2020
Accuracy of a novel noninvasive secretin-enhanced MRCP severity index scoring system for diagnosis of chronic pancreatitis: correlation with EUS-based Rosemont criteria
Souza D, Alessandrino F, Ketwaroo G, Sawhney M, Mortele K. Accuracy of a novel noninvasive secretin-enhanced MRCP severity index scoring system for diagnosis of chronic pancreatitis: correlation with EUS-based Rosemont criteria. La Radiologia Medica 2020, 125: 816-826. PMID: 32266691, DOI: 10.1007/s11547-020-01181-3.Peer-Reviewed Original Research
2019
Dietary quality and the colonic mucosa–associated gut microbiome in humans
Liu Y, Ajami N, El-Serag H, Hair C, Graham D, White D, Chen L, Wang Z, Plew S, Kramer J, Cole R, Hernaez R, Hou J, Husain N, Jarbrink-Sehgal M, Kanwal F, Ketwaroo G, Natarajan Y, Shah R, Velez M, Mallepally N, Petrosino J, Jiao L. Dietary quality and the colonic mucosa–associated gut microbiome in humans. American Journal Of Clinical Nutrition 2019, 110: 701-712. PMID: 31291462, PMCID: PMC6736447, DOI: 10.1093/ajcn/nqz139.Peer-Reviewed Original ResearchConceptsTotal HEIColonic mucosaHigher BacteroidesDietary qualityGut microbiomeCross-sectional observational studyLower scoresColonic mucosal biopsiesHealthy Eating IndexDifferent colon segmentsMucosal biopsiesMultivariable analysisObservational studyColon segmentsDietary consumptionHealthy individualsMultivariate analysisFree participantsMucosaNormal individualsFusobacteriumWhole grainsTaxonomic relative abundancesScoresSoy beverageDietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon
Gurwara S, Ajami N, Jang A, Hessel F, Chen L, Plew S, Wang Z, Graham D, Hair C, White D, Kramer J, Kourkoumpetis T, Hoffman K, Cole R, Hou J, Husain N, Jarbrink-Sehgal M, Hernaez R, Kanwal F, Ketwaroo G, Shah R, Velez M, Natarajan Y, El-Serag H, Petrosino J, Jiao L. Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon. Nutrients 2019, 11: 613. PMID: 30871224, PMCID: PMC6470629, DOI: 10.3390/nu11030613.Peer-Reviewed Original ResearchConceptsB vitaminsDietary consumptionGut microbiotaMucosa-associated gut microbiotaConsumption of folateFood frequency questionnaireHigh consumptionFrequency questionnaireColonic biopsiesNormal colonGut microbiomeColonic bacteriaOne-carbon metabolismDaily consumptionOperational taxonomic unit classificationStatistical significanceDietary nutrientsTaxonomic relative abundancesVitaminFolateMicrobiota
2017
Mechanical colon cleansing for screening colonoscopy: A randomized controlled trial
Ayub K, Ketwaroo G, Abudayyeh S, Ibrahim A, Cole R, Brumfield‐Brown R, Qureshi W, Rabeneck L, Graham D. Mechanical colon cleansing for screening colonoscopy: A randomized controlled trial. Journal Of Digestive Diseases 2017, 18: 691-697. PMID: 29160622, DOI: 10.1111/1751-2980.12562.Peer-Reviewed Original ResearchThe Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing
Kothari D, Ketwaroo G, Freedman S, Sheth S. The Impact of Risk Factors of Chronic Pancreatitis on Secretin Pancreatic Function Testing. Pancreas 2017, 46: 887-890. PMID: 28697128, DOI: 10.1097/mpa.0000000000000871.Peer-Reviewed Original ResearchConceptsRecurrent acute pancreatitisPeak bicarbonate concentrationHistory of APAcute pancreatitisRisk factorsPancreatic function testingChronic pancreatitisLocal complicationsFunction testingFemale sexBicarbonate concentrationRetrospective reviewUnivariate analysisFamily historyTobacco usePancreatitisPatientsMultivariate analysisAlcohol useComplicationsSignificant differencesSexFactorsHistoryComparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis
Kothari D, Ketwaroo G, Sawhney M, Freedman S, Sheth S. Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis. Pancreas 2017, 46: 770-775. PMID: 28609365, DOI: 10.1097/mpa.0000000000000829.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersCross-Over StudiesEndoscopes, GastrointestinalEndoscopy, GastrointestinalEndosonographyFeasibility StudiesFemaleHumansMaleMiddle AgedPancreatic Function TestsPancreatic JuicePancreatitis, ChronicPredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsSecretinTime FactorsWorkflowConceptsChronic pancreatitisPeak bicarbonate concentrationPancreatic function testsEndoscopic ultrasonographyFunction testsPoor concordanceProspective crossover studyPancreatic function testingFunctional testsBicarbonate concentrationPeak bicarbonateSecretin testingCrossover studyFunction testingTest concordanceDiscordant findingsFunctional assessmentPatientsImproved concordancePancreatitisSignificant correlationUltrasonographyConcordanceFeasible testCutoff
