1997
Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs
Moya F, Llanos A, Ríos A, Riquelme R, Moraga F, Rubio L, Salvo H, Jacobs H. Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs. Pediatric Research 1997, 42: 893-898. PMID: 9396575, DOI: 10.1203/00006450-199712000-00028.Peer-Reviewed Original ResearchConceptsLung functionPreterm lambsInitial doseIntratracheal administrationFC-100Administration of ExosurfSurfactant-deficient animalsSynthetic surfactant ExosurfArterial blood pressureDynamic lung compliancePreterm neonatesBlood pressureLung complianceSingle doseArterial PO2Arterial PCO2Surfactant deficiencyHeart rateAdditional doseExosurfStudy periodDoseAdministrationDosesSimilar changes
1989
Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment.
Gladstone I, Ehrenkranz R, Jacobs H. Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment. Pediatrics 1989, 84: 1072-6. PMID: 2587137, DOI: 10.1542/peds.84.6.1072.Peer-Reviewed Original ResearchMeSH KeywordsBronchopulmonary DysplasiaDexamethasoneFemaleHumansInfant, NewbornMaleRespiration, ArtificialRespiratory Function TestsWater-Electrolyte BalanceConceptsPulmonary function testsChronic lung diseaseFunction testsLung diseaseFluid balanceTotal pulmonary resistanceHours of treatmentFirst dosePulmonary resistanceUrine outputGestational ageRespiratory statusBirth weightExpiratory timeDexamethasone treatmentClinical teamDynamic complianceFluid shiftsInfantsDexamethasoneExtubationSignificant differencesTreatmentDiseaseHoursSurface tension and pulmonary compliance in premature rabbits
Mercurio M, Fiascone J, Lima D, Jacobs H. Surface tension and pulmonary compliance in premature rabbits. Journal Of Applied Physiology 1989, 66: 2039-2044. PMID: 2745272, DOI: 10.1152/jappl.1989.66.5.2039.Peer-Reviewed Original Research
1986
Left ventricular performance and contractility before and after volume infusion: a comparative study of preterm and full-term newborn lambs.
Baylen B, Ogata H, Ikegami M, Jacobs H, Jobe A, Emmanouilides G. Left ventricular performance and contractility before and after volume infusion: a comparative study of preterm and full-term newborn lambs. Circulation 1986, 73: 1042-1049. PMID: 3754496, DOI: 10.1161/01.cir.73.5.1042.Peer-Reviewed Original ResearchConceptsFull-term lambsLeft ventricular performanceVolume infusionPreterm lambsVentricular performanceStroke workLeft ventricular peak dP/dtLeft ventricleVentricular peak dP/dtLeft ventricular end-diastolic volumeFull-term newborn lambsVentricular end-diastolic volumeLeft ventricular stroke workPeak dP/dtGreater stroke workPostnatal circulatory adaptationSystemic vascular resistanceVentricular stroke workFull-term animalsDays gestational ageEnd-diastolic volumeLeft ventricular pressureDP/dtVascular resistancePulmonary functionHemodynamic Effects of High Frequency Ventilation in Surfactant-Treated Preterm Lambs
Oguchi K, Baylen B, Ikegami M, Jacobs H, Berry D, Jobe A, Emmanouilides G. Hemodynamic Effects of High Frequency Ventilation in Surfactant-Treated Preterm Lambs. Neonatology 1986, 49: 21-28. PMID: 3753885, DOI: 10.1159/000242505.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsBlood PressureHemodynamicsPremedicationPulmonary SurfactantsRespiration DisordersRespiration, ArtificialSheepConceptsHigh-frequency ventilationConventional ventilationHemodynamic effectsDuctus arteriosusPreterm lambsFrequency ventilationSame mean airway pressureLV end-diastolic volumeRight ductal shuntSurfactant-treated lambsMean airway pressureDeleterious hemodynamic effectsOrgan blood flowMin of ageEnd-diastolic volumeBlood gas valuesDays gestational ageLV stroke volumeBlood flow measurementsComparable ventilationDuctal shuntAirway pressureDuctal occlusionHemodynamic statusArterial pressure
1985
Leakage of protein in the immature rabbit lung; effect of surfactant replacement
