2021
Purposeful Fentanyl Use and Associated Factors among Opioid-Dependent People Who Inject Drugs
Chandra DK, Altice FL, Copenhaver MM, Zhou X, Didomizio E, Shrestha R. Purposeful Fentanyl Use and Associated Factors among Opioid-Dependent People Who Inject Drugs. Substance Use & Misuse 2021, 56: 979-987. PMID: 33769199, DOI: 10.1080/10826084.2021.1901931.Peer-Reviewed Original ResearchConceptsOpioid-dependent PWIDFentanyl useOpioid-dependent peopleIndependent correlatesSevere depressionSex-related risk behaviorsMethadone-maintained patientsMultivariable logistic regressionOpioid-related mortalityRecent cocaine useCross-sectional surveySelf-reported drugMethadone dosageYoung PWIDDaily injectionsMethadone clinicsAssociated FactorsFentanyl exposureHigh prevalencePWIDSynthetic opioidsCocaine useYounger ageRisk behaviorsLogistic regression
2020
Modeling Combination Hepatitis C Virus Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the United States
Zelenev A, Li J, Shea P, Hecht R, Altice FL. Modeling Combination Hepatitis C Virus Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the United States. Clinical Infectious Diseases 2020, 72: 755-763. PMID: 32060534, PMCID: PMC7935393, DOI: 10.1093/cid/ciaa142.Peer-Reviewed Original ResearchConceptsOpioid agonist therapySyringe services programHepatitis C virus (HCV) treatmentC virus treatmentHCV prevalenceHCV microeliminationHCV TasPHCV treatmentPrevention strategiesVirus treatmentTasP strategyHigh HCV prevalenceMicroelimination of HCVHuman immunodeficiency virusHCV treatment coverageOAT coverageAgonist therapyImmunodeficiency virusTreatment coverageMicroeliminationPrevention impactPrevalenceComplimentary interventionsHCVPWID
2018
Retention in HIV care during the 3 years following release from incarceration: A cohort study
Loeliger KB, Meyer JP, Desai MM, Ciarleglio MM, Gallagher C, Altice FL. Retention in HIV care during the 3 years following release from incarceration: A cohort study. PLOS Medicine 2018, 15: e1002667. PMID: 30300351, PMCID: PMC6177126, DOI: 10.1371/journal.pmed.1002667.Peer-Reviewed Original ResearchConceptsViral suppressionInjection drug useHIV careCohort studyTreatment outcomesDrug useNational HIV prevention strategyMultivariable logistic regression modelCase management visitsProportion of followRetrospective cohort studyEarly linkageHIV prevention strategiesLongitudinal treatment outcomesHealth insuranceBetter treatment outcomesSubstance use disordersCase management servicesLogistic regression modelsAntiretroviral therapyCohort participantsManagement visitsCriminal justice populationsLarge cohortPsychiatric disordersAll-cause mortality among people with HIV released from an integrated system of jails and prisons in Connecticut, USA, 2007–14: a retrospective observational cohort study
Loeliger KB, Altice FL, Ciarleglio MM, Rich KM, Chandra DK, Gallagher C, Desai MM, Meyer JP. All-cause mortality among people with HIV released from an integrated system of jails and prisons in Connecticut, USA, 2007–14: a retrospective observational cohort study. The Lancet HIV 2018, 5: e617-e628. PMID: 30197101, PMCID: PMC6279524, DOI: 10.1016/s2352-3018(18)30175-9.Peer-Reviewed Original ResearchConceptsIndex releaseCause mortalityMortality rateRetrospective observational cohort studyCox proportional hazards modelLow CD4 countObservational cohort studyHIV surveillance dataCrude mortality rateGeneral US populationProportional hazards modelStandardised mortality ratiosSubstance use disordersSystems of careHIV/AIDSSurvival of peopleVirological failureAntiretroviral therapyCD4 countMedical comorbiditiesCohort studyRetrospective cohortMedian ageLiver diseaseViral load
