2019
Shared and Tissue-Specific Expression Signatures between Bone Marrow from Primary Myelofibrosis and Essential Thrombocythemia
Ishikawa G, Fujiwara N, Hirschfield H, Varricchio L, Hoshida Y, Barosi G, Rosti V, Padilla M, Mazzarini M, Friedman SL, Hoffman R, Migliaccio AR. Shared and Tissue-Specific Expression Signatures between Bone Marrow from Primary Myelofibrosis and Essential Thrombocythemia. Experimental Hematology 2019, 79: 16-25.e3. PMID: 31678370, PMCID: PMC6910948, DOI: 10.1016/j.exphem.2019.10.001.Peer-Reviewed Original ResearchConceptsBone marrowLung fibrosisMyeloproliferative neoplasmsEssential thrombocytopeniaLiver fibrosisPhiladelphia-negative myeloproliferative neoplasmsProtein 1Possible therapeutic targetPrimary myelofibrosis patientsExpression of Id1Extracellular matrix protein 1Poor prognosisIL-8Myelofibrosis patientsEssential thrombocythemiaTherapeutic targetPrimary myelofibrosisFibrosisMegakaryocyte hyperplasiaCholesterol homeostasisBM functionHematopoietic failureMatrix protein 1K-rasPotential target
2017
Elevated serum D-dimer level is associated with an increased risk of acute exacerbation in interstitial lung disease
Ishikawa G, Acquah SO, Salvatore M, Padilla ML. Elevated serum D-dimer level is associated with an increased risk of acute exacerbation in interstitial lung disease. Respiratory Medicine 2017, 128: 78-84. PMID: 28610674, DOI: 10.1016/j.rmed.2017.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlveolitis, Extrinsic AllergicBiomarkersChronic DiseaseDisease ProgressionFemaleFibrin Fibrinogen Degradation ProductsHospitalizationHumansIdiopathic Interstitial PneumoniasIdiopathic Pulmonary FibrosisL-Lactate DehydrogenaseLung Diseases, InterstitialMaleMiddle AgedMortalityOutcome Assessment, Health CarePredictive Value of TestsPrognosisPulmonary EmphysemaRetrospective StudiesRisk FactorsVenous ThromboembolismConceptsElevated serum D-dimer levelsSerum D-dimer levelsInterstitial lung diseaseD-dimer levelsAcute exacerbationRespiratory-related hospitalizationsSerum D-dimerD-dimer measurementVenous thromboembolismCause hospitalizationCause mortalityD-dimerLung diseaseOutcome measuresElevated serum D-dimerCollagen tissue diseasesSubsequent acute exacerbationChronic hypersensitivity pneumonitisSecondary outcome measuresHome oxygen therapyIdiopathic interstitial pneumoniaIdiopathic pulmonary fibrosisPrimary outcome measureSerum lactate dehydrogenaseInterstitial pneumonia