2023
Racial, Ethnic, and Socioeconomic Differences in Food Allergies in the US
Jiang J, Warren C, Brewer A, Soffer G, Gupta R. Racial, Ethnic, and Socioeconomic Differences in Food Allergies in the US. JAMA Network Open 2023, 6: e2318162. PMID: 37314805, PMCID: PMC10267771, DOI: 10.1001/jamanetworkopen.2023.18162.Peer-Reviewed Original ResearchConceptsNon-Hispanic Black individualsNon-Hispanic white individualsParent-reported food allergyFood allergyWhite individualsBlack individualsEpinephrine autoinjector useFood allergy outcomesSurvey-weighted proportionsEmergency department visitsCommon food allergensFood allergy reactionsPopulation-based surveyCross-sectional survey studySimilar symptom presentationsLower ratesAutoinjector useDepartment visitsClinical outcomesPhysician diagnosisAllergy outcomesRepresentative sampleAllergy reactionsMAIN OUTCOMEPrevalence ratesThe emerging role of child life specialists in the pediatric food allergy clinic
Mathew M, Stahl U, Soffer G. The emerging role of child life specialists in the pediatric food allergy clinic. Annals Of Allergy Asthma & Immunology 2023, 131: 296-297. PMID: 37209837, DOI: 10.1016/j.anai.2023.05.013.Peer-Reviewed Original Research
2022
Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies
Maskey A, Wang Z, Chen X, Dunkin D, Yang N, Soffer G, Yuan Q, Li X. Computational analysis to define efficacy & molecular mechanisms of 7, 4’- Dihydroxyflavone on eosinophilic esophagitis: Ex-vivo validation in human esophagus biopsies. Frontiers In Immunology 2022, 13: 1015437. PMID: 36591238, PMCID: PMC9797535, DOI: 10.3389/fimmu.2022.1015437.Peer-Reviewed Original ResearchConceptsLevels of TNFIL-6Abdominal painEosinophilic esophagitisBiopsy samplesAbnormal bowel movementsTreatment of EoEMain treatment optionDihydroxy flavonesSignificant reductionTraditional Chinese medicine practiceDietary eliminationEoE therapyGE refluxSwallowed steroidsBowel movementsEoE patientsEsophageal dysfunctionGI symptomsEosinophilic inflammationImmunological mechanismsSteroid treatmentUpper endoscopyIgE productionChinese medicine practiceSafety Considerations for Natural Products Commonly Used By Patients with Allergic Disease
Soffer G, Shroff P, Horwitz R. Safety Considerations for Natural Products Commonly Used By Patients with Allergic Disease. The Journal Of Allergy And Clinical Immunology In Practice 2022, 10: 3131-3138. PMID: 36174919, DOI: 10.1016/j.jaip.2022.09.025.Peer-Reviewed Original ResearchConceptsConventional medical therapyHealth care providersMedical therapyAllergic diseasesClinical commentaryAdverse reactionsDrug Administration requirementsCare providersSide effectsAlternative medicinePatientsDietary supplementsU.S. FoodAllergyAdministration requirementsMedicinal plantsNatural productsTherapyCliniciansSafety considerationsDiseaseHealth disparities in pediatric food allergy
Tepler E, Wong KH, Soffer GK. Health disparities in pediatric food allergy. Annals Of Allergy Asthma & Immunology 2022, 129: 417-423. PMID: 35476967, DOI: 10.1016/j.anai.2022.04.022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPediatric food allergyFood allergyHealth disparitiesSocioeconomic disparitiesSocioeconomic statusOutcome of childrenLow socioeconomic statusGoogle Scholar databasesAllergen-free foodsLong-term managementAcute managementAllergy careOverall prevalenceFood assistance programsAllergyHealth outcomesScholar databasesGreater riskLiterature searchOriginal research articlesChildrenPossible interventionsPrevalenceCurrent literatureDiagnosisCharacteristics and prevalence of antibiotic allergies in patients with sickle cell disease: A single‐center retrospective study
Wong KH, Soffer GK. Characteristics and prevalence of antibiotic allergies in patients with sickle cell disease: A single‐center retrospective study. American Journal Of Hematology 2022, 97: e247-e249. PMID: 35358357, DOI: 10.1002/ajh.26555.Peer-Reviewed Original Research