Robertson B, Berry D, Curstedt T, Grossmann G, Machiko I, Jacobs H, Jobe A, Jones S. Leakage of protein in the immature rabbit lung; effect of surfactant replacement. Respiratory Physiology & Neurobiology 1985, 61: 265-276. PMID: 3840603, DOI: 10.1016/0034-5687(85)90070-2.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminsAnimalsAnimals, NewbornGestational AgeIodine RadioisotopesLungPhospholipidsProteinsPulmonary AlveoliPulmonary SurfactantsRabbitsRespiration, ArtificialConceptsSurfactant-treated animalsControl animalsSurfactant replacementAlveolar wash samplesOnset of ventilationAverage tidal volumeImmature rabbit lungsImmature newborn rabbitsInsufflation pressureImmature lungSurfactant inhibitorsTidal volumeRabbit lungsAlveolar compartmentNewborn rabbitsDay 27Wash samplesPrevious treatmentLeakage of proteinsDistribution of Pulmonary Blood Flow in Relation to Atelectasis in Premature Ventilated Lambs1–3
Berry D, Jobe A, Jacobs H, Ikegami M. Distribution of Pulmonary Blood Flow in Relation to Atelectasis in Premature Ventilated Lambs1–3. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 500-3. PMID: 4037523, DOI: 10.1164/arrd.1985.132.3.500.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornLungOrgan SizePulmonary AtelectasisPulmonary CirculationRespiration, ArtificialSheepConceptsBlood flowAtelectatic regionsLung volumePulmonary blood flow distributionAtelectatic lung segmentsLower lobe bronchusRespiratory distress syndromePulmonary blood flowPieces of lungBlood flow distributionBronchial obstructionDistress syndromeLobe bronchusBalloon occlusionAtelectatic lungLung segmentsBalloon catheterPulmonary bloodAtelectasisLungBloodLambsPretermBronchusCatheterLung protein leaks in ventilated lambs: effects of gestational age
Jobe A, Jacobs H, Ikegami M, Berry D. Lung protein leaks in ventilated lambs: effects of gestational age. Journal Of Applied Physiology 1985, 58: 1246-1251. PMID: 3988678, DOI: 10.1152/jappl.1985.58.4.1246.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminsAnimalsAnimals, NewbornGestational AgeLungPhosphatidylcholinesProteinsPulmonary AlveoliRespiration, ArtificialSheepTherapeutic IrrigationTissue DistributionConceptsDays gestational ageGestational ageFull-term lambsGroups of lambsVentilated lambsLung tissueAlveolar washBlood gas valuesNatural sheep surfactantPremature lambsPreterm lambsPremature lungIntravascular injectionSheep surfactantLung proteinGas valuesPCO2 valuesAgeAlveoliAirwayLambsBidirectional fluxesTissueGroupAlbuminAccumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs
Jacobs H, Jobe A, Ikegami M, Jones S. Accumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs. Experimental Lung Research 1985, 8: 125-140. PMID: 3839748, DOI: 10.3109/01902148509057517.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlood Gas AnalysisHydrogen-Ion ConcentrationIsotope LabelingPulmonary AlveoliPulmonary SurfactantsRespiration, ArtificialSheepConceptsAlveolar washTreatment doseAlveolar surfactantMean gestational ageArterial blood gasPeak inspiratory pressureMin of ageSurfactant pool sizeAlveolar surfactant accumulationPhosphatidylcholine specific activityCesarean sectionPremature lambsGestational agePremature lungInspiratory pressureIntratracheal administrationBlood gasTrace doseDilution techniqueDoseAgeAirwayPool sizeBirthAccumulation of surfactant
1984
Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant.
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant and pulmonary blood flow distributions following treatment of premature lambs with natural surfactant. Journal Of Clinical Investigation 1984, 73: 848-856. PMID: 6546766, PMCID: PMC425089, DOI: 10.1172/jci111280.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornGestational AgeLungMicrospheresPulmonary CirculationPulmonary SurfactantsRespiration, ArtificialSheepTissue DistributionConceptsPieces of lungBlood flow distributionPulmonary blood flow distributionLungs of lambsMechanical ventilationRight ductal shuntPulmonary blood flowConstant distending pressurePeriod of ventilationGroups of lambsDuctal shuntPremature lambsAtelectatic areasSurfactant instillationVentricular outputTracheal instillationDistending pressureBlood flowLungLung piecesVentilationInstillationBirthLambsNatural surfactant