2010
A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug Susceptibilities
Mirza H, Teo JD, Upcroft J, Tan KS. A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug Susceptibilities. Antimicrobial Agents And Chemotherapy 2010, 55: 637-648. PMID: 21098237, PMCID: PMC3028762, DOI: 10.1128/aac.00900-10.Peer-Reviewed Original ResearchConceptsTreatment failureBlastocystis infectionBlastocystis sppNew treatment optionsDrug-resistant isolatesStandard therapyTreatment regimensTreatment optionsMetronidazole resistanceControversial pathogenesisSubtype 4Drug susceptibilityImportant subtypeDrug sensitivitySubtypesStandard antimicrobialsInfectionZoonotic subtypesViability assaysPresent studyParasitesFirst studyCotrimoxazoleRegimensFailure
2008
Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity
Mirza H, Tan KS. Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity. Parasitology Research 2008, 104: 355-361. PMID: 18846388, DOI: 10.1007/s00436-008-1203-1.Peer-Reviewed Original ResearchConceptsCysteine protease activityIntra-subtype variationRodent isolatesIL-8 responseColonic epithelial cellsHuman secretory IgAClinical studiesSecretory IgAAnimal modelsNon-virulent strainsProtease activityBlastocystis subtypesCysteine proteasesEpithelial cellsGiardia intestinalisCellular mechanismsZoonotic potentialBlastocystisEntamoeba histolyticaAvian isolatesPresent studyIsolatesSame isolatesParasitesIgA