2022
Brain-behavior relationships of simulated naturalistic automobile driving under the influence of acute cannabis intoxication: A double-blind, placebo-controlled study
Meda S, Stevens M, Boer E, Boyle C, Book G, Ward N, Pearlson G. Brain-behavior relationships of simulated naturalistic automobile driving under the influence of acute cannabis intoxication: A double-blind, placebo-controlled study. 2022 DOI: 10.26828/cannabis.2022.02.000.32.Peer-Reviewed Original ResearchBrain-behavior relationshipsEffects of cannabisFunctional MRICar followingMotion-sensitive visual cortexSpecific driving skillsInferior frontal gyrusSuperior temporal gyrusFrequent cannabis usersComplex everyday activitiesGroup independent component analysisInfluence of cannabisAcute cannabis intoxicationBehavioral factorsKey brain areasIndependent component analysisFrontal gyrusDriving skillsBehavior factorsTemporal gyrusDifferent driving behaviorsSafe overtakingCannabis usersConnectivity differencesFMRI data
2017
92. Peripheral Oxytocin and Vasopressin Modulates Regional Brain Activity Differently in Men and Women With Schizophrenia
Rubin L, Li S, Yao L, Keedy S, Reilly J, Hill S, Bishop J, Carter S, Pournajafi-Nazarloo H, Drogos L, Gershon E, Pearlson G, Tamminga C, Clementz B, Keshavan M, Lui S, Sweeney J. 92. Peripheral Oxytocin and Vasopressin Modulates Regional Brain Activity Differently in Men and Women With Schizophrenia. Schizophrenia Bulletin 2017, 43: s50-s50. PMCID: PMC5475587, DOI: 10.1093/schbul/sbx021.131.Peer-Reviewed Original ResearchHigher AVP levelsHigher ALFFMale patientsCerebellar cortexFrontal cortexArginine vasopressinHigher OT levelsPosterior cingulateOT levelsFemale patientsLower ALFFAVP levelsPoor verbal fluencyHealthy individualsRegional cerebral functionSpontaneous neuronal activitySex-dependent mannerAVP serum concentrationsBrain activityRegional brain activityVerbal fluencyEmotion processingSuperior temporal gyrusClinical associationsSerum concentrations
1997
Superior temporal gyrus and planum temporale in schizophrenia: A selective review
Pearlson G. Superior temporal gyrus and planum temporale in schizophrenia: A selective review. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1997, 21: 1203-1229. PMID: 9460087, DOI: 10.1016/s0278-5846(97)00159-0.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusPlanum temporaleTemporal gyrusNon-human primate researchPET/fMRIFormal thought disorderFunctional pathologySchizophrenic patientsAuditory hallucinationsTemporolimbic areasNeocortical regionsStructural abnormalitiesBrain regionsNeocortical networksExperience hallucinationsFunctional studiesCortical networksNormal asymmetrySchizophreniaThought disorderPatientsNormal structureVolume reductionGyrusPrimate researchSmall planum temporale volume in Down's syndrome: a volumetric MRI study
Frangou S, Aylward E, Warren A, Sharma T, Barta P, Pearlson G. Small planum temporale volume in Down's syndrome: a volumetric MRI study. American Journal Of Psychiatry 1997, 154: 1424-1429. PMID: 9326826, DOI: 10.1176/ajp.154.10.1424.Peer-Reviewed Original ResearchConceptsPlanum temporale volumeSuperior temporal gyrusDown syndromeTemporal gyrusSyndrome patientsBrain volumePlanum temporaleMagnetic resonance imaging (MRI) measuresCommunity-dwelling patientsStructural brain abnormalitiesVolumetric MRI studyTotal brain volumeDown syndrome patientsHealthy comparison subjectsWhole brain volumeVolumetric magnetic resonance imaging (MRI) measuresAnatomic substrateBrain abnormalitiesHealthy subjectsComparison subjectsMRI studiesVolume deficitsSyndromeGyrusImaging measuresQuantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls
Barta P, Powers R, Aylward E, Chase G, Harris G, Rabins P, Tune L, Pearlson G. Quantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls. Psychiatry Research 1997, 68: 65-75. PMID: 9104754, DOI: 10.1016/s0925-4927(96)02751-5.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingOnset schizophreniaAlzheimer's diseaseNormal controlsMRI volume changesLate-onset schizophreniaLateral temporal lobe structuresNon-cognitive symptomsModerate cognitive impairmentTemporal lobe structuresAnterior superior temporal gyrusNormal elderly controlsMedial temporal regionsSuperior temporal gyrusPatient groupSTG volumeAD patientsElderly controlsCognitive impairmentResonance imagingTemporal gyrusTemporal regionsPatientsLobe structuresDiseaseMedial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder
Pearlson G, Barta P, Powers R, Menon R, Richards S, Aylward E, Federman E, Chase G, Petty R, Tien A. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry 1997, 41: 1-14. PMID: 8988790, DOI: 10.1016/s0006-3223(96)00373-3.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusAnterior superior temporal gyrusBipolar disorderSchizophrenic patientsSuperior temporal gyral volumeMagnetic resonance imaging studyTemporal lobe changesMedial temporal structuresRight anterior superior temporal gyrusResonance imaging studyGlobal brain measuresPosterior superior temporal gyrusGyral volumeHealthy controlsMRI measuresTemporal lobeBipolar patientsBipolar subjectsNormal controlsImaging studiesTemporal gyrusPatientsSchizophreniaBilateral volumesBrain measures
1996
Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects
Tune L, Barta P, Wong D, Powers R, Pearlson G, Tien A, Wagner H. Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects. Psychiatry Research 1996, 67: 155-158. PMID: 8876015, DOI: 10.1016/0925-4927(96)02728-x.Peer-Reviewed Original ResearchConceptsSuperior temporal gyral volumeSuperior temporal gyrusPositron emission tomographyGyral volumeTemporal gyrusNormal groupSchizophrenic groupStriatal D2 receptor densityChronic schizophrenic subjectsRight superior temporal gyrusD2 receptor densityDopamine D2 receptorsStructural neuroimaging techniquesControl subjectsD2 receptorsReceptor densityNormal subjectsPET scansResonance imagingEmission tomographySchizophrenic subjectsBmax valuesNeuroimaging techniquesGyrusReceptor quantificationExploratory factor analysis of MRI brain structure measures in schizophrenia
Tien A, Eaton W, Schlaepfer T, McGilchrist I, Menon R, Richard P, Aylward E, Barta P, Strauss M, Pearlson G. Exploratory factor analysis of MRI brain structure measures in schizophrenia. Schizophrenia Research 1996, 19: 93-101. PMID: 8789907, DOI: 10.1016/0920-9964(96)88520-3.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusSchizophrenia groupNormal groupTemporal gyrusStructural brain abnormalitiesLateral temporal lobe structuresBrain volume measuresTemporal lobe structuresSpecific brain regionsPosterior superior temporal gyrusBrain structure measuresBasal gangliaBrain abnormalitiesCortical greyEntorhinal cortexBrain regionsSchizophrenic subjectsNeuropsychiatric dataLobe structuresSchizophreniaSignificant differencesSignificant correlationGray regionGyrusFactor structure
1995
Posterior superior temporal gyrus in schizophrenia: grey matter changes and clinical correlates
Menon R, Barta P, Aylward E, Richards S, Vaughn D, Tien A, Harris G, Pearlson G. Posterior superior temporal gyrus in schizophrenia: grey matter changes and clinical correlates. Schizophrenia Research 1995, 16: 127-135. PMID: 7577766, DOI: 10.1016/0920-9964(94)00067-i.Peer-Reviewed Original Research