2023
Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials
Corren J, Menzies-Gow A, Chupp G, Israel E, Korn S, Cook B, Ambrose C, Hellqvist Å, Roseti S, Molfino N, Llanos J, Martin N, Bowen K, Griffiths J, Parnes J, Colice G. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 13-24. PMID: 37015033, PMCID: PMC10870853, DOI: 10.1164/rccm.202210-2005oc.Peer-Reviewed Original ResearchConceptsAsthma exacerbation rateUncontrolled asthmaExacerbation rateSecondary outcomesClinical trialsOverall populationRelevant subgroupsMeaningful reductionEfficacy of tezepelumabExacerbation-related hospitalizationsSafety of tezepelumabPlacebo-controlled trialEmergency department visitsInflammatory biomarker levelsNitric oxide levelsAdverse eventsAllergy statusBaseline bloodClinical characteristicsDepartment visitsPooled analysisNAVIGATOR trialBiomarker levelsOxide levelsTezepelumab
2017
Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study
Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Salem W, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. The Journals Of Gerontology Series B 2017, 73: 1501-1513. PMID: 28482106, PMCID: PMC6178963, DOI: 10.1093/geronb/gbx051.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDisabled PersonsExerciseFemaleHumansMaleMobility LimitationProgram EvaluationSocial ParticipationConceptsMajor mobility disabilityPhysical activity programMobility disabilityPA interventionsActivity programStandardized walking testHealth education interventionHigh social participationLimited social participationStructured PAWalking testLower incidenceSocial participationSedentary adultsEducation interventionOlder adultsInterventionDisabilityBaselineWeeksMonthsLife studiesAdultsSignificant interventionHigh levels
2016
Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study
Aubertin-Leheudre M, Anton S, Beavers D, Manini T, Fielding R, Newman A, Church T, Kritchevsky S, Conroy D, McDermott M, Botoseneanu A, Hauser M, Pahor M, Gill T, Fragoso C, Fielding R, Hauser M, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler M, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. Journal Of The American Medical Directors Association 2016, 18: 312-319. PMID: 27914851, PMCID: PMC5366275, DOI: 10.1016/j.jamda.2016.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBody Mass IndexFemaleHumansMaleMetabolic SyndromeMuscle StrengthObesityRisk FactorsWaist CircumferenceConceptsDiastolic blood pressureBlood pressureOlder adultsWaist circumferenceRisk factorsMetabolic disease risk factorsHigher diastolic blood pressureAbdominal obesity criteriaObese older adultsMetabolic risk factorsMetabolic syndrome criteriaDisease risk factorsBody mass indexCardiometabolic disease riskPresence of dynapeniaAged 70Obesity criteriaSyndrome criteriaLifestyle interventionMetS criteriaBlood lipidsObese groupMass indexObesity statusMetabolic healthPredictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study
Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW, Investigators L, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kim W, Beard V, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Archives Of Physical Medicine And Rehabilitation 2016, 98: 11-24.e3. PMID: 27568165, PMCID: PMC5183463, DOI: 10.1016/j.apmr.2016.07.019.Peer-Reviewed Original ResearchConceptsPhysical functionPhysical activitySPPB scoreGait speedHigher self-reported physical activityShort Physical Performance Battery scorePhysical activity-related factorsPhysical Performance Battery scoreLower body mass indexModerate-intensity physical activitySelf-reported physical activityOlder adultsBaseline physical functionBody mass indexLower extremity functionStructured physical activityHome-based sessionsHealth education programsActivity-related factorsPredictors of changeMulticenter institutionsLifestyle interventionRelevant health informationBaseline factorsLife studies
2011
The Lifestyle Interventions and Independence for Elders Study: Design and Methods
Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: Design and Methods. The Journals Of Gerontology Series A 2011, 66A: 1226-1237. PMID: 21825283, PMCID: PMC3193523, DOI: 10.1093/gerona/glr123.Peer-Reviewed Original ResearchConceptsMajor mobility disabilityMobility disabilityLifestyle interventionPrimary outcomeElders StudyModerate-intensity physical activity programImportant public health implicationsIntermediate functional outcomesOlder sedentary menPersistent mobility disabilityPhase 3 multicenterSedentary older personsSerious fall injuriesRegular physical activityPublic health priorityPhysical activity programHealth education programsPublic health implicationsSecondary outcomesSedentary menFunctional outcomeFall injuriesHealth priorityPhysical activityDaily living
2008
Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function. New England Journal Of Medicine 2008, 358: 1682-1691. PMID: 18403759, PMCID: PMC2629486, DOI: 10.1056/nejmoa0708801.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAdolescentAdultAgedAged, 80 and overAsthmaBiomarkersBronchial HyperreactivityCase-Control StudiesChildChitinase-3-Like Protein 1FemaleFounder EffectGenetic Predisposition to DiseaseGenotypeGlycoproteinsHumansLectinsMaleMiddle AgedPhenotypePolymorphism, Single NucleotidePulmonary VentilationConceptsSerum YKL-40 levelsYKL-40 levelsLung functionYears of ageBronchial hyperresponsivenessPulmonary functionSingle nucleotide polymorphismsYKL-40Elevated serum YKL-40 levelsBirth cohortChitinase-like protein YKL-40Presence of asthmaProtein YKL-40Risk of asthmaPromoter single nucleotide polymorphismsEuropean descentSubepithelial basement membraneCase-control populationCase patientsAsthma statusAsthmaHigh riskChitinase 3Same single nucleotide polymorphismCHI3L1