Allogeneic hematopoietic stem cell transplantation is associated with cure and durable remission of late‐onset primary isolated central nervous system hemophagocytic lymphohistiocytosis
Khazal S, Polishchuk V, Soffer G, Prinzing S, Gill J, Mahadeo KM. Allogeneic hematopoietic stem cell transplantation is associated with cure and durable remission of late‐onset primary isolated central nervous system hemophagocytic lymphohistiocytosis. Pediatric Transplantation 2017, 22 PMID: 29239076, DOI: 10.1111/petr.13101.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCentral Nervous System DiseasesHematopoietic Stem Cell TransplantationHumansLymphohistiocytosis, HemophagocyticMaleTransplantation ConditioningTransplantation, HomologousConceptsCNS-HLHDurable remissionsReduced-intensity conditioning regimenHematopoietic stem cell transplantationActive CNS diseaseLate-onset primaryStem cell transplantationAllogeneic HSCTCNS presentationsComorbidity indexConditioning regimenDisease remissionPrompt treatmentHemophagocytic lymphohistiocytosisSignificant morbidityPoor outcomeCell transplantationCNS diseaseAdolescent patientsPRF1 mutationsEarly diagnosisHigh indexRare diseaseRemissionImproved cure