2014
Renalase Prevents AKI Independent of Amine Oxidase Activity
Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV. Renalase Prevents AKI Independent of Amine Oxidase Activity. Journal Of The American Society Of Nephrology 2014, 25: 1226-1235. PMID: 24511138, PMCID: PMC4033373, DOI: 10.1681/asn.2013060665.Peer-Reviewed Original ResearchConceptsIschemic injuryCatecholamine levelsRecombinant renalaseAmine oxidase activityHuman proximal tubular cellsCisplatin-induced AKITreatment of AKIWild-type miceHK-2 cellsProximal tubular cellsOxidase activityKidney injuryRenal injuryC-Jun N-terminal kinaseExtracellular signal-regulated kinaseP38 mitogen-activated protein kinaseToxic injuryRenalase proteinTubular cellsSignal-regulated kinaseIntracellular signaling cascadesRenalaseInjuryMitogen-activated protein kinaseN-terminal kinase
2002
Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.
Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. Journal Of The American Society Of Nephrology 2002, 13: 2831-9. PMID: 12444201, DOI: 10.1097/01.asn.0000036866.37886.c5.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsProximal tubular cellsSmooth muscle cellsApical membraneImportant cellular functionsSitu hybridization experimentsVascular toneVoltage-activated K channelsTubular cellsMuscle cellsImmunocytochemical studyCellular functionsHuman proximal tubular cellsRat proximal tubular cellsSubcellular localizationHybridization experimentsVoltage-gated K channelsK channelsNorthern blotRenal proximal tubulesCell membrane voltageVascular endothelial cellsKCNA10Cell membrane potentialVascular tissue
1991
Reconstitution and partial purification of an amiloride-sensitive, cation channel from rabbit kidney
Desir G. Reconstitution and partial purification of an amiloride-sensitive, cation channel from rabbit kidney. Biochimica Et Biophysica Acta 1991, 1067: 38-42. PMID: 1868102, DOI: 10.1016/0005-2736(91)90023-2.Peer-Reviewed Original ResearchMeSH KeywordsAcridine OrangeAmilorideAnimalsBasement MembraneCell MembraneDithiazanineKidney Tubules, ProximalMaleMembrane ProteinsPotassium ChannelsProteolipidsRabbitsConceptsBrush border membrane vesiclesCation channelsMembrane vesicle proteinsChannel activityAmiloride-sensitive cation channelVesicle proteinsBorder membrane vesiclesMembrane vesiclesRabbit brush border membrane vesiclesProteoliposomesNative brush border membranesBrush border membraneSensitive cation channelPotassium channelsProteinPartial purificationAcridine orangeRenal brush-border membrane vesiclesBorder membraneDiethylthiadicarbocyanine iodideReconstitutionRabbit kidney