2013
Studies of NVP-BEZ235 in melanoma.
Sznol JA, Jilaveanu LB, Kluger HM. Studies of NVP-BEZ235 in melanoma. Current Cancer Drug Targets 2013, 13: 165-74. PMID: 23215722, DOI: 10.2174/1568009611313020006.Peer-Reviewed Original ResearchConceptsNVP-BEZ235Dual PI3K/mTOR inhibitorNovel dual PI3K/mTOR inhibitorPI3K/mTOR inhibitorSpecific molecular inhibitorsPotential escape mechanismsMTOR inhibitorsPI3K-pathwayEscape mechanismsMulti-level targetingMalignant melanocytesMolecular inhibitorsDrug developmentMelanomaAttractive targetInhibitorsPathwayNumerous studies
2012
Chapter One Vertical Pathway Targeting in Cancer Therapy
Shahbazian D, Sznol J, Kluger HM. Chapter One Vertical Pathway Targeting in Cancer Therapy. Advances In Pharmacology 2012, 65: 1-26. PMID: 22959021, DOI: 10.1016/b978-0-12-397927-8.00001-4.Peer-Reviewed Original ResearchConceptsVital cellular processesDifferent signaling pathwaysDNA maintenanceCellular processesCell divisionDrug combinationsSignaling pathwaysSame pathwayAdaptive responseParticular mutationCell proliferationRecent discoveryPathwayTypes of cancerFragile nodesAdditional targetsGrowth inhibitoryUnavoidable toxicitiesMutationsMultitarget inhibitionCytotoxic effectsCancer researchSolid tumorsProlonged responseMalignant cells
2008
Apoptosis: a clinical perspective
Borden EC, Kluger H, Crowley J. Apoptosis: a clinical perspective. Nature Reviews Drug Discovery 2008, 7: 959-959. PMID: 19065702, DOI: 10.1038/nrd2756.Peer-Reviewed Original Research
2006
Association between pathways in regulatory networks
Kluger Y, Kluger H, Tuck D. Association between pathways in regulatory networks. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2006, 2006: 2036-2040. PMID: 17946929, DOI: 10.1109/iembs.2006.260730.Peer-Reviewed Original ResearchConceptsRegulatory networksCo-regulated pathwaysHuman regulatory networkRegulatory network connectivityDistinct cell typesTranscriptional regulatory levelCondition-specific networksGene regulationIndividual genesCell statesTranscriptional activityCell typesCell progressionExpression signaturesNumerous pathwaysGene profilesRemarkable connectivityMultiple pathwaysPathwayGenesRegulatory levelsRegulationExpressionCellsNotable differences