1987
The Vacuolar ATPase Is Responsible for Acidifying Secretory Organelles
RUDNICK G. The Vacuolar ATPase Is Responsible for Acidifying Secretory Organelles. Annals Of The New York Academy Of Sciences 1987, 493: 259-263. PMID: 2884921, DOI: 10.1111/j.1749-6632.1987.tb27206.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSimilarities and Differences among Neuroendocrine, Exocrine, and Endocytic Vesiclesa
CASTLE J, CAMERON R, ARVAN P, VON ZASTROW M, RUDNICK G. Similarities and Differences among Neuroendocrine, Exocrine, and Endocytic Vesiclesa. Annals Of The New York Academy Of Sciences 1987, 493: 448-460. PMID: 3296913, DOI: 10.1111/j.1749-6632.1987.tb27230.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsChromaffin GranulesCytoplasmic GranulesEndocrine GlandsExocrine GlandsIntracellular MembranesNeurosecretory SystemsConceptsPolarized epithelial cellsSpecific cellular compartmentsEndocytic systemCellular compartmentsEndocytic vesiclesPlasmalemmal domainsTranslocase activityGolgi complexSecretory systemAnalogous functionsCell surfaceDetermines functionCyclic carriersEpithelial cellsEndocrine sourceCompositional overlapMembrane preparationsExport trafficMembraneEndocrine secretionStructural elementsVesiclesComparative analysisParticular originSorting
1985
Relative lack of ATP-driven H+ translocase activity in isolated parotid secretory granules.
Arvan P, Rudnick G, Castle J. Relative lack of ATP-driven H+ translocase activity in isolated parotid secretory granules. Journal Of Biological Chemistry 1985, 260: 14945-14952. PMID: 2866180, DOI: 10.1016/s0021-9258(18)95684-x.Peer-Reviewed Original ResearchAcetatesAcetic AcidAdenosine TriphosphateAnimalsCarbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCell Membrane PermeabilityCytoplasmic GranulesEthylmaleimideHydrogen-Ion ConcentrationHydrolysisMembrane PotentialsMethylaminesParotid GlandProton-Translocating ATPasesRatsSodium CyanideSerotonin Transport by Platelet Plasma and Granule Membranes
RUDNICK G, HUMPHREYS C, DEAN G. Serotonin Transport by Platelet Plasma and Granule Membranes. Annals Of The New York Academy Of Sciences 1985, 456: 277-278. PMID: 2418730, DOI: 10.1111/j.1749-6632.1985.tb14876.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1984
Osmotic properties and internal pH of isolated rat parotid secretory granules.
Arvan P, Rudnick G, Castle J. Osmotic properties and internal pH of isolated rat parotid secretory granules. Journal Of Biological Chemistry 1984, 259: 13567-13572. PMID: 6490664, DOI: 10.1016/s0021-9258(18)90730-1.Peer-Reviewed Original ResearchThe hydrogen ion-pumping adenosine triphosphatase of platelet dense granule membrane. Differences from F1F0- and phosphoenzyme-type ATPases.
Dean G, Fishkes H, Nelson P, Rudnick G. The hydrogen ion-pumping adenosine triphosphatase of platelet dense granule membrane. Differences from F1F0- and phosphoenzyme-type ATPases. Journal Of Biological Chemistry 1984, 259: 9569-9574. PMID: 6204985, DOI: 10.1016/s0021-9258(17)42738-4.Peer-Reviewed Original ResearchConceptsGranule ATPaseGranule membranesMitochondrial membraneATP hydrolysisIon-translocating ATPasesEnergy-transducing membranesDense granule membraneIdentical assay conditionsF1F0-ATPasesSubstrate specificityPlasma membraneMitochondrial ATPaseInhibitor sensitivityATPasesATPaseATPase activityConcentrations of NaN3Cation requirementATPase moleculesMembraneN-ethylmaleimideAssay conditionsAdenosine triphosphataseEfrapeptinOligomycinSpiperone: evidence for uptake into secretory granules.
Dannies P, Rudnick M, Fishkes H, Rudnick G. Spiperone: evidence for uptake into secretory granules. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1867-1870. PMID: 6584920, PMCID: PMC345023, DOI: 10.1073/pnas.81.6.1867.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportButyrophenonesCells, CulturedCytoplasmic GranulesKineticsPituitary GlandRatsSpiperoneConceptsSerotonin receptorsSecretory granulesRat pituitary tumor cellsMicroM reserpinePlatelet dense granulesPituitary tumor cellsDopamine antagonistsIntracellular storage organellesSpiperoneTumor cellsSerotonin transportDense granulesBiogenic amine transportReceptorsCell strainsDopamineEquimolar concentrationsSpecific ligandsAmine transportStorage organellesPlasma membrane transport systemsReserpineAntagonistMinNeurons
1983
Acidification of macrophage and fibroblast endocytic vesicles in vitro.
Galloway C, Dean G, Marsh M, Rudnick G, Mellman I. Acidification of macrophage and fibroblast endocytic vesicles in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 3334-3338. PMID: 6190176, PMCID: PMC394037, DOI: 10.1073/pnas.80.11.3334.Peer-Reviewed Original ResearchConceptsAcidic prelysosomal compartmentEndosome-lysosome fusionATP-dependent acidificationF0-ATPaseEndocytic vesiclesPrelysosomal compartmentAddition of ATPPrelysosomal vacuolesMitochondrial F1LysosomesEndosomesSecretory granulesCultured macrophagesN-ethylmaleimideInternal pHPercoll density gradientsAcidificationPH gradientFibroblastsCompartmentsOrganellesInhibitorsPermeant anionsFluorescein-dextranVacuoles
1982
Bioenergetics of serotonin transport by membrane vesicles derived from platelet dense granules.
Fishkes H, Rudnick G. Bioenergetics of serotonin transport by membrane vesicles derived from platelet dense granules. Journal Of Biological Chemistry 1982, 257: 5671-5677. PMID: 7068613, DOI: 10.1016/s0021-9258(19)83830-9.Peer-Reviewed Original ResearchConceptsPlatelet dense granulesMembrane vesiclesSerotonin transport activitySoluble enzymatic activityPresence of ATPCarbonyl cyanide p-trifluoromethoxyphenylhydrazoneAddition of ATPOsmotic lysatesTransport activityCyanide p-trifluoromethoxyphenylhydrazoneEnzymatic activityDensity gradient centrifugationVesiclesSerotonin transportVesicle interiorDense granulesMembrane potentialP-trifluoromethoxyphenylhydrazoneGradient centrifugationATPAssay mediumAdenine nucleotidesBioenergeticsNucleotidesGranules
1981
Inhibition of platelet serotonin transport by propranolol.
Rudnick G, Bencuya R, Nelson P, Zito R. Inhibition of platelet serotonin transport by propranolol. Molecular Pharmacology 1981, 20: 118-23. PMID: 7290078.Peer-Reviewed Original Research