl-D-aspartate receptorsCalcium accumulationIschemic brain damageExcessive calcium accumulationIschemic changesIschemic damageBrain damageNMDA receptorsPyramidal cellsSelective vulnerabilityHilar neuronesCalcium influxIrreversible morphological changesCalcium conductanceIschemiaMorphological damageExcessive accumulationNeuronsPivotal roleMorphological changesHoursPossible effectsDamage