2022
External validation of a model determining risk of neoplastic progression of Barrett’s esophagus in a cohort of U.S. veterans
Nguyen T, Thrift A, Ketwaroo G, Du X, Leon Novelo L, George R, Rosen D, El-Serag H. External validation of a model determining risk of neoplastic progression of Barrett’s esophagus in a cohort of U.S. veterans. Gastrointestinal Endoscopy 2022, 95: 1113-1122. PMID: 34998796, PMCID: PMC9119926, DOI: 10.1016/j.gie.2021.12.034.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaHigh-risk groupEsophageal adenocarcinomaBarrett's esophagusBE patientsDiscriminatory abilityHouston Veterans Affairs Medical CenterVeterans Affairs Medical CenterHGD/esophageal adenocarcinomaRetrospective cohort studyExternal validationExternal validation studyInitial EGDCohort studyConsecutive patientsSmoking statusDysplasia statusRisk groupsMedical CenterHigh riskGeneral populationNew diagnosisPatientsClinical practiceBiopsy sampling
2021
Prevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population
Nguyen T, Thrift A, George R, Rosen D, El-Serag H, Ketwaroo G. Prevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population. Clinical Gastroenterology And Hepatology 2021, 20: e876-e889. PMID: 33839273, PMCID: PMC8900254, DOI: 10.1016/j.cgh.2021.04.008.Peer-Reviewed Original ResearchConceptsBarrett's esophagusIndex esophagogastroduodenoscopyIndefinite dysplasiaBE diagnosisLong-segment Barrett's esophagusProportion of patientsSegment Barrett's esophagusDysplastic Barrett's esophagusLogistic regression modelsBE lengthDefinite dysplasiaHouston VANDBE patientsClose followInitial biopsyDysplasia surveillanceBE patientsEndoscopic samplingRisk factorsOdds ratioEsophagogastroduodenoscopyRetrospective analysisPatientsVeteran populationDysplasia
2016
Risk Profiles for Barrett’s Esophagus Differ between New and Prevalent, and Long- and Short-Segment Cases
Tan M, Murrey-Ittmann J, Nguyen T, Ketwaroo G, El-Serag H, Thrift A. Risk Profiles for Barrett’s Esophagus Differ between New and Prevalent, and Long- and Short-Segment Cases. PLOS ONE 2016, 11: e0169250. PMID: 28036381, PMCID: PMC5201279, DOI: 10.1371/journal.pone.0169250.Peer-Reviewed Original ResearchConceptsSpecialized intestinal metaplasiaShort-segment BELong-segment BEPrimary care controlsH. pylori infectionRisk factorsGERD symptomsElective esophagogastroduodenoscopyEndoscopy controlsCare controlPylori infectionCase definitionBE casesControl groupGastroesophageal reflux disease symptomsMultivariate logistic regression modelFrequent GERD symptomsPrimary care clinicsCross-sectional studyVeterans Affairs centersLogistic regression modelsEligible patientsH2RA useMedication useCare clinics
2015
Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective
Sengupta N, Ketwaroo G, Bak D, Kedar V, Chuttani R, Berzin T, Sawhney M, Pleskow D. Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective. Gastrointestinal Endoscopy 2015, 82: 443-448. PMID: 25887715, DOI: 10.1016/j.gie.2015.01.033.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaLow-grade dysplasiaRadiofrequency ablationIntramucosal carcinomaRecurrent dysplasiaEndoscopic therapyIntestinal metaplasiaBE dysplasiaEffective endoscopic therapyEradication of dysplasiaSafety of cryotherapyTertiary care centerBarrett's esophagus dysplasiaRFA sessionsSalvage cryotherapyCohort studySecondary outcomesHiatal herniaSingle centerInitial eradicationRetrospective natureEffective treatmentPatientsCryotherapyDysplasia