2010
OC-052 Assessment of novel genetic polymorphisms and risk of upper gastrointestinal carcinoma
Hold G, El-Omar E, Chow W, Risch H, Gammon M, Vaughan T, Lissowska J, Lochhead P, Rabkin C, Ng M. OC-052 Assessment of novel genetic polymorphisms and risk of upper gastrointestinal carcinoma. Gut 2010, 59: a21. DOI: 10.1136/gut.2009.208959z.Peer-Reviewed Original ResearchCase-control studyOesophageal cancerGastric cancer case-control studySolid tumorsNon-cardia gastric cancerMajor global health problemUpper GI cancerSquamous cell oesophageal cancerUpper gastrointestinal malignanciesRisk of gastricUpper gastrointestinal carcinomasCancer case-control studyGastric Cancer StudyGastric adenocarcinoma patientsGlobal health problemGastrointestinal malignanciesAdenocarcinoma patientsColorectal cancerGastrointestinal carcinomasGI cancersGastric adenocarcinomaNovel genetic polymorphismsRisk factorsGastric cancerElevated risk
2009
IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas
Hoyo C, Schildkraut JM, Murphy SK, Chow W, Vaughan TL, Risch H, Marks JR, Jirtle RL, Calingeart B, Mayne S, Fraumeni J, Gammon MD. IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas. International Journal Of Cancer 2009, 125: 2673-2678. PMID: 19626700, PMCID: PMC3008656, DOI: 10.1002/ijc.24623.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsRisk of esophagealInsulin-like growth factor 2Gastric adenocarcinomaGastric cancerEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaNoncardia gastric cancerSquamous cell carcinomaExploratory subgroup analysisAnti-inflammatory drugsMannose-6-phosphate/insulin-like growth factor 2 receptorNoncardia adenocarcinomaGrowth factor 2Cigarette smokersCell carcinomaSubgroup analysisGrowth factor 2 receptorInsulin-like growth factor 2 receptorCardia adenocarcinomaFactor 2 receptorG alleleNonsynonymous genetic variantsAdenocarcinomaStudy participants
2008
Food group intake and risk of subtypes of esophageal and gastric cancer
Silvera S, Mayne ST, Risch H, Gammon MD, Vaughan TL, Chow W, Dubrow R, Schoenberg JB, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF. Food group intake and risk of subtypes of esophageal and gastric cancer. International Journal Of Cancer 2008, 123: 852-860. PMID: 18537156, PMCID: PMC3008621, DOI: 10.1002/ijc.23544.Peer-Reviewed Original ResearchConceptsGastric cardia adenocarcinomaNoncardia gastric adenocarcinomaHigh-fat dairyFood group intakesCardia adenocarcinomaGastric adenocarcinomaEsophageal adenocarcinomaGroup intakesOdds ratioGastric cancerHigh intakePopulation-based case-control studyNon-cardia gastric adenocarcinomaEsophageal squamous cell carcinomaRed meatTotal meat intakeSquamous cell carcinomaTotal vegetable intakeRisk of subtypesEsophageal adenocarcinoma riskCase-control studyGastric cardiaAdenocarcinoma riskCell carcinomaRisk factors
2007
Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas
Terry MB, Gammon MD, Zhang FF, Vaughan TL, Chow WH, Risch HA, Schoenberg JB, Mayne ST, Stanford JL, West AB, Rotterdam H, Blot WJ, Fraumeni JF, Santella RM. Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas. Cancer Causes & Control 2007, 18: 1039-1046. PMID: 17665311, DOI: 10.1007/s10552-007-9046-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAlcohol DehydrogenaseAlcohol DrinkingAllelesCase-Control StudiesChi-Square DistributionConfidence IntervalsEsophageal NeoplasmsFemaleGene FrequencyGenotypeHomozygoteHumansInterviews as TopicLogistic ModelsMaleMiddle AgedOdds RatioPolymorphism, GeneticRisk FactorsStomach NeoplasmsUnited StatesConceptsRisk of esophagealEsophageal adenocarcinomaHigh riskGastric Cancer StudyGastric cardia adenocarcinomaGastric adenocarcinomaCarcinoma riskConclusionThese dataCancer riskCardia adenocarcinomaTumor typesAdenocarcinomaAlcohol dehydrogenase 3Common polymorphismsEsophagealRisk estimatesCancer studiesRiskAlcohol dehydrogenase 3 geneDrinkersDehydrogenase 3PolymorphismNondrinkersMethodsWeGenotypesGST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas
