1997
Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs
Moya F, Llanos A, Ríos A, Riquelme R, Moraga F, Rubio L, Salvo H, Jacobs H. Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs. Pediatric Research 1997, 42: 893-898. PMID: 9396575, DOI: 10.1203/00006450-199712000-00028.Peer-Reviewed Original ResearchConceptsLung functionPreterm lambsInitial doseIntratracheal administrationFC-100Administration of ExosurfSurfactant-deficient animalsSynthetic surfactant ExosurfArterial blood pressureDynamic lung compliancePreterm neonatesBlood pressureLung complianceSingle doseArterial PO2Arterial PCO2Surfactant deficiencyHeart rateAdditional doseExosurfStudy periodDoseAdministrationDosesSimilar changes
1985
Accumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs
Jacobs H, Jobe A, Ikegami M, Jones S. Accumulation of Alveolar Surfactant Following Delivery and Ventilation of Premature Lambs. Experimental Lung Research 1985, 8: 125-140. PMID: 3839748, DOI: 10.3109/01902148509057517.Peer-Reviewed Original ResearchConceptsAlveolar washTreatment doseAlveolar surfactantMean gestational ageArterial blood gasPeak inspiratory pressureMin of ageSurfactant pool sizeAlveolar surfactant accumulationPhosphatidylcholine specific activityCesarean sectionPremature lambsGestational agePremature lungInspiratory pressureIntratracheal administrationBlood gasTrace doseDilution techniqueDoseAgeAirwayPool sizeBirthAccumulation of surfactantClearance of Large Amounts of Natural Surfactants and Liposomes of Dipalmitoylphosphatidylcholine from the Lungs of Rabbits
Oguchi K, Ikegami M, Jacobs H, Jobe A. Clearance of Large Amounts of Natural Surfactants and Liposomes of Dipalmitoylphosphatidylcholine from the Lungs of Rabbits. Experimental Lung Research 1985, 9: 221-235. PMID: 3841050, DOI: 10.3109/01902148509057525.Peer-Reviewed Original ResearchConceptsTotal lungLung tissueRabbit surfactantAlveolar washSheep surfactantAlveolar surfactant pool sizeEndogenous surfactant metabolismEndogenous surfactant poolsSurfactant pool sizeDifferent surfactant preparationsNatural rabbit surfactantLungs of rabbitsNatural sheep surfactantIntratracheal administrationIntratracheal injectionLung phosphatidylcholineSurfactant poolQuantity of phosphatidylcholineSurfactant metabolismLungClearance rateSurfactant phosphatidylcholineTotal phosphatidylcholineMetabolic responseSurfactant preparations