2009
Subregional neuroanatomical change as a biomarker for Alzheimer's disease
Holland D, Brewer J, Hagler D, Fennema-Notestine C, Dale A, Weiner M, Thal L, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Gamst A, Potter W, Montine T, Anders D, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Shaw L, Lee V, Korecka M, Crawford K, Neu S, Harvey D, Kornak J, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Vorobik R, Quinn J, Schneider L, Pawluczyk S, Spann B, Fleisher A, Vanderswag H, Heidebrink J, Lord J, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Mintun M, Schneider S, Marson D, Griffith R, Badger B, Grossman H, Tang C, Stern J, deToledo-Morrell L, Shah R, Bach J, Duara R, Isaacson R, Strauman S, Albert M, Pedroso J, Toroney J, Rusinek H, de Leon M, De Santi S, Doraiswamy P, Petrella J, Aiello M, Clark C, Pham C, Nunez J, Smith C, Given C, Hardy P, DeKosky S, Oakley M, Simpson D, Ismail M, Porsteinsson A, McCallum C, Cramer S, Mulnard R, McAdams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Laubinger M, Bartzokis G, Silverman D, Lu P, Fletcher R, Parfitt F, Johnson H, Farlow M, Herring S, Hake A, van Dyck C, MacAvoy M, Bifano L, Chertkow H, Bergman H, Hosein C, Black S, Graham S, Caldwell C, Feldman H, Assaly M, Hsiung G, Kertesz A, Rogers J, Trost D, Bernick C, Gitelman D, Johnson N, Mesulam M, Sadowsky C, Villena T, Mesner S, Aisen P, Johnson K, Behan K, Sperling R, Rentz D, Johnson K, Rosen A, Tinklenberg J, Ashford W, Sabbagh M, Connor D, Obradov S, Killiany R, Norbash A, Obisesan T, Jayam-Trouth A, Wang P, Auchus A, Huang J, Friedland R, DeCarli C, Fletcher E, Carmichael O, Kittur S, Mirje S, Johnson S, Borrie M, Lee T, Asthana S, Carlsson C, Potkin S, Highum D, Preda A, Nguyen D, Tariot P, Hendin B, Scharre D, Kataki M, Beversdorf D, Zimmerman E, Celmins D, Brown A, Gandy S, Marenberg M, Rovner B, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Pare N, Williamson J, Sink K, Potter H, Raj B, Giordano A, Ott B, Wu C, Cohen R, Wilks K, Safirstein B. Subregional neuroanatomical change as a biomarker for Alzheimer's disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 20954-20959. PMID: 19996185, PMCID: PMC2791580, DOI: 10.1073/pnas.0906053106.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentAlzheimer's diseaseClinical trialsOutcome measuresCerebral volume changesDisease-modifying effectsCerebral structural changesDisease-modifying agentsSerial MRI scansTemporal lobe cortical regionsSensitive outcome measuresDisease-related changesBrain atrophyNeuroprotective effectsAD pathologyHealthy controlsSubregional atrophyCortical changesEarly diagnosisNeuroanatomical changesCortical thicknessNormal subjectsMRI scansVentricular volumeClinical practice
2000
Measurement of the planum temporale (PT) on magnetic resonance imaging scans: temporal PT alone and with parietal extension
Honeycutt N, Musick A, Barta P, Pearlson G. Measurement of the planum temporale (PT) on magnetic resonance imaging scans: temporal PT alone and with parietal extension. Psychiatry Research 2000, 98: 103-116. PMID: 10762736, DOI: 10.1016/s0925-4927(00)00043-3.Peer-Reviewed Original Research
1998
SPECT brain blood flow changes with continuous ligand infusion during previously-learned WCST performance
Tien A, Schlaepfer T, Orr W, Pearlson G. SPECT brain blood flow changes with continuous ligand infusion during previously-learned WCST performance. Psychiatry Research 1998, 82: 47-52. PMID: 9645550, DOI: 10.1016/s0925-4927(98)00003-1.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TestBrain blood flow changesBlood flow changesInferior parietal cortexBrain activation patternsBilateral inferior frontalBlood flowNormal subjectsTemporal cortexAnterior cingulateParietal cortexCard Sorting TestInferior frontalInfusionWCST performanceFlow changesCortexSorting TestHippocampusCaudateCingulate
1996
Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects
Tune L, Barta P, Wong D, Powers R, Pearlson G, Tien A, Wagner H. Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects. Psychiatry Research 1996, 67: 155-158. PMID: 8876015, DOI: 10.1016/0925-4927(96)02728-x.Peer-Reviewed Original ResearchConceptsSuperior temporal gyral volumeSuperior temporal gyrusPositron emission tomographyGyral volumeTemporal gyrusNormal groupSchizophrenic groupStriatal D2 receptor densityChronic schizophrenic subjectsRight superior temporal gyrusD2 receptor densityDopamine D2 receptorsStructural neuroimaging techniquesControl subjectsD2 receptorsReceptor densityNormal subjectsPET scansResonance imagingEmission tomographySchizophrenic subjectsBmax valuesNeuroimaging techniquesGyrusReceptor quantification
1993
Dopamine receptor density measured by C-11 raclopride and NMSP in the same schizophrenic patients and normal subjects
Wong D, Tune L, Shaya E, Pearlson G, Yung B, Dannals R, Wilson A, Ravert H, Wagner H, Gjedde A. Dopamine receptor density measured by C-11 raclopride and NMSP in the same schizophrenic patients and normal subjects. Schizophrenia Research 1993, 9: 212. DOI: 10.1016/0920-9964(93)90458-u.Peer-Reviewed Original Research
1987
Increased ventricle-to-brain ratio in late-onset schizophrenia
Rabins P, Pearlson G, Jayaram G, Steele C, Tune L. Increased ventricle-to-brain ratio in late-onset schizophrenia. American Journal Of Psychiatry 1987, 144: 1216-1218. PMID: 3631322, DOI: 10.1176/ajp.144.9.1216.Peer-Reviewed Original Research