2024
Vascular Endothelial Cells Derived from Transgene-Free Pig Induced Pluripotent Stem Cells for Vascular Tissue Engineering
Batty L, Park J, Qin L, Riaz M, Lin Y, Xu Z, Gao X, Li X, Lopez C, Zhang W, Hoareau M, Fallon M, Huang Y, Luo H, Luo J, Ménoret S, Li P, Jiang Z, Smith P, Sachs D, Tellides G, Anegon I, Pober J, Liu P, Qyang Y. Vascular Endothelial Cells Derived from Transgene-Free Pig Induced Pluripotent Stem Cells for Vascular Tissue Engineering. Acta Biomaterialia 2024 PMID: 39681154, DOI: 10.1016/j.actbio.2024.12.033.Peer-Reviewed Original ResearchInduced pluripotent stem cellsVascular tissue engineeringPig induced pluripotent stem cellsPluripotent stem cellsEndothelial cellsLarge animal modelStem cellsAnimal modelsTissue engineeringInferior vena cava graftHuman induced pluripotent stem cellsEffective differentiation protocolsPreclinical large animal modelExpression of endothelial markersCell-based therapiesExtensive preclinical testingPig endothelial cellsFunctional endothelial cellsIn vivo functional studiesTreatment of cardiovascular diseasesVascular endothelial cellsTissue engineering therapiesTransplant therapeuticsEfficacy of tissueImmunodeficient rats
1998
Transplantation Models in Human/Mouse Chimeras
Tellides G, Kirkiles N, Tereb D, Schechner J, Wilson J, Lorber M, Pober J. Transplantation Models in Human/Mouse Chimeras. 1998, 615-626. DOI: 10.1007/978-3-642-72140-3_63.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsSevere combined immunodeficiencyHuman/mouse chimerasTransplantation modelImmune responseB lymphocytesNatural killer cell activityMouse chimerasHuman peripheral blood mononuclear cellsEndothelial cellsKiller cell activityHuman peripheral blood leukocytesCellular immune responsesBlood mononuclear cellsHuman immune responsePeripheral blood leukocytesHuman mononuclear leukocytesPig endothelial cellsHuman allogeneicPig graftsArtery graftAdoptive transferNK cellsMononuclear cellsHost mice