2017
Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users
Shrestha R, Karki P, Altice FL, Dubov O, Fraenkel L, Huedo-Medina T, Copenhaver M. Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users. AIDS And Behavior 2017, 22: 1228-1238. PMID: 28695388, PMCID: PMC5762432, DOI: 10.1007/s10461-017-1851-1.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisSex-related risk behaviorsHigh-risk drug usersAcceptability of PrEPHigh-risk PWUDPrimary HIV preventionHIV prevention approachesDrug treatment settingsKey risk populationsHIV-negative PWUDHigh acceptabilityHIV clinicPrEP acceptabilityHIV testingPrEP uptakeMethadone clinicsHIV preventionRisk populationsSide effectsTreatment settingsDrug usersPrEP attributesRisk behaviorsPrEPUnderserved populationsInnovative Program Delivery and Determinants of Frequent Visitation to a Mobile Medical Clinic in an Urban Setting
Gibson BA, Morano JP, Walton MR, Marcus R, Zelenev A, Bruce RD, Altice FL. Innovative Program Delivery and Determinants of Frequent Visitation to a Mobile Medical Clinic in an Urban Setting. Journal Of Health Care For The Poor And Underserved 2017, 28: 643-662. PMID: 28529215, DOI: 10.1353/hpu.2017.0065.Peer-Reviewed Original ResearchConceptsMobile medical clinicMedical clinicsInjection drug useVulnerable populationsHealth careHealth insurance coveragePatient characteristicsContinuous health careAcute careAffordable Care ActDrug useNegative binomial regressionInsurance coverageCare ActCareCertain populationsUtilization patternsBinomial regressionClinicVisitsProgram deliveryUnique clientsNew HavenPopulationSpecific indicators
2016
Examining the Acceptability of mHealth Technology in HIV Prevention Among High-Risk Drug Users in Treatment
Shrestha R, Huedo-Medina TB, Altice FL, Krishnan A, Copenhaver M. Examining the Acceptability of mHealth Technology in HIV Prevention Among High-Risk Drug Users in Treatment. AIDS And Behavior 2016, 21: 3100-3110. PMID: 28025735, PMCID: PMC5484759, DOI: 10.1007/s10461-016-1637-x.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultCell PhoneConnecticutDelivery of Health CareDrug UsersFemaleHIV InfectionsHumansInternetMaleMethadoneNeurocognitive DisordersOpiate Substitution TreatmentPatient Acceptance of Health CarePrevalenceRisk FactorsRisk-TakingSexual BehaviorSmartphoneSubstance Abuse, IntravenousTelemedicineText MessagingConceptsSex-related risk behaviorsNeurocognitive impairmentDrug usersRisk behaviorsHIV-negative drug usersHigh-risk drug usersHigh-risk populationHigh-risk peopleHIV prevention effortsUse of mHealthMethadone clinicsHIV preventionHigh prevalenceMedication remindersHealth programsMHealth acceptancePrevention effortsHealth conditionsMHealth technologiesConvenience sampleDrugsStandardized assessmentReal-world acceptanceMobile healthPhone calls
2015
Sex-Related Disparities in Criminal Justice and HIV Treatment Outcomes: A Retrospective Cohort Study of HIV-Infected Inmates.
