2024
Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention
Callegari S, Romain G, Cleman J, Scierka L, Jacque F, Smolderen K, Mena‐Hurtado C. Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention. Journal Of The American Heart Association 2024, 13: e034477. PMID: 38761075, PMCID: PMC11179837, DOI: 10.1161/jaha.124.034477.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaPeripheral vascular interventionsHealth careLimb-threatening ischemiaMortality predictorsLong-term mortality riskMultidimensional risk factorsBody mass indexLong-term mortality predictorsImprove individualized careVascular interventionsIndividualized careAssisted careBiopsychosocial modelMortality riskCareMass indexRisk factorsMedical comorbiditiesRisk profileInterventionMortality rateChronic kidney diseaseMortalityPredictive variablesInter-Rater Reliability for the Amputation Endpoint in the National Vascular Quality Initiative
Smolderen K, Romain G, Scierka L, Cleman J, Rahman M, Siddiqui W, Lau F, Mao J, Akhlaghi N, Higaki A, Fowler X, Carroll M, Telma K, Alvermann T, Baribeau V, Goodney P, Mena-Hurtado C. Inter-Rater Reliability for the Amputation Endpoint in the National Vascular Quality Initiative. JACC Cardiovascular Interventions 2024, 17: 622-631. PMID: 38479964, DOI: 10.1016/j.jcin.2024.01.003.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record reviewAmputation dataPeripheral arterial diseaseInterrater reliabilityVQI registryAcademic health systemTrained data collectorsNational quality registryInter-rater reliabilityEvaluate interrater reliabilityNational reporting systemHealth recordsQuality registryHealth systemCurrent Procedural Terminology codesInter-raterVascular Quality Initiative registryVascular Quality InitiativeProcedural Terminology codesNational Vascular Quality InitiativeRegistryQuality InitiativeAmputationSpearman's r
2023
Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress ScaleRepresentativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines
Castro-Dominguez Y, Mena-Hurtado C, Algara M, Obas V, Ahmed Z, Romain G, Solaru K, Smolderen K. Representativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines. The American Journal Of Cardiology 2023, 201: 166-169. PMID: 37385170, DOI: 10.1016/j.amjcard.2023.05.053.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD guidelinesArtery diseaseRecent American Heart Association/American CollegeAmerican Heart Association/American CollegeLower extremity peripheral artery diseaseOlder adult patientsRace/ethnicity distributionAdult patientsPooled proportionMean ageClinical trialsCurrent guidelinesEpidemiologic studiesAmerican CollegeTrial participantsRCTsEthnicity distributionOlder adultsTrialsWomenPatientsDiseaseGuidelinesEthnic groupsComparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative
Cleman J, Romain G, Grubman S, Guzman R, Smolderen K, Mena-Hurtado C. Comparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative. Journal Of Vascular Surgery 2023, 78: 745-753.e6. PMID: 37207790, PMCID: PMC10964324, DOI: 10.1016/j.jvs.2023.05.015.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaLower extremity bypassPeripheral vascular interventionsVascular Quality InitiativeLimb-threatening ischemiaCause mortalityRisk of deathExtremity bypassVascular interventionsQuality InitiativeCox proportional hazards regressionKaplan-Meier survival curvesProportional hazards regressionOverall mean ageLogistic regression modelsComparative effectiveness researchKnee poplitealMedicare registryInfrapopliteal arteriesHazards regressionMean ageThirty-dayHispanic ethnicityOutcome dataTreatment groupsDrug‐Coated Balloon and Drug‐Eluting Stent Safety in Patients With Femoropopliteal and Severe Chronic Kidney Disease
