2019
Rational Use of Pancreatic Enzymes for Pancreatic Insufficiency and Pancreatic Pain
Ketwaroo G, Graham D. Rational Use of Pancreatic Enzymes for Pancreatic Insufficiency and Pancreatic Pain. Advances In Experimental Medicine And Biology 2019, 1148: 323-343. PMID: 31482505, PMCID: PMC6913179, DOI: 10.1007/978-981-13-7709-9_14.Peer-Reviewed Original ResearchConceptsPancreatic insufficiencyPancreatic enzymesPancreatic painPancreatic secretionEndogenous pancreatic secretionTreatment of malabsorptionProton pump inhibitorsEnteric-coated formulationCoated formulationPump inhibitorsSuccessful therapySuboptimal effectNutritional deficitsPainDistal intestineNutritional deficienciesRational useInsufficiencyMalabsorptionGood responseTherapySecretionIntestineEnteric coatingDigestive contents
2018
Enzyme therapy for functional bowel disease‐like post‐prandial distress
Graham D, Ketwaroo G, Money M, Opekun A. Enzyme therapy for functional bowel disease‐like post‐prandial distress. Journal Of Digestive Diseases 2018, 19: 650-656. PMID: 30101562, PMCID: PMC6910206, DOI: 10.1111/1751-2980.12655.Peer-Reviewed Original ResearchMeSH KeywordsEnzyme TherapyGastrointestinal AgentsHumansIrritable Bowel SyndromePancreasPostprandial PeriodConceptsIrritable bowel syndromeBowel syndromeDiarrhea-predominant irritable bowel syndromeRandomized placebo-controlled trialDouble-blinded randomizedPost-prandial distressPost-prandial symptomsPlacebo-controlled studyPlacebo-controlled trialFeeling of fullnessAbdominal distensionGastrointestinal symptomsMulti-enzyme preparationUnknown etiologyDisaccharidase deficiencySymptom responseCommon complaintRecent trialsClinical trialsSpecific symptomsCombination drugsEnzyme therapyNarrative reviewSuccessful useSymptoms