1990
Effect of artificial surfactant on pulmonary function in preterm and full-term lambs
Gladstone I, Ray A, Salafia C, Perez-Fontan J, Mercurio M, Jacobs H. Effect of artificial surfactant on pulmonary function in preterm and full-term lambs. Journal Of Applied Physiology 1990, 69: 465-472. PMID: 2121700, DOI: 10.1152/jappl.1990.69.2.465.Peer-Reviewed Original ResearchConceptsFunctional residual capacityFull-term lambsMean lung volumePreterm lambsLung volumeResidual capacityTest agentsFC-100Higher minimum surface tensionsRespiratory failureLung functionPulmonary functionLung expansionAlveolar washMinimum surface tensionDynamic complianceArtificial surfactantQualitative histologyOxygenationLambsAgentsGas exchangePretermComplianceHistology
1984
A protein from airways of premature lambs that inhibits surfactant function
Ikegami M, Jobe A, Jacobs H, Lam R. A protein from airways of premature lambs that inhibits surfactant function. Journal Of Applied Physiology 1984, 57: 1134-1142. PMID: 6209255, DOI: 10.1152/jappl.1984.57.4.1134.Peer-Reviewed Original Research
1983
Surfactant function in respiratory distress syndrome
Ikegami M, Jacobs H, Jobe A. Surfactant function in respiratory distress syndrome. The Journal Of Pediatrics 1983, 102: 443-447. PMID: 6687477, DOI: 10.1016/s0022-3476(83)80673-8.Peer-Reviewed Original ResearchConceptsRespiratory distress syndromeDistress syndromeAirway samplesDay of extubationAirways of infantsSurface tension-lowering propertiesNatural sheep surfactantSupernatant fractionHigher minimum surface tensionsMinimum surface tensionRespiratory failureTracheal intubationSheep surfactantSyndromeInfantsSurfactant functionExtubationIntubation
1982
Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates
Jacobs H, Jobe A, Ikegami M, Glatz T, Jones S, Barajas L. Premature Lambs Rescued from Respiratory Failure with Natural Surfactant: Clinical and Biophysical Correlates. Pediatric Research 1982, 16: 424-429. PMID: 6920645, DOI: 10.1203/00006450-198206000-00005.Peer-Reviewed Original ResearchConceptsRespiratory failureDistal airwaysRespiratory distress syndromeMin of ageDays gestational agePressure-volume curvesClinical deteriorationClinical responsePremature lambsDistress syndromePosttreatment groupGestational ageMechanical ventilationProgressive dilatationUntreated lungsPremature babiesTracheal instillationBlood gasAlveolar washSurfactant replacementBody weightLung structureAirwayMinimum surface tensionHistologic measurements
1981
Sequential treatments of premature lambs with an artificial surfactant and natural surfactant.
Ikegami M, Jobe A, Jacobs H, Jones S. Sequential treatments of premature lambs with an artificial surfactant and natural surfactant. Journal Of Clinical Investigation 1981, 68: 491-496. PMID: 6790576, PMCID: PMC370823, DOI: 10.1172/jci110280.Peer-Reviewed Original ResearchConceptsArtificial surfactantPremature lambsGestational age lambsFetal lung fluidPO2 valuesGroups of lambsPressure-volume characteristicsMinimum surface tensionPremature lungAirway samplesNatural surfactant lipidAge lambsUntreated lambsMean pO2 valuesMinimal surface tensionLung fluidSurfactant lipidsSequential treatmentTreatmentNatural surfactantLambsHgPCO2 valuesAirwayLung