2016
Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation
Kundishora AJ, Gummadavelli A, Ma C, Liu M, McCafferty C, Schiff ND, Willie JT, Gross RE, Gerrard J, Blumenfeld H. Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Cerebral Cortex 2016, 27: 1964-1975. PMID: 26941379, PMCID: PMC5964488, DOI: 10.1093/cercor/bhw035.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep brain stimulationLimbic seizuresBrain stimulationImpaired consciousnessNetwork inhibition hypothesisRisk of mortalityNovel therapeutic approachesDual-site stimulationCentral lateral nucleusDisorders of consciousnessQuality of lifeFocal limbicSurgical therapyRefractory epilepsyFocal seizuresNucleus oralisBilateral stimulationIntralaminar thalamusRat modelTherapeutic approachesLateral nucleusBehavioral arousalConscious arousalResponsive neurostimulation
2011
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingBrain WavesCerebral CortexCerebrovascular CirculationCorpus StriatumDisease Models, AnimalElectroencephalographyElectrophysiologyEpilepsyImage Processing, Computer-AssistedLaser-Doppler FlowmetryMagnetic Resonance ImagingNicotinic AntagonistsOxygenRatsRats, WistarThalamusTubocurarineVibrissaeConceptsCerebral blood flowCerebral blood volumeLocal field potentialsNeuronal activityLaser Doppler cerebral blood flowSubcortical structuresWAG/Rij ratsNeuronal activity decreasesHuman absence epilepsySpike-wave dischargesWAG/RijMultiunit activity recordingsFMRI signalsFunctional magnetic resonance imaging (fMRI) signalsMagnetic resonance imaging signalsFMRI decreasesCBF decreaseHemodynamic changesCerebral cortexBasal gangliaSomatosensory cortexAbsence epilepsyWhisker stimulationBlood flowAnimal models