2014
Chapter Six The Role of Guanfacine as a Therapeutic Agent to Address Stress-Related Pathophysiology in Cocaine-Dependent Individuals
Fox H, Sinha R. Chapter Six The Role of Guanfacine as a Therapeutic Agent to Address Stress-Related Pathophysiology in Cocaine-Dependent Individuals. Advances In Pharmacology 2014, 69: 217-265. PMID: 24484979, PMCID: PMC4017947, DOI: 10.1016/b978-0-12-420118-7.00006-8.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsAdaptive goal-directed behaviorNegative emotional statesGoal-directed behaviorCompulsive drug useDrug-seeking behaviorCocaine dependenceStress-related pathophysiologyCognitive regulationNegative affectEmotional controlEmotional statesAnxiety pathophysiologyPrefrontal cortexDrugs of abuseNeural systemsBehavioral processesRecent research findingsBrain regionsCocaine addictionGuanfacinePolydrug abusersResearch findingsCocaine withdrawal symptomsDrug use
2013
The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type
Fox HC, Sofuoglu M, Morgan PT, Tuit KL, Sinha R. The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type. Psychoneuroendocrinology 2013, 38: 1532-1544. PMID: 23374328, PMCID: PMC3772967, DOI: 10.1016/j.psyneuen.2012.12.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultAffectAlcohol DrinkingAnxietyArousalBlood PressureCocaine-Related DisordersComorbidityCuesDepressionDouble-Blind MethodEmotionsEstradiolFemaleHeart RateHumansHydrocortisoneHypothalamo-Hypophyseal SystemImagery, PsychotherapyMaleMiddle AgedPituitary-Adrenal SystemProgesteroneRelaxation TherapySex CharacteristicsSmokingStress, PsychologicalStroop TestConceptsDrug cravingCocaine-dependent menCognitive performanceStress arousalTreatment-seeking cocaine dependent individualsCue-induced cravingCocaine-dependent individualsCue typesStroop performanceSubjective cravingCognitive measuresImagery conditionNegative emotionsCue exposureInhibitory controlRelaxed moodDependent individualsDependent menArousal stateCravingArousalCounterbalanced orderStress exposureRewarding effectsCocaine dependence
2012
H. C. FOX ET AL.
Fox HC, D'Sa C, Kimmerling A, Siedlarz KM, Tuit KL, Stowe R, Sinha R. H. C. FOX ET AL. Human Psychopharmacology Clinical And Experimental 2012, 27: 156-166. PMID: 22389080, PMCID: PMC3674778, DOI: 10.1002/hup.1251.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsIL-10Dependent individualsSocial drinkersInterleukin-1 receptor antagonistTumor necrosis factor alphaElevated inflammatory stateAnti-inflammatory markersNecrosis factor alphaPro-inflammatory TNFαEffects of cocaineImmune system cytokinesChronic stress stateTreatment-seeking cocaine dependent individualsPeripheral cytokinesIL-1raInflammatory stateInterleukin-10Receptor antagonistFactor alphaSignificant elevationNovel biomarkersCocaine dependenceCocaine abusersSalivary cortisol