2016
Melanoma Brain Metastasis Pseudoprogression after Pembrolizumab Treatment
Cohen JV, Alomari AK, Vortmeyer AO, Jilaveanu LB, Goldberg SB, Mahajan A, Chiang VL, Kluger HM. Melanoma Brain Metastasis Pseudoprogression after Pembrolizumab Treatment. Cancer Immunology Research 2016, 4: 179-182. PMID: 26701266, PMCID: PMC4881844, DOI: 10.1158/2326-6066.cir-15-0160.Peer-Reviewed Original ResearchConceptsCentral nervous systemBrain metastasesActive brain lesionsNew immunomodulating agentsImmune checkpoint inhibitorsRole of immunotherapyPembrolizumab treatmentCheckpoint inhibitorsCNS lesionsReactive astrocytosisImmune suppressionPerilesional edemaInflammatory cellsMicroglial cellsImmunomodulating agentMental statusBrain lesionsHistologic evaluationMost trialsNervous systemCentral enhancementTumor cellsPatientsMetastasisLesions
2015
Melanoma: Clinical Presentations
Kibbi N, Kluger H, Choi JN. Melanoma: Clinical Presentations. Cancer Treatment And Research 2015, 167: 107-129. PMID: 26601860, DOI: 10.1007/978-3-319-22539-5_4.Peer-Reviewed Original ResearchConceptsNon-cutaneous lesionsUpper gastrointestinal mucosaMalignant skin lesionsGenital mucosaUveal tractClinical presentationDistant metastasisCutaneous lesionsPattern of spreadTypical presentationGastrointestinal mucosaSkin lesionsOral cavityMucosal surfacesMalignant cellsMelanomaRed lesionsLesionsRegional spreadBasal layerMucosaMelanocytesPresentationLeptomeningesMetastasis
2014
Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008
Lott JP, Wititsuwannakul J, Lee JJ, Ariyan S, Narayan D, Kluger HH, Lazova R. Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008. Journal Of The American Academy Of Dermatology 2014, 71: 1077-1082. PMID: 25308882, PMCID: PMC6133655, DOI: 10.1016/j.jaad.2014.08.026.Peer-Reviewed Original ResearchConceptsMalignant melanomaSpitzoid malignant melanomasSpitz neviClinical characteristicsRetrospective cohort studyMultivariate logistic regressionMalignant melanoma diagnosisSelect patientsCohort studyYounger patientsClinical featuresSingle institutionMale genderMelanomaSmall lesionsLogistic regressionNeviSmall sample sizeLesionsMelanoma diagnosisDiagnosisUnmeasured confoundingPatientsDescriptive statisticsAge
2013
Advances in therapy for melanoma brain metastases
Flanigan JC, Jilaveanu LB, Chiang VL, Kluger HM. Advances in therapy for melanoma brain metastases. Clinics In Dermatology 2013, 31: 264-281. PMID: 23608446, DOI: 10.1016/j.clindermatol.2012.08.008.Peer-Reviewed Original Research