Meyer JP, Cepeda J, Taxman FS, Altice FL. Sex-Related Disparities in Criminal Justice and HIV Treatment Outcomes: A Retrospective Cohort Study of HIV-Infected Inmates. American Journal Of Public Health 2015, 105: 1901-10. PMID: 26180958, PMCID: PMC4529767, DOI: 10.2105/ajph.2015.302687.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyViral suppressionSex-related differencesHigh prevalenceRisk scoreHIV treatment outcomesRetrospective cohort studyHIV viral suppressionLarge contemporary cohortSex-related disparitiesSex-specific interventionsCommunity-based treatmentWomen's higher prevalenceLogistic regression modelsCJ populationsTreatable comorbiditiesCohort studyHIV outcomesContemporary cohortTreatment outcomesHIVCJ involvementIncarceration durationOlder ageSignificant correlates
2014
Buprenorphine Maintenance Treatment Retention Improves Nationally Recommended Preventive Primary Care Screenings when Integrated into Urban Federally Qualified Health Centers
Haddad MS, Zelenev A, Altice FL. Buprenorphine Maintenance Treatment Retention Improves Nationally Recommended Preventive Primary Care Screenings when Integrated into Urban Federally Qualified Health Centers. Journal Of Urban Health 2014, 92: 193-213. PMID: 25550126, PMCID: PMC4338126, DOI: 10.1007/s11524-014-9924-1.Peer-Reviewed Original ResearchConceptsBuprenorphine maintenance therapyPrimary care providersPrimary health care settingsHealth care screeningQualified health centersHealth care settingsOpioid dependenceHealth centersPsychiatric specialistsUrban Federally Qualified Health CenterFederally Qualified Health CentersOpioid-dependent womenPrimary care screeningObservational cohort studyOpioid-dependent patientsHuman immunodeficiency virusProportion of subjectsHealth care indicatorsHealth care outcomesImproved health outcomesElectronic health recordsUrban FQHCsHepatitis CMaintenance therapyCohort studyEmergency Department Use among HIV-Infected Released Jail Detainees
Boyd AT, Song DL, Meyer JP, Altice FL. Emergency Department Use among HIV-Infected Released Jail Detainees. Journal Of Urban Health 2014, 92: 108-135. PMID: 25331820, PMCID: PMC4338130, DOI: 10.1007/s11524-014-9905-4.Peer-Reviewed Original ResearchConceptsHIV primary careEmergency department useED visitsPrimary careHIV careED useDepartment useDrug severitySubstance useCox proportional hazards regressionUnique ED visitsProportional hazards regressionMultivariate negative binomial regressionHIV/AIDSRecent substance useHealth care continuityPrimary outcomeHazards regressionCare continuityFemale sexMedical recordsJail detentionJail detaineesNegative binomial regressionPotential covariatesStrategies for Hepatitis C Testing and Linkage to Care for Vulnerable Populations: Point-of-Care and Standard HCV Testing in a Mobile Medical Clinic
Morano JP, Zelenev A, Lombard A, Marcus R, Gibson BA, Altice FL. Strategies for Hepatitis C Testing and Linkage to Care for Vulnerable Populations: Point-of-Care and Standard HCV Testing in a Mobile Medical Clinic. Journal Of Community Health 2014, 39: 922-934. PMID: 25135842, PMCID: PMC8317466, DOI: 10.1007/s10900-014-9932-9.Peer-Reviewed Original ResearchConceptsHCV testing strategyMobile medical clinicHCV testingHCV careHCV treatmentPatient preferencesPOC testingPrior injection drug useMedical clinicsHepatitis C testingReactive test resultsInjection drug useRoutine health assessmentsPrior STI diagnosisTesting strategiesHCV prevalenceStandard phlebotomySTI diagnosisTherapeutic advancesSpecialty clinicSerological testingWhite raceC testingDrug useHCVLatent tuberculosis infection screening in foreign-born populations: a successful mobile clinic outreach model.
