2022
Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation
Guo X, Xu L, Velazquez H, Chen TM, Williams RM, Heller DA, Burtness B, Safirstein R, Desir GV. Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation. Journal Of The American Society Of Nephrology 2022, 33: 342-356. PMID: 34921111, PMCID: PMC8819981, DOI: 10.1681/asn.2021040439.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntineoplastic AgentsCell LineCisplatinCreatinineDisease Models, AnimalGene ExpressionGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidneyMiceMice, Inbred C57BLMice, KnockoutMonoamine OxidaseNanocapsulesPeptidesRenal Insufficiency, ChronicConceptsRenal proximal tubulesSingle-cell RNA sequencing analysisMesoscale nanoparticlesFirst doseCisplatin chemotherapyProximal tubulesAgonist peptideInduced Chronic Kidney DiseaseGenetic deletionNeck squamous cell carcinomaRNA sequencing analysisCisplatin-induced AKIKidney-targeted deliveryChronic kidney diseaseDevelopment of CKDSquamous cell carcinomaAdministration of cisplatinPlasma renalaseAdvanced headCell carcinomaInflammatory cytokinesKidney diseasePlasma creatinineSystemic administrationRegulated necrosis
2013
Renalase Protects against Ischemic AKI
Lee HT, Kim JY, Kim M, Wang P, Tang L, Baroni S, D’Agati V, Desir GV. Renalase Protects against Ischemic AKI. Journal Of The American Society Of Nephrology 2013, 24: 445-455. PMID: 23393318, PMCID: PMC3582209, DOI: 10.1681/asn.2012090943.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdrenergic alpha-AntagonistsAnimalsApoptosisGene ExpressionHumansInflammation MediatorsIschemiaKidney Tubular Necrosis, AcuteMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMonoamine OxidaseNeutrophil InfiltrationNorepinephrinePhentolamineRecombinant ProteinsReperfusion InjuryRNA, MessengerConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryIschemic AKIWild-type miceReperfusion injuryCatecholamine levelsRenal tubular inflammationTreatment of AKIRenal ischemia reperfusionSham-operated micePlasma catecholamine levelsRenal tubular necrosisRecombinant human renalasePlasma renalaseTubular inflammationTubular necrosisIschemia reperfusionNE levelsPlasma catecholaminesMyocardial necrosisInflammatory responseProximal tubulesAKIRenalaseMice
1998
Rabbit distal convoluted tubule coexpresses NaCl cotransporter and 11β-hydroxysteroid dehydrogenase II mRNA
Velázquez H, Náray-Fejes-Tóth A, Silva T, Andújar E, Reilly RF, Desir GV, Ellison DH. Rabbit distal convoluted tubule coexpresses NaCl cotransporter and 11β-hydroxysteroid dehydrogenase II mRNA. Kidney International 1998, 54: 464-472. PMID: 9690213, DOI: 10.1046/j.1523-1755.1998.00036.x.Peer-Reviewed Original ResearchConceptsProximal tubulesNaCl cotransporterNephron segmentsDissected nephron segmentsTarget tissuesAction of aldosteroneAldosterone target tissuesSame nephron segmentsPolymerase chain reaction techniqueReverse transcriptase/polymerase chain reaction techniqueChain reaction techniqueDietary NaClDistal nephronBeta-HSDCCD samplesMRNA expressionNaCl cotransportRecent evidenceSimilar extentAldosteroneCotransporterHigh ratePrincipal targetTubulesTissue
1997
Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments
Orias M, Velázquez H, Tung F, Lee G, Desir G. Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. American Journal Of Physiology 1997, 273: f663-f666. PMID: 9362344, DOI: 10.1152/ajprenal.1997.273.4.f663.Peer-Reviewed Original ResearchConceptsThick ascending limbAscending limbK channelsCortical thick ascending limbMedullary thick ascending limbDistal nephron segmentsReverse transcription-polymerase chain reactionDistal convoluted tubuleTranscription-polymerase chain reactionDistal tubulesConvoluted tubulesProximal tubulesNephron segmentsHigh expressionNephron segment localizationK homeostasisChain reactionHuman kidney cDNATubulesSegment localizationExclusive expressionKCNK1LimbPore regionKidney cDNA
1993
Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex
Ellison DH, Biemesderfer D, Morrisey J, Lauring J, Desir GV. Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex. American Journal Of Physiology 1993, 264: f141-f148. PMID: 8430824, DOI: 10.1152/ajprenal.1993.264.1.f141.Peer-Reviewed Original ResearchConceptsThiazide diuretic receptorRenal distal tubulesDistal tubulesUrinary NaCl excretionRenal cortical membranesThick ascending limbRabbit kidney cortexApical membraneThiazide diureticsRenal cortexRabbit renal cortexCortical membranesProximal tubulesAscending limbSubpopulation of cellsNaCl excretionThiazide receptorKidney cortexIntense stainingWestern blotMonoclonal antibodiesRabbit kidneyImmunocytochemical characterizationPrincipal cellsReceptors