Wideroff L, Vaughan TL, Farin FM, Gammon MD, Risch H, Stanford JL, Chow WH. GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas. Cancer Epidemiology 2007, 31: 233-236. PMID: 17646057, PMCID: PMC2268246, DOI: 10.1016/j.cdp.2007.03.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAllelesArylamine N-AcetyltransferaseCase-Control StudiesCytochrome P-450 CYP1A1Esophageal NeoplasmsFemaleGenetic Predisposition to DiseaseGlutathione S-Transferase piGlutathione TransferaseHumansIsoenzymesMaleMiddle AgedOdds RatioPolymerase Chain ReactionPolymorphism, GeneticRisk FactorsStomach NeoplasmsUnited StatesConceptsGastric adenocarcinomaOdds ratioGastric cardia adenocarcinomaEsophageal adenocarcinomaCardia adenocarcinomaElevated riskConfidence intervalsVal genotypePopulation-based case-control studyCYP1A1 Val/ValGSTP1 Val/Val genotypeNoncardia gastric adenocarcinomaEpidemiologic risk factorsRespective odds ratiosRisk of esophagealIle/Val genotypeVal/Val genotypeCase-control studyVal/ValN-acetyltransferase 1Same catchment areaHistologic subgroupsIncident casesRisk factorsGSTT1 genotype
2004
Nonsteroidal Anti-inflammatory Drug Use Associated with Reduced Incidence of Adenocarcinomas of the Esophagus and Gastric Cardia that Overexpress Cyclin D1A Population-Based Study
Gammon MD, Terry MB, Arber N, Chow WH, Risch HA, Vaughan TL, Schoenberg JB, Mayne ST, Stanford JL, Dubrow R, Rotterdam H, West AB, Fraumeni JF, Weinstein IB, Hibshoosh H. Nonsteroidal Anti-inflammatory Drug Use Associated with Reduced Incidence of Adenocarcinomas of the Esophagus and Gastric Cardia that Overexpress Cyclin D1A Population-Based Study. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 34-39. PMID: 14744730, DOI: 10.1158/1055-9965.epi-03-0198.Peer-Reviewed Original ResearchConceptsCyclin D1 statusOdds ratioCyclin D1NSAID useGastric cardiaRisk factorsCase groupD1 tumorsNonsteroidal anti-inflammatory drug usePopulation-based case-control studyAnti-inflammatory drug useMultivariate-adjusted odds ratioEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaUse of aspirinSquamous cell carcinomaGastric cancer patientsCase-control studyGastric cardia adenocarcinomaCigarette smokingCell carcinomaCancer patientsGastric adenocarcinomaEsophageal adenocarcinomaReduced incidence
2003
Population Attributable Risks of Esophageal and Gastric Cancers
Engel LS, Chow W, Vaughan TL, Gammon MD, Risch HA, Stanford JL, Schoenberg JB, Mayne ST, Dubrow R, Rotterdam H, West AB, Blaser M, Blot WJ, Gail MH, Fraumeni JF. Population Attributable Risks of Esophageal and Gastric Cancers. Journal Of The National Cancer Institute 2003, 95: 1404-1413. PMID: 13130116, DOI: 10.1093/jnci/djg047.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAlcohol DrinkingBody Mass IndexCarcinoma, Squamous CellCardiaCase-Control StudiesConfounding Factors, EpidemiologicEnzyme-Linked Immunosorbent AssayEsophageal NeoplasmsFeeding BehaviorFemaleFruitGastroesophageal RefluxHumansLife StyleMaleMiddle AgedNitritesObesityRisk AssessmentRisk FactorsSmokingStomach NeoplasmsStomach UlcerUnited StatesVegetablesConceptsCombined population attributable riskPopulation attributable riskNoncardia gastric adenocarcinomaEsophageal squamous cell carcinomaSquamous cell carcinomaGastric cardia adenocarcinomaBody mass indexGastric adenocarcinomaRisk factorsCell carcinomaCardia adenocarcinomaGastroesophageal refluxMass indexPylori infectionAttributable riskEsophageal adenocarcinomaGastric cancerVegetable consumptionMulticenter population-based case-control studyPopulation-based case-control studyPrevalence of smokingH. pylori infectionHelicobacter pylori infectionCase-control studyLow fruit
2001
Nutrient intake and risk of subtypes of esophageal and gastric cancer.