Morano JP, Zelenev A, Walton MR, Bruce RD, Altice FL. Latent tuberculosis infection screening in foreign-born populations: a successful mobile clinic outreach model. American Journal Of Public Health 2014, 104: 1508-15. PMID: 24922157, PMCID: PMC4103248, DOI: 10.2105/ajph.2014.301897.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionTuberculin skin testTuberculosis infectionActive tuberculosisLTBI prevalenceSkin testRisk factorsScreening programHeroin useEligibility criteriaUnstable housingUninsured populationMedical surveyHealth insuranceMarijuana useOutreach modelInfectionRelevant correlatesInterpersonal violenceForeign-born populationNew HavenUrban settingsPopulationTuberculosisPrevalenceAccessibility and utilization patterns of a mobile medical clinic among vulnerable populations
Gibson BA, Ghosh D, Morano JP, Altice FL. Accessibility and utilization patterns of a mobile medical clinic among vulnerable populations. Health & Place 2014, 28: 153-166. PMID: 24853039, PMCID: PMC4475348, DOI: 10.1016/j.healthplace.2014.04.008.Peer-Reviewed Original ResearchOptimization of Human Immunodeficiency Virus Treatment During Incarceration: Viral Suppression at the Prison Gate
Meyer JP, Cepeda J, Wu J, Trestman RL, Altice FL, Springer SA. Optimization of Human Immunodeficiency Virus Treatment During Incarceration: Viral Suppression at the Prison Gate. JAMA Internal Medicine 2014, 174: 721-729. PMID: 24687044, PMCID: PMC4074594, DOI: 10.1001/jamainternmed.2014.601.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsCD4 lymphocyte countViral suppressionHIV viral suppressionLymphocyte countObserved therapyRNA levelsBaseline HIV-1 RNA levelsMean HIV-1 RNA levelHuman immunodeficiency virus (HIV) treatmentHuman immunodeficiency virus managementHIV treatment outcomesRetrospective cohort studyAntiretroviral therapy regimensHIV-1 RNAPsychiatric disorder severityLogistic regression modelsCommunity-based resourcesDuration of incarcerationRace/ethnicityART regimenContinuous ARTPrescribed pharmacotherapyAntiretroviral therapyART regimens
2013
Partner violence and health among HIV-infected jail detainees
Meyer JP, Wickersham JA, Fu JJ, Brown SE, Sullivan TP, Springer SA, Altice FL. Partner violence and health among HIV-infected jail detainees. International Journal Of Prisoner Health 2013, 9: 124-141. PMID: 24376468, PMCID: PMC3873166, DOI: 10.1108/ijph-03-2013-0011.Peer-Reviewed Original ResearchConceptsIntimate partner violenceSubstance use disordersHIV treatment outcomesHealthcare utilizationPartner violenceTreatment outcomesJail detaineesIPV exposureEffects of IPVHIV secondary preventionPost-release interventionsUntreated mental disordersDepth qualitative interviewsLifetime IPV exposureForms of childhoodHigher alcohol use severityCriminal justice populationsAlcohol use severityViolence reductionCJ populationsTime of incarcerationHIV diagnosisSecondary preventionAdulthood abuseQualitative interviewsLatent Tuberculosis Infection: Screening and Treatment in an Urban Setting
Morano JP, Walton MR, Zelenev A, Bruce RD, Altice FL. Latent Tuberculosis Infection: Screening and Treatment in an Urban Setting. Journal Of Community Health 2013, 38: 941-950. PMID: 23728822, PMCID: PMC3781590, DOI: 10.1007/s10900-013-9704-y.Peer-Reviewed Original ResearchConceptsIsoniazid preventative therapyLatent tuberculosis infectionTuberculin skin testSelf-administered therapyActive tuberculosisRecent incarcerationNew latent tuberculosis infectionsPositive tuberculin skin testMobile outreach clinicHigh tuberculosis prevalenceMultivariate logistic regressionInner-city populationDOT participantsLTBI treatmentObserved therapyTuberculosis infectionPreventative therapySkin testChest radiographsTuberculosis prevalenceOutreach clinicsCXR screeningHealthcare clinicsYounger ageSimilar outcomesIntegrating buprenorphine maintenance therapy into federally qualified health centers: Real-world substance abuse treatment outcomes
