2020
Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults
Kahleova H, Petersen KF, Shulman GI, Alwarith J, Rembert E, Tura A, Hill M, Holubkov R, Barnard ND. Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults. JAMA Network Open 2020, 3: e2025454. PMID: 33252690, PMCID: PMC7705596, DOI: 10.1001/jamanetworkopen.2020.25454.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAdultAgedBlood GlucoseBody CompositionBody WeightCholesterolCholesterol, HDLCholesterol, LDLC-PeptideDiet, Fat-RestrictedDiet, VeganEnergy IntakeEnergy MetabolismFemaleGlycated HemoglobinHepatocytesHumansInsulinInsulin ResistanceIntra-Abdominal FatLipid MetabolismLiverMaleMiddle AgedMuscle Fibers, SkeletalMuscle, SkeletalObesityOverweightPostprandial PeriodProton Magnetic Resonance SpectroscopyTriglyceridesConceptsLow-fat vegan dietHomeostasis model assessment indexIntramyocellular lipid levelsModel assessment indexIntervention groupLipid levelsBody weightInsulin resistancePostprandial metabolismVegan dietOverweight adultsDietary interventionInsulin sensitivityThermic effectControl groupPlant-based dietary interventionDual X-ray absorptiometryInsulin resistance leadExcess body weightInsulin sensitivity indexType 2 diabetesMajor health problemProton magnetic resonance spectroscopyX-ray absorptiometrySubset of participants
1998
Effect of insulin on glycerol production in obese adolescents
Robinson C, Tamborlane W, Maggs D, Enoksson S, Sherwin R, Silver D, Shulman G, Caprio S. Effect of insulin on glycerol production in obese adolescents. American Journal Of Physiology 1998, 274: e737-e743. PMID: 9575836, DOI: 10.1152/ajpendo.1998.274.4.e737.Peer-Reviewed Original ResearchConceptsNet lipid oxidationObese adolescentsLean adultsGlycerol turnoverTwo-step euglycemic-hyperinsulinemic clampFree fatty acid concentrationsBody fat massEuglycemic hyperinsulinemic clampSensitivity of adipocytesEffect of insulinAction of insulinObese groupLean subjectsInsulin resistanceAdipose massPlasma insulinFatty acid concentrationsAdolescent obesityFat massLean adolescentsImpaired stimulationPhysiological incrementsFFA levelsGlucose metabolismIndirect calorimetry
1985
Metabolic Response to Three Years of Continuous, Basal Rate Intravenous Insulin Infusion in Type II Diabetic Patients*
BLACKSHEAR P, SHULMAN G, ROUSSELL A, NATHAN D, MINAKER K, ROWE J, ROBBINS D, COHEN A. Metabolic Response to Three Years of Continuous, Basal Rate Intravenous Insulin Infusion in Type II Diabetic Patients*. The Journal Of Clinical Endocrinology & Metabolism 1985, 61: 753-760. PMID: 3897260, DOI: 10.1210/jcem-61-4-753.Peer-Reviewed Original ResearchConceptsType II diabetic patientsII diabetic patientsInsulin clamp studiesDiabetic patientsInsulin infusionClamp studiesObese type II diabetic patientsEuglycemic insulin clamp studiesInfusion pumpVitreous fluorescein concentrationHemoglobin A1c levelsMonths of treatmentGlucose disposal rateIntravenous insulin infusionNormal glycemic controlSerum triglyceride concentrationBlood glucose levelsInfusion of insulinImplantable infusion pumpInsulin infusion pumpA1c levelsGlycemic controlSignificant hypoglycemiaImmunoreactive insulinPlasma glucose