Mayne ST, Risch HA, Dubrow R, Chow WH, Gammon MD, Vaughan TL, Farrow DC, Schoenberg JB, Stanford JL, Ahsan H, West AB, Rotterdam H, Blot WJ, Fraumeni JF. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 1055-62. PMID: 11588131.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAge DistributionAgedCarcinoma, Squamous CellCase-Control StudiesConfidence IntervalsConnecticutDietEsophageal NeoplasmsFemaleHumansIncidenceMaleMiddle AgedNew JerseyOdds RatioPopulation SurveillanceReference ValuesRisk AssessmentRisk FactorsSex DistributionStomach NeoplasmsWashingtonConceptsNoncardia gastric cancerGastric cancerGastric cardiaNutrient intakeEsophageal adenocarcinomaOdds ratioHigh intakeTumor typesPopulation-based case-control studyVitamin C supplement useEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaRisk of adenocarcinomaSquamous cell carcinomaRisk of subtypesCase-control studyRisk of cancerPercentile of intakeSupplement useCell carcinomaDietary nitriteGastric adenocarcinomaRisk factorsDietary cholesterolIncidence rateFamily history of cancer and risk of esophageal and gastric cancers in the United States
Dhillon P, Farrow D, Vaughan T, Chow W, Risch H, Gammon M, Mayne S, Stanford J, Schoenberg J, Ahsan H, Dubrow R, West A, Rotterdam H, Blot W, Fraumeni J. Family history of cancer and risk of esophageal and gastric cancers in the United States. International Journal Of Cancer 2001, 93: 148-152. PMID: 11391635, DOI: 10.1002/ijc.1294.Peer-Reviewed Original ResearchConceptsNon-cardia gastric adenocarcinomaFamily historyGastric cancerEsophageal cancerGastric adenocarcinomaEsophageal adenocarcinomaEsophageal squamous cell cancerNon-cardia gastric cancerEsophageal squamous cell carcinomaSquamous cell cancerRisk of esophagealSquamous cell carcinomaCase-control studyGastric cardia adenocarcinomaHigh incidence areaGastric cardiaIncreased riskCell carcinomaDigestive cancersRisk factorsStomach cancerProstate cancerBreast cancerGastric tumorsCardia adenocarcinoma
2000
Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer
Farrow D, Vaughan T, Sweeney C, Gammon M, Chow W, Risch H, Stanford J, Hansten P, Mayne S, Schoenberg J, Rotterdam H, Ahsan H, West A, Dubrow R, Fraumeni J, Blot W. Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer. Cancer Causes & Control 2000, 11: 231-238. PMID: 10782657, DOI: 10.1023/a:1008913828105.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseNon-cardia gastric adenocarcinomaEsophageal adenocarcinomaGERD symptomsReflux diseaseH2 blockersGastric adenocarcinomaGastric cancerLarge population-based case-control studyPopulation-based case-control studyPopulation-based tumor registryEsophageal squamous cell carcinomaPerson structured interviewRisk of esophagealSquamous cell carcinomaEsophageal adenocarcinoma riskH2-receptor antagonistsCase-control studyGastric cardia adenocarcinomaRandom digit dialingLong-term usersTumor RegistryAdenocarcinoma riskDaily symptomsCell carcinoma
1998
Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia
Chow W, Blot W, Vaughan T, Risch H, Gammon M, Stanford J, Dubrow R, Schoenberg J, Mayne S, Farrow D, Ahsan H, West A, Rotterdam H, Niwa S, Fraumeni J. Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia. Journal Of The National Cancer Institute 1998, 90: 150-155. PMID: 9450576, DOI: 10.1093/jnci/90.2.150.Peer-Reviewed Original ResearchConceptsBody mass indexEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaSquamous cell carcinomaGastric cardia adenocarcinomaAdult body mass indexOdds ratioCell carcinomaGastric adenocarcinomaCardia adenocarcinomaGastric cardiaCase patientsMass indexEsophageal adenocarcinomaPopulation-based case-control studyAge groupsRisk of adenocarcinomaAdenocarcinoma of esophagusAnthropometric risk factorsPrevalence of obesityHealthy control subjectsCase-control studyYounger age groupsMagnitude of associationUnited States population
1997
Tobacco, Alcohol, and Socioeconomic Status and Adenocarcinomas of the Esophagus and Gastric Cardia
Gammon M, Ahsan H, Schoenberg J, West A, Rotterdam H, Niwa S, Blot W, Risch H, Dubrow R, Mayne S, Vaughan T, Stanford J, Farrow D, Chow W, Fraumeni J. Tobacco, Alcohol, and Socioeconomic Status and Adenocarcinomas of the Esophagus and Gastric Cardia. Journal Of The National Cancer Institute 1997, 89: 1277-1284. PMID: 9293918, DOI: 10.1093/jnci/89.17.1277.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaGastric cardiaSquamous cell carcinomaCell carcinomaGastric adenocarcinomaRisk factorsTumor typesNoncardia gastric adenocarcinomaDuration of smokingCurrent cigarette smokersRisk of esophagealMajor risk factorCase-control studyGastric cardia adenocarcinomaEarly-stage carcinogenesisCigarette smokersHigher ORsControl subjectsIncidence rateSimilar ORsCardia adenocarcinomaEstimates of riskAdenocarcinomaCardiaSmoking