2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesDesign and analysis of longitudinal trials of antimicrobial use at the end of life: to give or not to give?
Juthani-Mehta M, Allore HG. Design and analysis of longitudinal trials of antimicrobial use at the end of life: to give or not to give? Therapeutic Advances In Drug Safety 2019, 10: 2042098618820210. PMID: 30800269, PMCID: PMC6378640, DOI: 10.1177/2042098618820210.Peer-Reviewed Original ResearchTerminal cancer patientsAntimicrobial useEnd of lifePalliative careCancer patientsLongitudinal trialBurden of medicationsCessation of medicationHealth literacy interventionsAntimicrobial therapyAntimicrobial prescribingHealth literacyTrial designComparative trial designTrial dataTrial periodMedicationsPatientsTrialsCareLongitudinal modelingLiteracy interventionsPrescribingTherapyInfection
2010
Gerontologic Biostatistics: The Statistical Challenges of Clinical Research with Older Study Participants
Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic Biostatistics: The Statistical Challenges of Clinical Research with Older Study Participants. Journal Of The American Geriatrics Society 2010, 58: 1386-1392. PMID: 20533963, PMCID: PMC2918405, DOI: 10.1111/j.1532-5415.2010.02926.x.Peer-Reviewed Original ResearchTrajectories of Disability in the Last Year of Life
Gill TM, Gahbauer EA, Han L, Allore HG. Trajectories of Disability in the Last Year of Life. New England Journal Of Medicine 2010, 362: 1173-1180. PMID: 20357280, PMCID: PMC2877372, DOI: 10.1056/nejmoa0909087.Peer-Reviewed Original ResearchConceptsCourse of disabilityDisability trajectoriesOrgan failureAdvanced dementiaSudden deathOlder personsSevere disabilityCommunity-dwelling older personsTrajectories of disabilityLevel of disabilityCatastrophic disabilityEnd of lifeProgressive disabilityFunctional statusDeath certificatesCommon conditionBaseline assessmentPredominant trajectoriesMonthly interviewsDeathDisabilityLongitudinal studyDementiaFrailtyDecedents