2023
Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth
Kohler R, Lichenstein S, Cheng A, Holmes A, Bzdok D, Pearlson G, Yip S. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 407-416. PMID: 38052266, PMCID: PMC11149944, DOI: 10.1016/j.bpsc.2023.11.008.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDisruptive behavior disordersAnterior cingulate responsesLatent dimensionsAnticipatory reward processingDeficit hyperactivity disorderSingle latent dimensionRisk-taking behaviorNegative urgencyExecutive functionIndividual differencesNeurobiological domainsReward anticipationCingulate responseReward processingAdolescent brainCognitive developmentNeural substratesHyperactivity disorderDevelopmental trajectoriesEarly adolescenceMultivariate patternsReward processesBehavioral variablesBehavior disorder
2014
Relationships between Reward Sensitivity, Risk-Taking and Family History of Alcoholism during an Interactive Competitive fMRI Task
Yarosh HL, Hyatt CJ, Meda SA, Jiantonio-Kelly R, Potenza MN, Assaf M, D.Pearlson G. Relationships between Reward Sensitivity, Risk-Taking and Family History of Alcoholism during an Interactive Competitive fMRI Task. PLOS ONE 2014, 9: e88188. PMID: 24505424, PMCID: PMC3913753, DOI: 10.1371/journal.pone.0088188.Peer-Reviewed Original ResearchConceptsVentral striatal activationNeural correlatesImpulsivity measuresStriatal activationFHN individualsFunctional magnetic resonance imaging (fMRI) taskVentral striatum activationSelf-report measuresImpulsivity-related measuresFunctional magnetic resonanceRisk-taking scoresReward-related networksAlcohol-dependent individualsNeural underpinningsPunishment sensitivityReward responsivenessReward sensitivityFMRI taskReward processingStriatum activationSocial tasksFHP individualsMonetary rewardsAddictive behaviorsAxis I Disorders