1989
Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits
Gladstone I, Mercurio M, Devenny S, Jacobs H. Antenatal steroids, postnatal surfactant, and pulmonary function in premature rabbits. Journal Of Applied Physiology 1989, 67: 1377-1382. PMID: 2793738, DOI: 10.1152/jappl.1989.67.4.1377.Peer-Reviewed Original ResearchConceptsDynamic compliancePulmonary functionLung resistanceTotal lung conductanceTotal lung resistancePulmonary function testsRespiratory distress syndromeConsistent tidal volumeAntenatal corticosteroidsAntenatal steroidsIntramuscular betamethasonePostnatal surfactantDistress syndromeFunction testsCombination therapyPulmonary mechanicsExpiratory timePremature rabbitsTidal volumeStatic complianceLung conductanceFirst breathDay 27Day 25Steroids
1985
Effects of high-frequency and conventional ventilation on the premature lamb lung
Solimano A, Bryan C, Jobe A, Ikegami M, Jacobs H. Effects of high-frequency and conventional ventilation on the premature lamb lung. Journal Of Applied Physiology 1985, 59: 1571-1577. PMID: 3840801, DOI: 10.1152/jappl.1985.59.5.1571.Peer-Reviewed Original ResearchConceptsMean airway pressureConventional mechanical ventilationProtein leakPremature lamb lungsFetal lung fluidRespiratory distress syndromeDays gestational ageDegree of leakHigh-frequency oscillationsGroups of lambsAirway pressureCesarean sectionDistress syndromeGestational ageConventional ventilationMechanical ventilationPathological findingsLung diseaseBlood gasesImmature lungVentilator settingsEpithelial necrosisBlood gasLung sectionsTracer doseDistribution of Pulmonary Blood Flow in Relation to Atelectasis in Premature Ventilated Lambs1–3
Berry D, Jobe A, Jacobs H, Ikegami M. Distribution of Pulmonary Blood Flow in Relation to Atelectasis in Premature Ventilated Lambs1–3. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 500-3. PMID: 4037523, DOI: 10.1164/arrd.1985.132.3.500.Peer-Reviewed Original ResearchConceptsBlood flowAtelectatic regionsLung volumePulmonary blood flow distributionAtelectatic lung segmentsLower lobe bronchusRespiratory distress syndromePulmonary blood flowPieces of lungBlood flow distributionBronchial obstructionDistress syndromeLobe bronchusBalloon occlusionAtelectatic lungLung segmentsBalloon catheterPulmonary bloodAtelectasisLungBloodLambsPretermBronchusCatheter
1983
Surfactant Pool Sizes and Severity of Respiratory Distress Syndrome in Prematurely Delivered Lambs1–3
Jobe A, Ikegami M, Jacobs H, Jones S. Surfactant Pool Sizes and Severity of Respiratory Distress Syndrome in Prematurely Delivered Lambs1–3. American Journal Of Respiratory And Critical Care Medicine 1983, 127: 751-5. PMID: 6552894, DOI: 10.1164/arrd.1983.127.6.751.Peer-Reviewed Original ResearchConceptsLung diseaseAlveolar washCompliant lungsMinimal surface tensionLow minimal surface tensionRespiratory distress syndromePeak inspiratory pressurePhosphatidylcholine pool sizesDays gestational ageSurfactant pool sizePremature lambsDistress syndromeGestational ageInspiratory pressureLung tissueRespiratory diseaseTidal volumeLung slicesSurfactant phosphatidylcholineTotal phosphatidylcholineDiseaseSeverityPool sizeRate of incorporationLungSurfactant function in respiratory distress syndrome
Ikegami M, Jacobs H, Jobe A. Surfactant function in respiratory distress syndrome. The Journal Of Pediatrics 1983, 102: 443-447. PMID: 6687477, DOI: 10.1016/s0022-3476(83)80673-8.Peer-Reviewed Original ResearchConceptsRespiratory distress syndromeDistress syndromeAirway samplesDay of extubationAirways of infantsSurface tension-lowering propertiesNatural sheep surfactantSupernatant fractionHigher minimum surface tensionsMinimum surface tensionRespiratory failureTracheal intubationSheep surfactantSyndromeInfantsSurfactant functionExtubationIntubation
1982
Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates
Jacobs H, Jobe A, Ikegami M, Glatz T, Jones S, Barajas L. Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates. Pediatric Research 1982, 16: 424-429. PMID: 6920645, DOI: 10.1203/00006450-198206000-00005.Peer-Reviewed Original ResearchConceptsRespiratory failureDistal airwaysRespiratory distress syndromeMin of ageDays gestational agePressure-volume curvesClinical deteriorationClinical responsePremature lambsDistress syndromePosttreatment groupGestational ageMechanical ventilationProgressive dilatationUntreated lungsPremature babiesTracheal instillationBlood gasAlveolar washSurfactant replacementBody weightLung structureAirwayMinimum surface tensionHistologic measurements