2021
A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist
Wong KH, Shapiro ED, Soffer GK. A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist. Clinical Reviews In Allergy & Immunology 2021, 62: 264-271. PMID: 34687445, DOI: 10.1007/s12016-021-08906-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-treatment Lyme disease syndromeChronic Lyme diseaseNon-specific symptomsLyme diseaseDisease syndromeBurgdorferi infectionCurrent Lyme diseaseUse of IVIGIntravenous immunoglobulin treatmentCompletion of therapyMajority of patientsMinority of patientsConstellation of symptomsBorrelia burgdorferi infectionB. burgdorferi infectionBorrelia burgdorferi sensu latoImmunoglobulin treatmentImmune dysregulationAntibiotic therapyMusculoskeletal painBurgdorferi sensu latoCognitive dysfunctionImmune systemInfected IxodesPatientsConcomitant cow's milk and beef food protein–induced enterocolitis syndrome in a young infant
You L, Shafi S, Soffer G. Concomitant cow's milk and beef food protein–induced enterocolitis syndrome in a young infant. Annals Of Allergy Asthma & Immunology 2021, 127: 504-505. PMID: 34153445, DOI: 10.1016/j.anai.2021.06.009.Peer-Reviewed Original ResearchReply to “Increasing diversity in peanut oral immunotherapy research and accessibility”
Soffer G, Afinogenova Y, Factor JM. Reply to “Increasing diversity in peanut oral immunotherapy research and accessibility”. The Journal Of Allergy And Clinical Immunology In Practice 2021, 9: 2133. PMID: 33966875, DOI: 10.1016/j.jaip.2021.02.011.Peer-Reviewed Original ResearchAn integrative medicine review of primary prevention of allergy in pediatrics
Boolchandani H, Horwitz R, Soffer G. An integrative medicine review of primary prevention of allergy in pediatrics. Complementary Therapies In Medicine 2021, 58: 102695. PMID: 33636296, DOI: 10.1016/j.ctim.2021.102695.Peer-Reviewed Original ResearchConceptsAtopic diseasesAllergic diseasesPrimary preventionIntegrative medicineIntegrative medicine approachesLong-term outcomesNarrative review articlePrevention of diseaseMedicine ReviewsCounseling patientsPediatric populationAllergy preventionMedicine approachDiseasePreventionAllergyMedicineReview articlePatientsPregnancyPediatricsPrevalenceSensitizationInfectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients
Shin JJ, Catanzaro J, Yonkof JR, Delmonte O, Sacco K, Shin MS, Reddy S, Whittington PJ, Soffer G, Mustillo PJ, Sullivan KE, Notarangelo LD, Abraham RS, Romberg N, Kang I. Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients. Journal Of Clinical Immunology 2021, 41: 795-806. PMID: 33495902, PMCID: PMC8329305, DOI: 10.1007/s10875-021-00968-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBiomarkersCase-Control StudiesCD40 LigandCD8-Positive T-LymphocytesCellular SenescenceChild, PreschoolGenes, X-LinkedGenetic Association StudiesGenetic Predisposition to DiseaseHumansImmune System DiseasesImmunophenotypingInfectionsPedigreePhenotypePrognosisReceptors, Antigen, T-CellYoung AdultConceptsT cell senescenceCD40L-deficient patientsImmunoglobulin G replacementHealthy controlsT cellsInfectious complicationsCD40L deficiencyT-cell receptor excision circle analysisPneumocystis jirovecii pneumonia prophylaxisCMV-specific proliferationPatient group 2Effector memory CD8Effective prophylactic strategyCytokine release assaysAdult healthy controlsEarly CD8Pneumonia prophylaxisProphylaxis adherenceResultsThree patientsProphylactic antibioticsSenescence-associated moleculesMemory CD8Childhood pneumoniaInfectious exposureRecurrent infectionsImmunoglobulin G food testing
Wong KH, Horwitz R, Soffer GK. Immunoglobulin G food testing. Annals Of Allergy Asthma & Immunology 2021, 126: 611-612. PMID: 33493642, DOI: 10.1016/j.anai.2021.01.022.Commentaries, Editorials and Letters
2020
Successful Management of Eosinophilic Esophagitis Using Traditional Chinese Medicine: A Case Report.
