2017
Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis
Kothari D, Ketwaroo G, Sawhney M, Freedman S, Sheth S. Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis. Pancreas 2017, 46: 770-775. PMID: 28609365, DOI: 10.1097/mpa.0000000000000829.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersCross-Over StudiesEndoscopes, GastrointestinalEndoscopy, GastrointestinalEndosonographyFeasibility StudiesFemaleHumansMaleMiddle AgedPancreatic Function TestsPancreatic JuicePancreatitis, ChronicPredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsSecretinTime FactorsWorkflowConceptsChronic pancreatitisPeak bicarbonate concentrationPancreatic function testsEndoscopic ultrasonographyFunction testsPoor concordanceProspective crossover studyPancreatic function testingFunctional testsBicarbonate concentrationPeak bicarbonateSecretin testingCrossover studyFunction testingTest concordanceDiscordant findingsFunctional assessmentPatientsImproved concordancePancreatitisSignificant correlationUltrasonographyConcordanceFeasible testCutoff
2015
Approach to Patients With Suspected Chronic Pancreatitis
Ketwaroo G, Freedman S, Sheth S. Approach to Patients With Suspected Chronic Pancreatitis. Pancreas 2015, 44: 173-180. PMID: 25675419, DOI: 10.1097/mpa.0000000000000239.Peer-Reviewed Original ResearchConceptsChronic pancreatitisEarly diagnosisSignificant health care burdenSignificant health care resourcesNonspecific abdominal painEarly chronic pancreatitisHealth care burdenHealth care resourcesCurrent diagnostic testsAbdominal painPancreatic changesCare burdenLarge cohortCare resourcesPatientsDiagnostic testsDiagnosisPancreatitisAvailable literaturePainCohort
2012
CFTR dysfunction predisposes to fibrotic liver disease in a murine model
Martin C, Zaman M, Ketwaroo G, Bhutta A, Coronel E, Popov Y, Schuppan D, Freedman S. CFTR dysfunction predisposes to fibrotic liver disease in a murine model. AJP Gastrointestinal And Liver Physiology 2012, 303: g474-g481. PMID: 22679000, PMCID: PMC3423138, DOI: 10.1152/ajpgi.00055.2012.Peer-Reviewed Original ResearchConceptsCystic fibrosis liver diseaseDextran sodium sulfateBile duct injuryPrimary sclerosing cholangitisDuct injuryFibrotic liver diseaseLiver diseaseSclerosing cholangitisCFTR dysfunctionGrowth factorProgressive biliary fibrosisInduction of colitisMononuclear cell inflammationBile duct proliferationEvaluation of therapyWild-type littermatesSmooth muscle actinCFTR functionBiliary fibrosisUlcerative colitisDuct proliferationPeriductal fibrosisSubthreshold dosesPeriductular fibrosisLiver fibrosis