Hanna J, Smolderen K, Castro‐Dominguez Y, Romain G, Lee M, Turner J, Mena‐Hurtado C. Drug‐Coated Balloon and Drug‐Eluting Stent Safety in Patients With Femoropopliteal and Severe Chronic Kidney Disease. Journal Of The American Heart Association 2023, 12: e028622. PMID: 36974774, PMCID: PMC10122876, DOI: 10.1161/jaha.122.028622.Peer-Reviewed Original ResearchConceptsEarly-stage chronic kidney diseaseChronic kidney diseaseBare metal stentsDrug-eluting stentsDrug-coated balloonsMortality riskAmputation riskKidney diseaseSevere chronic kidney diseaseMajor amputation riskPlain balloon angioplastyDrug-Coated BalloonAmputation outcomesCKD statusAmputation rateCause mortalityBackground PatientsAdjusted analysisBalloon angioplastyFemoropopliteal interventionsDES useBMS useRegistry dataDisease trialsPatientsCommunity distress and risk of adverse outcomes after peripheral vascular intervention
Schenck C, Strand E, Smolderen K, Romain G, Nagpal S, Cleman J, Blume P, Mena-Hurtado C. Community distress and risk of adverse outcomes after peripheral vascular intervention. Journal Of Vascular Surgery 2023, 78: 166-174.e3. PMID: 36944389, PMCID: PMC11146282, DOI: 10.1016/j.jvs.2023.03.027.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsDistressed Communities IndexMajor amputationRisk of mortalityAdverse outcomesVascular interventionsVascular Quality Initiative databaseDCI scoresCommunity distressCox regression modelTime-dependent receiverCharacteristic curve analysisClinical characteristicsFinal cohortPrimary outcomeClinical outcomesCardiovascular diseasePatientsAmputationZip code dataMortalityRisk categoriesCurve analysisInitiative databaseOutcomesLower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participantsGuideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions
Smolderen K, Romain G, Provance J, Scierka L, Mao J, Goodney P, Henke P, Sedrakyan A, Mena-Hurtado C. Guideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions. JACC Cardiovascular Interventions 2023, 16: 332-343. PMID: 36792257, PMCID: PMC10359106, DOI: 10.1016/j.jcin.2022.09.022.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyPeripheral vascular interventionsMedical therapyVascular interventionsEnzyme inhibitors/angiotensin receptor blockersVascular Quality Initiative registryAngiotensin receptor blockersLong-term mortalityRisk of amputationRisk of mortalityNational quality registryQuality improvement effortsAmputation outcomesAmputation riskMajor amputationAntiplatelet therapyCause mortalityReceptor blockersMean ageVascular careQuality registryObservational studyMortality riskHigh riskAmputation data
2022
Patient-level and external factors in the use of drug-coated balloons and drug-eluting stents in femoropopliteal endovascular interventions
Castro-Dominguez Y, Smolderen KG, Pichert M, Alabi O, Romain G, Huang J, Lee M, Ahmed Z, Peri-Okonny PA, Arham A, Brice A, Chaar CO, Stacy MR, Mena-Hurtado C. Patient-level and external factors in the use of drug-coated balloons and drug-eluting stents in femoropopliteal endovascular interventions. Journal Of Vascular Surgery 2022, 76: 1675-1680. PMID: 35868423, DOI: 10.1016/j.jvs.2022.06.093.Peer-Reviewed Original ResearchConceptsDrug-coated balloonsDrug-eluting stentsBare metal stentsDES useFemoropopliteal endovascular interventionEndovascular interventionMedian odds ratioFemoropopliteal diseaseLesion characteristicsPrimary treatmentChronic kidney disease stage 4Adjusted median odds ratioVascular Quality Initiative registryAppropriate use guidelinesPrior anticoagulant usePatient-level factorsPoor functional statusTrans-Atlantic InterPlain balloon angioplastyPatient-level characteristicsFavorable patency ratesHierarchical logistic regression modelsLogistic regression modelsMeta-analysis publicationsRutherford classification
