2024
Cerebral Blood Flow Changes and Neuroticism in Late-Life Depression
Anderson T, Steffens D, Wang L, Pearlson G. Cerebral Blood Flow Changes and Neuroticism in Late-Life Depression. American Journal Of Geriatric Psychiatry 2024, 32: s49-s50. DOI: 10.1016/j.jagp.2024.01.121.Peer-Reviewed Original ResearchMontgomery Asberg Depression Rating ScaleLate-life depressionAsberg Depression Rating ScaleLeft putamenFrontal poleLow neuroticismGroup differencesDecreased CBFLLD subjectsDepression severityDepression groupLLD groupCerebral blood flowNever-depressed control subjectsNever-depressed healthy controlsNEO Personality InventoryNever-depressed groupDepression Rating ScaleNeuroticism personality traitFrontal lobe structuresGroup effectBrain morphological changesT1-weighted MPRAGE imagesHealthy controlsSignificant group effect
2023
Association between perceived stress and brain structure volumes in older adults without late-life depression: a key role for the thalamus?
Anam A, Wang L, Pearlson G. Association between perceived stress and brain structure volumes in older adults without late-life depression: a key role for the thalamus? American Journal Of Geriatric Psychiatry 2023, 31: s61-s62. DOI: 10.1016/j.jagp.2022.12.221.Peer-Reviewed Original ResearchLate-life depressionThalamus volumeEarly life stressHC groupLLD groupPrefrontal cortexOlder adultsAnterior cingulateBrain volumeControl groupDuke Depression Evaluation ScheduleMontgomery-Asberg Depression Rating ScaleSimilar findingsHealthy control subjectsDepression Rating ScaleIntracranial brain volumeSignificant differencesSignificant correlationConnecticut Health CenterDorsal anterior cingulateSubcortical brain regionsStandardized acquisition protocolBrain structure volumesVentral anterior cingulateInstitutional review board