2019
Blood-based protein mediators of senility with replications across biofluids and cohorts
Royall D, Palmer R, Weiner M, Aisen P, Weiner M, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Montine T, Jimenez G, Donohue M, Gessert D, Harless K, Salazar J, Cabrera Y, Walter S, Hergesheimer L, Harvey D, Lee V, Korecka M, Figurski M, Thal L, Thal L, Buckholtz N, Snyder P, Albert M, Frank R, Quinn J, Silbert L, Lind B, Kaye J, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Ziolkowski J, Heidebrink J, Lord J, Mason S, Albers C, Knopman D, Johnson K, Villanueva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass J, Doody R, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Yeh R, Ances B, Morris J, Winkfield D, Carroll M, Oliver A, Creech M, Mintun M, Schneider S, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Grossman H, Mitsis E, Shah R, Lamar M, Samuels P, Duara R, Greig-Custo M, Rodriguez R, Onyike C, D’Agostino D, Sheikh S, Singleton-Garvin J, Ulysse A, Gaikwad M, Doraiswamy P, Petrella J, James O, Borges-Neto S, Wong T, Coleman E, Karlawish J, Wolk D, Vaishnavi S, Clark C, Arnold S, Smith C, Jicha G, Hardy P, Khouli R, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Martin K, Kowalksi N, Keltz M, Goldstein B, Makino K, Ismail M, Brand C, Thai G, Pierce A, Yanez B, Sosa E, Witbracht M, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Woo E, Silverman D, Teng E, Kremen S, Apostolova L, Tingus K, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, Varma P, Chertkow H, Bergman H, Hosein C, Kielb M, Black S, Stefanovic B, Heyn C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Pavlosky W, Rachinsky I, Drost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Chao S, Lane B, Rosen A, Tinklenberg J, Zamrini E, Belden C, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Oyonumo N, Allard J, Ogunlana O, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Tariot P, Burke A, Hetelle J, DeMarco K, Trncic N, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Tarawneh R, Zimmerman E, Celmins D, Hart D, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Yang M, Mintz A, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Lee A, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Pasternak S, Rogers J, Pomara N, Hernando R, Sarrael A, Miller D, Smith K, Koleva H, Nam K, Shim H, Schultz S, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Leach C, Raj B, Fargher K, Bodge C. Blood-based protein mediators of senility with replications across biofluids and cohorts. Brain Communications 2019, 2: fcz036. PMID: 32954311, PMCID: PMC7425523, DOI: 10.1093/braincomms/fcz036.Peer-Reviewed Original ResearchDementia severityTexas Alzheimer's ResearchCare ConsortiumDisease Neuroimaging InitiativeAlzheimer's ResearchBlood-based protein biomarkersBody mass indexFollicle-stimulating hormoneLow-density lipoproteinAlzheimer's Disease Neuroimaging InitiativeLatent dementia phenotypeMass indexAge-specific effectsAge effectsDementia phenotypePancreatic polypeptideCognitive frailtyDisease processCognitive declineSeverityProtein mediatorsBiomarkersUnique effectsMediatorsCognitive performance measures
2010
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
Ho A, Stein J, Hua X, Lee S, Hibar D, Leow A, Dinov I, Toga A, Saykin A, Shen L, Foroud T, Pankratz N, Huentelman M, Craig D, Gerber J, Allen A, Corneveaux J, Stephan D, DeCarli C, DeChairo B, Potkin S, Jack C, Weiner M, Raji C, Lopez O, Becker J, Carmichael O, Thompson P, Weiner M, Thal L, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Gamst A, Potter W, Montine T, Anders D, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Harvey D, Gamst A, Kornak J, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Vorobik R, Quinn J, Schneider L, Pawluczyk S, Spann B, Fleisher A, Vanderswag H, Heidebrink J, Lord J, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Mintun M, Schneider S, Marson D, Griffith R, Badger B, Grossman H, Tang C, Stern J, deToledo-Morrell L, Shah R, Bach J, Duara R, Isaacson R, Strauman S, Albert M, Pedroso J, Toroney J, Rusinek H, de Leon M, De Santi S, Doraiswamy P, Petrella J, Aiello M, Clark C, Pham C, Nunez J, Smith C, Given C, Hardy P, DeKosky S, Oakley M, Simpson D, Ismail M, Porsteinsson A, McCallum C, Cramer S, Mulnard R, McAdams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Laubinger M, Bartzokis G, Silverman D, Lu P, Fletcher R, Parfitt F, Johnson H, Farlow M, Herring S, Hake A, van Dyck C, MacAvoy M, Bifano L, Chertkow H, Bergman H, Hosein C, Black S, Graham S, Caldwell C, Feldman H, Assaly M, Hsiung G, Kertesz A, Rogers J, Trost D, Bernick C, Gitelman D, Johnson N, Mesulam M, Sadowsky C, Villena T, Mesner S, Aisen P, Johnson K, Behan K, Sperling R, Rentz D, Johnson K, Rosen A, Tinklenberg J, Ashford W, Sabbagh M, Connor D, Obradov S, Killiany R, Norbash A, Obisesan T, Jayam-Trouth A, Wang P, Auchus A, Huang J, Friedland R, DeCarli C, Fletcher E, Carmichael O, Kittur S, Mirje S, Johnson S, Borrie M, Lee T, Asthana S, Carlsson C, Potkin S, Highum D, Preda A, Nguyen D, Tariot P, Hendin B, Scharre D, Kataki M, Beversdorf D, Zimmerman E, Celmins D, Brown A, Gandy S, Marenberg M, Rovner B, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Pare N, Williamson J, Sink K, Potter H, Raj B, Giordano A, Ott B, Wu C, Cohen R, Wilks K. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 8404-8409. PMID: 20404173, PMCID: PMC2889537, DOI: 10.1073/pnas.0910878107.Peer-Reviewed Original ResearchConceptsBody mass indexRisk allele carriersBrain volume differencesBrain atrophyDisease Neuroimaging InitiativeAllele carriersVolume deficitsElevated body mass indexHigher body mass indexRisk allelesSignificant volume deficitsStructural brain atrophyRegional brain volume differencesBrain volume deficitsGreater waist circumferenceReduced brain volumeHealthy elderly subjectsWhite matter hyperintensitiesObesity-associated (FTO) geneAlzheimer's Disease Neuroimaging InitiativeWaist circumferenceMass indexVolume differencesCholesterol levelsObese persons