2021
Outcomes of anus squamous cell carcinoma. Management of anus squamous cell carcinoma and recurrences
Marref I, Romain G, Jooste V, Vendrely V, Lopez A, Faivre J, Gerard J, Bouvier A, Lepage C. Outcomes of anus squamous cell carcinoma. Management of anus squamous cell carcinoma and recurrences. Digestive And Liver Disease 2021, 53: 1492-1498. PMID: 34193366, DOI: 10.1016/j.dld.2021.05.028.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCell carcinomaAnal canalNet survivalBurgundy Digestive Cancer RegistryFive-year net survivalDigestive cancer registryCumulative recurrence ratePersistent active diseaseRisk of deathMultivariate survival analysisCumulative incidence functionCurative intentActive diseaseAbdominoperineal resectionAggressive managementCancer RegistryLocal inflammationRecurrence rateChemoradiotherapyCarcinomaRecurrenceRoutine practiceSurvival analysisRadiotherapy
2020
Cancer cure for 32 cancer types: results from the EUROCARE-5 study
Dal Maso L, Panato C, Tavilla A, Guzzinati S, Serraino D, Mallone S, Botta L, Boussari O, Capocaccia R, Colonna M, Crocetti E, Dumas A, Dyba T, Franceschi S, Gatta G, Gigli A, Giusti F, Jooste V, Minicozzi P, Neamtiu L, Romain G, Zorzi M, De Angelis R, Francisci S, Group T. Cancer cure for 32 cancer types: results from the EUROCARE-5 study. International Journal Of Epidemiology 2020, 49: 1517-1525. PMID: 32984907, DOI: 10.1093/ije/dyaa128.Peer-Reviewed Original ResearchConceptsConditional relative survivalCancer patientsProstate cancerCancer cureChronic lymphocytic leukemia patientsProportion of patientsThyroid cancer patientsEUROCARE-5 studyLymphocytic leukemia patientsSame death ratePopulation-based indicatorsMelanoma patientsPatients' qualityCorpus uteriFatal casesLung cancerPancreatic cancerThyroid cancerLeukemia patientsBreast cancerGeneral populationRelative survivalPatientsSkin melanomaAge 55
2019
Long-Term Relative Survival after Stroke: The Dijon Stroke Registry
Romain G, Mariet A, Jooste V, Duloquin G, Thomas Q, Durier J, Giroud M, Quantin C, Béjot Y. Long-Term Relative Survival after Stroke: The Dijon Stroke Registry. Neuroepidemiology 2019, 54: 498-505. PMID: 31865347, DOI: 10.1159/000505160.Peer-Reviewed Original ResearchConceptsDijon Stroke RegistryOlder age groupsStroke subtypesStroke RegistryIschemic strokeIntracerebral hemorrhagePopulation-based Dijon Stroke RegistryAge groupsStroke-related deathLong-term outcomesSurvival profilesExcess mortality ratesLong-term survivalRelative survival methodsSex differencesUndetermined strokeCause mortalityOlder patientsYounger patientsStroke cohortICH patientsIS patientsAdjusted survivalObserved survivalGeneral populationNet survival in recurrence-free colon cancer patients
Drouillard A, Bouvier A, Boussari O, Romain G, Manfredi S, Lepage C, Faivre J, Jooste V. Net survival in recurrence-free colon cancer patients. Cancer Epidemiology 2019, 61: 124-128. PMID: 31212224, DOI: 10.1016/j.canep.2019.06.001.Peer-Reviewed Original ResearchConceptsRecurrence-free patientsNet survivalColon cancerPopulation-based digestive cancer registryConditional net survivalDigestive cancer registryStage III diseasePeriods of remissionEstimation of prognosisPrimary colon cancerColon cancer patientsRelevant clinical informationCancer RegistryClinical presentationCancer patientsCancer populationSurvivors' qualityClinical informationPatientsStage IStage IIIStage IIDiagnosisFlexible parametric modelsSurvivalImpact of absence of consensual cutoff time distinguishing between synchronous and metachronous metastases: illustration with colorectal cancer