Soffer G, Kaman K, Li XM. Successful Management of Eosinophilic Esophagitis Using Traditional Chinese Medicine: A Case Report. The Yale Journal Of Biology And Medicine 2020, 93: 685-688. PMID: 33380930, PMCID: PMC7757072.Peer-Reviewed Original ResearchConceptsTraditional Chinese medicineEosinophilic esophagitisChinese medicineQuality of lifeComplete remissionTopical steroidsFood eliminationTh2 cytokinesCase reportLabel useEoESuccessful managementEsophagitisTreatmentFurther modalitiesMedicineRemissionPatientsPathophysiologyCytokinesSteroidsPrevalenceUnmasking symptomatic dermatographism in the time of COVID-19
Wong KH, Murray T, Osborn R, Soffer GK. Unmasking symptomatic dermatographism in the time of COVID-19. Postgraduate Medical Journal 2020, 97: 402-402. PMID: 32913035, PMCID: PMC10016992, DOI: 10.1136/postgradmedj-2020-138688.Peer-Reviewed Case Reports and Technical NotesNonpharmacologic therapeutic possibilities for immunosenescence
Soffer GK, Horwitz R, Weil A. Nonpharmacologic therapeutic possibilities for immunosenescence. Journal Of Allergy And Clinical Immunology 2020, 146: 922. PMID: 32718759, DOI: 10.1016/j.jaci.2020.06.021.Peer-Reviewed Original ResearchCommunity Private Practice Clinical Experience with Peanut Oral Immunotherapy
Afinogenova Y, Rubin T, Patel S, Powell R, Gilo J, Denno M, Soffer G, Lee J, Mendelson L, Factor J. Community Private Practice Clinical Experience with Peanut Oral Immunotherapy. The Journal Of Allergy And Clinical Immunology In Practice 2020, 8: 2727-2735. PMID: 32247684, DOI: 10.1016/j.jaip.2020.03.016.Peer-Reviewed Original ResearchConceptsPeanut oral immunotherapyPeanut-specific IgE levelsCutaneous adverse eventsRespiratory adverse eventsGastrointestinal adverse eventsAdverse eventsSpecific IgE levelsPeanut-allergic patientsOral immunotherapySystemic reactionsIgE levelsAdverse reactionsRetrospective chart reviewSpecific patient characteristicsMaintenance phaseAllergic profileGastrointestinal symptomsChart reviewImmunologic factorsPatient characteristicsPatient demographicsBlood pressureEosinophilic esophagitisAllergy testingPeanut allergy
2017
Allogeneic hematopoietic stem cell transplantation is associated with cure and durable remission of late‐onset primary isolated central nervous system hemophagocytic lymphohistiocytosis
Khazal S, Polishchuk V, Soffer G, Prinzing S, Gill J, Mahadeo KM. Allogeneic hematopoietic stem cell transplantation is associated with cure and durable remission of late‐onset primary isolated central nervous system hemophagocytic lymphohistiocytosis. Pediatric Transplantation 2017, 22 PMID: 29239076, DOI: 10.1111/petr.13101.Peer-Reviewed Original ResearchConceptsCNS-HLHDurable remissionsReduced-intensity conditioning regimenHematopoietic stem cell transplantationActive CNS diseaseLate-onset primaryStem cell transplantationAllogeneic HSCTCNS presentationsComorbidity indexConditioning regimenDisease remissionPrompt treatmentHemophagocytic lymphohistiocytosisSignificant morbidityPoor outcomeCell transplantationCNS diseaseAdolescent patientsPRF1 mutationsEarly diagnosisHigh indexRare diseaseRemissionImproved cureSuccessful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol
Soffer G, Cohen B, Toh J, Edelman D, Garg K, Jariwala S. Successful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol. Vascular And Endovascular Surgery 2017, 52: 59-60. PMID: 29084492, DOI: 10.1177/1538574417736420.Peer-Reviewed Original ResearchConceptsDose challengeRadiocontrast media (RCM) hypersensitivityPostanesthesia care unitHospital coursePrednisone taperCare unitFinal doseSafe procedureAdverse reactionsLower extremitiesRight toeRadiocontrast mediaRadiographic studiesPatientsOperating roomAngiogramsLiterature reviewHoursRevascularizationGangreneAnaphylaxisHospitalDiphenhydramineExtremitiesHypersensitivity
2016
A case of chronic contact dermatitis resulting from the use of blue hair dye
Soffer GK, Toh J, Clements S, Jariwala S. A case of chronic contact dermatitis resulting from the use of blue hair dye. Contact Dermatitis 2016, 75: 258-259. PMID: 27620129, DOI: 10.1111/cod.12628.Peer-Reviewed Original Research