2016
Risk Profiles for Barrett’s Esophagus Differ between New and Prevalent, and Long- and Short-Segment Cases
Tan M, Murrey-Ittmann J, Nguyen T, Ketwaroo G, El-Serag H, Thrift A. Risk Profiles for Barrett’s Esophagus Differ between New and Prevalent, and Long- and Short-Segment Cases. PLOS ONE 2016, 11: e0169250. PMID: 28036381, PMCID: PMC5201279, DOI: 10.1371/journal.pone.0169250.Peer-Reviewed Original ResearchConceptsSpecialized intestinal metaplasiaShort-segment BELong-segment BEPrimary care controlsH. pylori infectionRisk factorsGERD symptomsElective esophagogastroduodenoscopyEndoscopy controlsCare controlPylori infectionCase definitionBE casesControl groupGastroesophageal reflux disease symptomsMultivariate logistic regression modelFrequent GERD symptomsPrimary care clinicsCross-sectional studyVeterans Affairs centersLogistic regression modelsEligible patientsH2RA useMedication useCare clinicsThe Use of Standard Gastrointestinal Endoscopic Ultrasound to Assess Cardiac Anatomy
Sentissi K, Sawhney M, Pleskow D, Sepe P, Mella J, Kwittken B, Ketwaroo G, Subramaniam B. The Use of Standard Gastrointestinal Endoscopic Ultrasound to Assess Cardiac Anatomy. Anesthesia & Analgesia 2016, 123: 547-550. PMID: 27541718, DOI: 10.1213/ane.0000000000001380.Peer-Reviewed Original ResearchConceptsVentricular functionAortic valveMitral valveRight ventricular systolic functionLinear echoendoscopeCardiovascular Anesthesiologists guidelinesEchocardiography/SocietyDepressed ventricular functionProspective observational studyVentricular systolic functionTransesophageal echocardiography examinationStandard clinical indicationsAcademic medical centerEarly diagnostic toolFormal echocardiographyPericardial effusionSystolic functionAortic dissectionAortic stenosisPulmonic valveTricuspid valveEchocardiography examinationAtrial appendageCardiac assessmentClinical indicationsLocalizing Acute Lower Gastrointestinal Hemorrhage: CT Angiography Versus Tagged RBC Scintigraphy.
Feuerstein J, Ketwaroo G, Tewani S, Cheesman A, Trivella J, Raptopoulos V, Leffler D. Localizing Acute Lower Gastrointestinal Hemorrhage: CT Angiography Versus Tagged RBC Scintigraphy. American Journal Of Roentgenology 2016, 207: 578-84. PMID: 27303989, DOI: 10.2214/ajr.15.15714.Peer-Reviewed Original ResearchConceptsAcute lower gastrointestinal bleedingLower gastrointestinal bleedingLower gastrointestinal hemorrhageCT angiographyRBC scintigraphyScintigraphic scansGastrointestinal bleedingGastrointestinal hemorrhageActive lower gastrointestinal bleedingAcute lower gastrointestinal hemorrhageUtility of CTAAcute kidney injuryBlood transfusion requirementsTertiary care hospitalAverage hospital lengthSite of bleedingActive gastrointestinal bleedingActive bleedingHospital lengthHospital mortalityKidney injuryTransfusion requirementsCare hospitalRetrospective reviewScintigraphic examination
2015
High Glasgow Blatchford Score at admission is associated with recurrent bleeding after discharge for patients hospitalized with upper gastrointestinal bleeding
Sengupta N, Tapper E, Patwardhan V, Ketwaroo G, Thaker A, Leffler D, Feuerstein J. High Glasgow Blatchford Score at admission is associated with recurrent bleeding after discharge for patients hospitalized with upper gastrointestinal bleeding. Endoscopy 2015, 48: 9-15. PMID: 26340604, DOI: 10.1055/s-0034-1392651.Peer-Reviewed Original ResearchConceptsGlasgow-Blatchford scoreUpper gastrointestinal bleedingGBS scoresBlatchford scoreGastrointestinal bleedingMultivariable analysisEndoscopic interventionHigh riskIntensive care unit admissionCare unit admissionMultivariable Cox regressionPost-discharge outcomesGBS patientsUnit admissionCause readmissionHospital deathRecurrent bleedingCohort studyReadmission ratesConsecutive patientsHospital readmissionSignificant morbidityCox regressionPatientsReadmissionRisk Factors for Adverse Outcomes in Patients Hospitalized With Lower Gastrointestinal Bleeding
Sengupta N, Tapper E, Patwardhan V, Ketwaroo G, Thaker A, Leffler D, Feuerstein J. Risk Factors for Adverse Outcomes in Patients Hospitalized With Lower Gastrointestinal Bleeding. Mayo Clinic Proceedings 2015, 90: 1021-1029. PMID: 26141075, PMCID: PMC4770256, DOI: 10.1016/j.mayocp.2015.04.024.Peer-Reviewed Original ResearchConceptsRecurrent lower gastrointestinal bleedingLower gastrointestinal bleedingCharlson Comorbidity Index scoreComorbidity Index scoreActive malignancyRisk factorsGastrointestinal bleedingAdverse outcomesMultivariable Cox proportional hazards regression modelsHigher Charlson Comorbidity Index scoresIndex scoreCox proportional hazards regression modelProportional hazards regression modelsBeth Israel Deaconess Medical CenterProspective observational studyHazards regression modelsAssociation of variablesRecurrent bleedingHospital dischargeConsecutive patientsHospital readmissionObservational studyMedical CenterMortality riskPatientsSalvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective
Sengupta N, Ketwaroo G, Bak D, Kedar V, Chuttani R, Berzin T, Sawhney M, Pleskow D. Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective. Gastrointestinal Endoscopy 2015, 82: 443-448. PMID: 25887715, DOI: 10.1016/j.gie.2015.01.033.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaLow-grade dysplasiaRadiofrequency ablationIntramucosal carcinomaRecurrent dysplasiaEndoscopic therapyIntestinal metaplasiaBE dysplasiaEffective endoscopic therapyEradication of dysplasiaSafety of cryotherapyTertiary care centerBarrett's esophagus dysplasiaRFA sessionsSalvage cryotherapyCohort studySecondary outcomesHiatal herniaSingle centerInitial eradicationRetrospective natureEffective treatmentPatientsCryotherapyDysplasia
2014
The Risks of Thromboembolism Vs. Recurrent Gastrointestinal Bleeding after Interruption of Systemic Anticoagulation in Hospitalized Inpatients With Gastrointestinal Bleeding: A Prospective Study
Sengupta N, Feuerstein J, Patwardhan V, Tapper E, Ketwaroo G, Thaker A, Leffler D. The Risks of Thromboembolism Vs. Recurrent Gastrointestinal Bleeding after Interruption of Systemic Anticoagulation in Hospitalized Inpatients With Gastrointestinal Bleeding: A Prospective Study. The American Journal Of Gastroenterology 2014, 110: 328. PMID: 25512338, DOI: 10.1038/ajg.2014.398.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsBenzimidazolesBeta-AlanineCohort StudiesDabigatranEnoxaparinFemaleGastrointestinal HemorrhageHeparinHumansIschemic Attack, TransientLongitudinal StudiesMaleMiddle AgedMorpholinesPatient ReadmissionProspective StudiesPulmonary EmbolismPyrazolesPyridonesRecurrenceRivaroxabanStrokeThiophenesThromboembolismVenous ThrombosisWarfarinWithholding TreatmentConceptsRecurrent gastrointestinal bleedingGastrointestinal bleedingSystemic anticoagulationAnticoagulation continuationThromboembolic eventsThrombotic eventsEtiology of GIBProspective observational cohort studyIntensive care unit careHospital transfusion requirementsMajor thrombotic episodesRisk of continuationObservational cohort studyRisk of thromboembolismCox proportional hazardsTransfusion requirementsCohort studyHospital dischargeUnit careConsecutive patientsHospital readmissionThrombotic episodesProspective studyHospitalized inpatientsFollowing outcomes
2013
Defining the Accuracy of Secretin Pancreatic Function Testing in Patients With Suspected Early Chronic Pancreatitis
Ketwaroo G, Brown A, Young B, Kheraj R, Sawhney M, Mortele K, Najarian R, Tewani S, Dasilva D, Freedman S, Sheth S. Defining the Accuracy of Secretin Pancreatic Function Testing in Patients With Suspected Early Chronic Pancreatitis. The American Journal Of Gastroenterology 2013, 108: 1360. PMID: 23711627, PMCID: PMC5388854, DOI: 10.1038/ajg.2013.148.Peer-Reviewed Original ResearchConceptsEarly chronic pancreatitisNegative predictive valueChronic pancreatitisPancreatic function testingPositive predictive valueHistologic evidenceFunction testingPredictive valuePancreatic imagingTertiary care institutionMedian followPositive patientsRetrospective reviewPancreatic functionMedical recordsPancreatitisPatientsDiagnostic accuracyCharacteristic symptomsCare institutionsFollowSubsequent developmentImagingEvidenceSymptoms
2007
Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia
Manoach D, Ketwaroo G, Polli F, Thakkar K, Barton J, Goff D, Fischl B, Vangel M, Tuch D. Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia. NeuroImage 2007, 37: 599-610. PMID: 17590354, DOI: 10.1016/j.neuroimage.2007.04.062.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexDiffusion tensor imagingWhite matterVolitional saccadesCingulate cortexFractional anisotropySaccadic latencyMicrostructural integrityLonger saccadic latenciesRight hemisphereCingulate white matterWhite matter abnormalitiesAnterior cingulum bundleOcular motor controlFrontal eye fieldMedicated schizophrenia outpatientsSaccadic eye movementsPosterior parietal cortexInter-individual variabilityMedicated schizophreniaHealthy controlsProlonged latencyCortical componentsSurface-based coordinate systemEye field