2017
Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension
Pescatello LS, Schifano ED, Ash GI, Panza GA, Corso LML, Chen M, Deshpande V, Zaleski A, Cilhoroz B, Farinatti P, Taylor BA, O'Neill RJ, Thompson PD. Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension. Physiological Reports 2017, 5: e13510. PMID: 29180482, PMCID: PMC5704084, DOI: 10.14814/phy2.13510.Peer-Reviewed Original ResearchConceptsPost-exercise hypotensionAmbulatory blood pressure responsesBlood pressure responseAmbulatory BP monitorObese African AmericansModerate-intensity exerciseModerate-intensity cyclingMultiple testing thresholdDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityVariant genotypesIntensity cyclingMmHgTesting thresholdMinor alleleModerate intensityPressure responseHypotensionHypertensionAfrican AmericansThe antihypertensive effects of aerobic versus isometric handgrip resistance exercise
Ash GI, Taylor BA, Thompson PD, MacDonald HV, Lamberti L, Chen MH, Farinatti P, Kraemer WJ, Panza GA, Zaleski AL, Deshpande V, Ballard KD, Mujtaba M, White CM, Pescatello LS. The antihypertensive effects of aerobic versus isometric handgrip resistance exercise. Journal Of Hypertension 2017, 35: 291-299. PMID: 27861249, PMCID: PMC5713890, DOI: 10.1097/hjh.0000000000001176.Peer-Reviewed Original ResearchConceptsIHG trainingAntihypertensive effectBlood pressureAerobic exerciseResistance exerciseCarotid-femoral pulse wave velocityPulse wave velocity changesBP benefitPrimary exercise modalityAmbulatory BP monitorPulse wave velocityMiddle-aged adultsSubset of participantsAntihypertensive therapyAwake SBPIHG exerciseAcute exerciseExercise modalitiesAcute boutAerobic trainingBP monitorAwake hoursStudy participantsLimited evidenceSBP
2016
Deep‐targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans
Pescatello LS, Schifano ED, Ash GI, Panza GA, Lamberti L, Chen M, Deshpande V, Zaleski A, Farinatti P, Taylor BA, Thompson PD. Deep‐targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans. Physiological Reports 2016, 4: e12992. PMID: 27940662, PMCID: PMC5064144, DOI: 10.14814/phy2.12992.Peer-Reviewed Original ResearchConceptsMultiple testing thresholdADD1 variantsAngiotensin type 1 receptorAmbulatory blood pressure responsesTesting thresholdBlood pressure responseExon sequencingAmbulatory BP monitorModerate-intensity exerciseType 1 receptorModerate-intensity cyclingPostexercise hypotensionRenal variantDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityAdducin geneVariant genotypesAldosterone synthaseIntensity cyclingCYP11B2 variants
2015
The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies
Bruneau ML, Johnson BT, Huedo-Medina TB, Larson KA, Ash GI, Pescatello LS. The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies. Journal Of Science And Medicine In Sport 2015, 19: 424-431. PMID: 26122461, DOI: 10.1016/j.jsams.2015.05.009.Peer-Reviewed Original ResearchConceptsAngiotensinogen M235TChronic aerobic exerciseDiastolic blood pressureBlood pressure changesBlood pressurePost-exercise phaseAerobic exerciseM235TAmbulatory conditionsCandidate gene association studiesBlood pressure responseAerobic exercise interventionAerobic exercise trainingGene association studiesChanges of BPMaximum oxygen consumptionOnly genetic variantExercise interventionOverweight menExercise trainingAcute exercisePressure changesSample characteristicsSystematic searchAssociation studies