Willem H, Jooste V, Boussari O, Romain G, Bouvier A. Impact of absence of consensual cutoff time distinguishing between synchronous and metachronous metastases: illustration with colorectal cancer. European Journal Of Cancer Prevention 2019, 28: 167-172. PMID: 29738323, DOI: 10.1097/cej.0000000000000450.Peer-Reviewed Original ResearchConceptsColorectal cancerMetachronous metastasesMetachronous groupNet survivalStage IV colorectal cancerStage IV patientsAge-standardized incidenceDiagnosis of metastasisProportion of cancersSynchronous groupSynchronous metastasesIV patientsCancer RegistryPrimary diagnosisColorectal adenocarcinomaEpidemiological studiesStage IIIStage IVRelevant cutoffsMetastasisStage IICancerFirst monthMonthsIncidenceTime-to-cure and cure proportion in solid cancers in France. A population based study
Romain G, Boussari O, Bossard N, Remontet L, Bouvier A, Mounier M, Iwaz J, Colonna M, Jooste V, Registries F. Time-to-cure and cure proportion in solid cancers in France. A population based study. Cancer Epidemiology 2019, 60: 93-101. PMID: 30933890, DOI: 10.1016/j.canep.2019.02.006.Peer-Reviewed Original ResearchConceptsTestis cancerCancer sitesThyroid cancerCure proportionFrench cancer registriesMost cancer sitesLarge national databaseHealthcare policy makersGynaecologic cancerYounger patientsCancer RegistryColorectal cancerSurvival cure modelUrinary tractCancer careDigestive cancersSolid cancersSkin melanomaSolid tumorsSmall intestineCancerPatientsNational databaseBreastCure
2018
Time trends and short term projections of cancer prevalence in France
Colonna M, Boussari O, Cowppli-Bony A, Delafosse P, Romain G, Grosclaude P, Jooste V, Registries F. Time trends and short term projections of cancer prevalence in France. Cancer Epidemiology 2018, 56: 97-105. PMID: 30125884, DOI: 10.1016/j.canep.2018.08.001.Peer-Reviewed Original ResearchA new approach to estimate time-to-cure from cancer registries data
Boussari O, Romain G, Remontet L, Bossard N, Mounier M, Bouvier A, Binquet C, Colonna M, Jooste V. A new approach to estimate time-to-cure from cancer registries data. Cancer Epidemiology 2018, 53: 72-80. PMID: 29414635, DOI: 10.1016/j.canep.2018.01.013.Peer-Reviewed Original ResearchConceptsPopulation-based cancer dataFlexible parametric cure modelsThyroid cancer patientsCancer registry dataParametric cure modelsCancer RegistryColorectal cancerCancer patientsPancreatic cancerCancer sitesBreast cancerRegistry dataCure modelAge groupsCancerCureDiagnosisSurvival frameworkCure fractionPatientsHealth insurance premiumsFrench networkSurvival time distributionYears
2017
Outcomes following polypectomy for malignant colorectal polyps are similar to those following surgery in the general population
Lopez A, Bouvier A, Jooste V, Cottet V, Romain G, Faivre J, Manfredi S, Lepage C. Outcomes following polypectomy for malignant colorectal polyps are similar to those following surgery in the general population. Gut 2017, 68: 111. PMID: 29074726, DOI: 10.1136/gutjnl-2016-312093.Peer-Reviewed Original ResearchConceptsSessile malignant polypsColorectal malignant polypsMalignant polypsPathological marginsEndoscopic resectionSurgical resectionRecurrence rateGeneral populationAge-standardised incidence ratesFive-year net survivalAge-standardised incidenceCumulative recurrence ratePopulation-based studyMalignant colorectal polypsTransanal resectionIncidence rateResectionColorectal polypsNet survivalPatientsSurvival analysisSurgeryPolypectomyTime trendsOutcomes