Haddad MS, Zelenev A, Altice FL. Integrating buprenorphine maintenance therapy into federally qualified health centers: Real-world substance abuse treatment outcomes. Drug And Alcohol Dependence 2013, 131: 127-135. PMID: 23332439, PMCID: PMC3674170, DOI: 10.1016/j.drugalcdep.2012.12.008.Peer-Reviewed Original ResearchConceptsQualified health centersSubstance abuse counselingHealth centersBuprenorphine maintenance treatment programCocaine useBuprenorphine maintenance therapyConcomitant cocaine useOpioid-dependent patientsMaintenance treatment programReal-world effectivenessSubstance abuse treatment outcomesElectronic health recordsHCV infectionMaintenance therapyPsychiatric comorbidityMean ageDependent patientsPsychiatric medicationsClinical trialsTreatment outcomesMood disordersFamily practitionersMore weeksTreatment programBMT
2012
Emergency Department Use by Released Prisoners with HIV: An Observational Longitudinal Study
Meyer JP, Qiu J, Chen NE, Larkin GL, Altice FL. Emergency Department Use by Released Prisoners with HIV: An Observational Longitudinal Study. PLOS ONE 2012, 7: e42416. PMID: 22879972, PMCID: PMC3411742, DOI: 10.1371/journal.pone.0042416.Peer-Reviewed Original ResearchConceptsED useEmergency departmentHIV careED visitsSelf-administered antiretroviral therapyMultivariate modelContinuous HIV carePrimary HIV careEmergency department useAcute febrile syndromeObservational longitudinal studyAlcohol addiction severityED contactAntiretroviral therapyComorbid diseasesHIV severityPrimary outcomeFebrile syndromeSubstance use issuesDepartment useSevere depressionGreater social supportHealthcare resourcesMental illnessPoisson regression
2011
Medication Persistence of HIV-infected Drug Users on Directly Administered Antiretroviral Therapy
Ing EC, Bae JW, Maru DS, Altice FL. Medication Persistence of HIV-infected Drug Users on Directly Administered Antiretroviral Therapy. AIDS And Behavior 2011, 17: 113-121. PMID: 22105340, DOI: 10.1007/s10461-011-0082-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBehavior, AddictiveCD4 Lymphocyte CountConnecticutDirectly Observed TherapyDrug UsersFemaleHIV InfectionsHumansInterviews as TopicKaplan-Meier EstimateMaleMedication AdherenceProportional Hazards ModelsRandomized Controlled Trials as TopicRNA, ViralSeverity of Illness IndexSubstance Abuse, IntravenousTreatment OutcomeViral LoadConceptsDrug usersAntiretroviral therapyPatterns of medicationInjection drug useMedication-taking behaviorHigher depressive symptomsVirological outcomesMedication persistenceRegimen changeMore episodesDepressive symptomsHigher addiction severityDrug useSignificant associationConsecutive daysHIVAddiction severityMedicationsMEMS dataTherapyDaysEpisodesParticipantsRegimensDAARTComputer-Based Intervention in HIV Clinical Care Setting Improves Antiretroviral Adherence: The LifeWindows Project
Fisher JD, Amico KR, Fisher WA, Cornman DH, Shuper PA, Trayling C, Redding C, Barta W, Lemieux AF, Altice FL, Dieckhaus K, Friedland G, for the LifeWindows Team. Computer-Based Intervention in HIV Clinical Care Setting Improves Antiretroviral Adherence: The LifeWindows Project. AIDS And Behavior 2011, 15: 1635. PMID: 21452051, DOI: 10.1007/s10461-011-9926-x.Peer-Reviewed Original ResearchConceptsHIV clinical care settingsAdherence support interventionsClinical care sitesClinical care settingsHIV careCare visitsAntiretroviral adherenceControl armCare settingsCare sitesProtocol interventionTreat sampleProtocol sampleSupport interventionsComputer-based interventionsIntervention impactControl participantsInterventionAdherenceHIVPatientsCareHigh levelsClinicARV