COVID-19 Vaccination in the First Trimester and Major Structural Birth Defects Among Live Births
Kharbanda E, DeSilva M, Lipkind H, Romitti P, Zhu J, Vesco K, Boyce T, Daley M, Fuller C, Getahun D, Jackson L, Williams J, Zerbo O, Weintraub E, Vazquez-Benitez G. COVID-19 Vaccination in the First Trimester and Major Structural Birth Defects Among Live Births. JAMA Pediatrics 2024, 178: 823-829. PMID: 38949821, PMCID: PMC11217887, DOI: 10.1001/jamapediatrics.2024.1917.Peer-Reviewed Original ResearchStructural birth defectsLive-born infantsFirst-trimesterBirth defectsCOVID-19 vaccineLive birthsRetrospective cohort study of singleton pregnanciesStudy of singleton pregnanciesVaccine exposureMessenger RNA COVID-19 vaccineMessenger RNAFirst-trimester vaccinationMRNA COVID-19 vaccinePrevent pregnancy complicationsRetrospective cohort studyStabilized inverse probability weightsElectronic health dataNeural tube defectsMedical record reviewMultisite cohort studyLMP dateVaccine Safety DatalinkCOVID-19 vaccine dosesSingleton pregnanciesEligible pregnanciesCoronavirus Disease 2019 (COVID-19) Vaccination and Stillbirth in the Vaccine Safety Datalink
Denoble A, Vazquez-Benitez G, Sheth S, Ackerman-Banks C, DeSilva M, Zhu J, Daley M, Getahun D, Klein N, Vesco K, Irving S, Nelson J, Williams J, Hambidge S, Donahue J, Weintraub E, Kharbanda E, Lipkind H. Coronavirus Disease 2019 (COVID-19) Vaccination and Stillbirth in the Vaccine Safety Datalink. Obstetrics And Gynecology 2024, 144: 215-222. PMID: 38843526, PMCID: PMC11250101, DOI: 10.1097/aog.0000000000005632.Peer-Reviewed Original ResearchVaccine Safety DatalinkAntepartum stillbirthVaccine Safety Datalink sitesLive birthsCOVID-19 vaccineVaccine dosePregnancy start dateRisk of severe morbidityRisk of stillbirthConditional logistic regressionCase-control studyVaccine manufacturersSingleton pregnanciesGestational ageFetal deathPostpartum visitMaternal ageIndex dateSevere morbidityDiagnostic codesPregnancyStillbirthPregnant peopleCOVID-19Logistic regressionObstetric Complications and Birth Outcomes After Antenatal Coronavirus Disease 2019 (COVID-19) Vaccination
Vesco K, Denoble A, Lipkind H, Kharbanda E, DeSilva M, Daley M, Getahun D, Zerbo O, Naleway A, Jackson L, Williams J, Boyce T, Fuller C, Weintraub E, Vazquez-Benitez G. Obstetric Complications and Birth Outcomes After Antenatal Coronavirus Disease 2019 (COVID-19) Vaccination. Obstetrics And Gynecology 2024, 143: 794-802. PMID: 38626447, PMCID: PMC11090513, DOI: 10.1097/aog.0000000000005583.Peer-Reviewed Original ResearchConceptsSmall-for-gestational ageMessenger RNA COVID-19 vaccineGestational diabetes mellitusRisk of adverse pregnancy outcomesAdverse pregnancy outcomesPreterm birthGestational hypertensionAdjusted hazard ratiosCOVID-19 vaccine dosesPregnancy outcomesCOVID-19 vaccineAssociated with small-for-gestational ageIncreased risk of adverse pregnancy outcomesVaccine doseRisk of preterm birthMessenger RNARetrospective cohort study of individualsMRNA COVID-19 vaccineWeeks of gestationRetrospective cohort studyHistory of COVID-19Cohort study of individualsVaccine Safety DatalinkSingleton pregnanciesUnexposed pregnanciesAbnormal uterine bleeding diagnoses and care following COVID-19 vaccination
Brooks N, Irving S, Kauffman T, Vesco K, Slaughter M, Smith N, Tepper N, Olson C, Weintraub E, Naleway A, Group V, DeNoble A, DeSilva M, Ellington S, Henninger M, Jazwa A, Kharbanda E, Lipkind H, Malden D, McNeil M, Tartof S, Zerbo O. Abnormal uterine bleeding diagnoses and care following COVID-19 vaccination. American Journal Of Obstetrics And Gynecology 2024, 230: 540.e1-540.e13. PMID: 38219855, DOI: 10.1016/j.ajog.2024.01.006.Peer-Reviewed Original ResearchAUB diagnosisAbnormal uterine bleedingAbnormal uterine bleeding casesUterine bleedingBleeding diagnosisAbnormal bleedingCOVID-19 vaccineChart reviewVaccinated patientsBleeding casesHealth system membersVaccination statusFemale patients of reproductive ageComparison of clinical characteristicsChart review of patientsPatients of reproductive ageProportion of Asian patientsDays of COVID-19 vaccinationReview of patientsVolume of bleedingProportion of patientsDemographic characteristics of patientsPost-COVID-19 vaccinationCharacteristics of patientsRace of patients