2022
Reinfection and Risk Behaviors After Treatment of Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy : A Cohort Study.
Grebely J, Dore GJ, Altice FL, Conway B, Litwin AH, Norton BL, Dalgard O, Gane EJ, Shibolet O, Nahass R, Luetkemeyer AF, Peng CY, Iser D, Gendrano IN, Kelly MM, Hwang P, Asante-Appiah E, Haber BA, Barr E, Robertson MN, Platt H. Reinfection and Risk Behaviors After Treatment of Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy : A Cohort Study. Annals Of Internal Medicine 2022, 175: 1221-1229. PMID: 35939812, DOI: 10.7326/m21-4119.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyLong-term extension studyHCV reinfectionDrug useExtension studyAgonist therapySuccessful treatmentHepatitis C virus (HCV) reinfectionHepatitis C virus infectionBenefits of cureC virus infectionChronic HCV infectionRate of reinfectionUrine drug screeningOngoing drug useClinical trial sitesSubsidiary of MerckHCV infectionCohort studyVirus reinfectionDohme Corp.Treatment completionGenotype 1Virus infectionHigh risk
2021
Individual and poly-substance use and condomless sex among HIV-uninfected adults reporting heterosexual sex in a multi-site cohort
Fredericksen RJ, Whitney BM, Trejo E, Nance RM, Fitzsimmons E, Altice FL, Carrico AW, Cleland CM, Del Rio C, Duerr A, El-Sadr WM, Kahana S, Kuo I, Mayer K, Mehta S, Ouellet LJ, Quan VM, Rich J, Seal DW, Springer S, Taxman F, Wechsberg W, Crane HM, Delaney JAC. Individual and poly-substance use and condomless sex among HIV-uninfected adults reporting heterosexual sex in a multi-site cohort. BMC Public Health 2021, 21: 2002. PMID: 34736425, PMCID: PMC8567631, DOI: 10.1186/s12889-021-12026-7.Peer-Reviewed Original ResearchConceptsLikelihood of CSRecent substance useHIV-negative partnersVaginal sexAnal sexSubstance useHIV-status unknown partnersMultivariable relative risk regressionExposure classificationType of sexHIV-negative adultsPooled effect estimatesPartner's HIV statusMulti-site cohortHigher likelihoodHeterosexual sexRelative risk regressionSingle substance usePoly-substance useHIV-negativeHIV statusRisk regressionPolysubstance useCannabis useSU exposure
2018
HIV Sero-Status Non-disclosure Among HIV-Infected Opioid-Dependent Individuals: The Roles of HIV-Related Stigma, Risk Behavior, and Social Support
Shrestha R, Altice FL, Sibilio B, Copenhaver MM. HIV Sero-Status Non-disclosure Among HIV-Infected Opioid-Dependent Individuals: The Roles of HIV-Related Stigma, Risk Behavior, and Social Support. Journal Of Community Health 2018, 44: 112-120. PMID: 30043195, PMCID: PMC6330145, DOI: 10.1007/s10900-018-0560-7.Peer-Reviewed Original ResearchConceptsOpioid-dependent individualsOpioid-dependent patientsHIV statusFamily/friendsSexual partnersHIV disclosureHIV sero-status disclosureRisk behaviorsHIV sero statusAntiretroviral therapy adherenceHigh-risk HIVRole of HIVMultivariable logistic regressionSubstance abuse treatment settingsHIV risk behaviorsInconsistent condom useMultiple sex partnersSocial supportHigh HIVSero statusHIV transmissionTherapy adherenceIndependent correlatesHIV riskHIV stigma
2017
The effects of opioid-agonist treatments on HIV risk and social stability: A mixed methods study of women with opioid use disorder in Ukraine
Hoff E, Marcus R, Bojko MJ, Makarenko I, Mazhnaya A, Altice FL, Meyer JP. The effects of opioid-agonist treatments on HIV risk and social stability: A mixed methods study of women with opioid use disorder in Ukraine. Journal Of Substance Use And Addiction Treatment 2017, 83: 36-44. PMID: 29129194, PMCID: PMC5726590, DOI: 10.1016/j.jsat.2017.10.003.Peer-Reviewed Original ResearchGender Differences in HIV Risk Behaviors Among Persons Involved in the U.S. Criminal Justice System and Living with HIV or at Risk for HIV: A “Seek, Test, Treat, and Retain” Harmonization Consortium
Loeliger KB, Biggs ML, Young R, Seal DW, Beckwith CG, Kuo I, Gordon MS, Altice FL, Ouellet LJ, Cunningham WE, Young JD, Springer SA. Gender Differences in HIV Risk Behaviors Among Persons Involved in the U.S. Criminal Justice System and Living with HIV or at Risk for HIV: A “Seek, Test, Treat, and Retain” Harmonization Consortium. AIDS And Behavior 2017, 21: 2945-2957. PMID: 28188460, PMCID: PMC5552433, DOI: 10.1007/s10461-017-1722-9.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsRisk behaviorsHIV risk reduction interventionsHIV-negative participantsHIV-positive womenHIV-positive menMultilevel mixed-effects logistic regression modelSero-discordant partnersMixed effects logistic regression modelsCondomless sexual intercourseRisk reduction interventionsLogistic regression modelsCJ populationsBehavior Assessment ToolHIV transmissionCriminal justice populationsHigher oddsHIVReduction interventionsSexual intercourseLarge-scale studiesBaseline dataInjection equipmentJustice populationsAssessment tool
2016
Examining the Acceptability of mHealth Technology in HIV Prevention Among High-Risk Drug Users in Treatment
Shrestha R, Huedo-Medina TB, Altice FL, Krishnan A, Copenhaver M. Examining the Acceptability of mHealth Technology in HIV Prevention Among High-Risk Drug Users in Treatment. AIDS And Behavior 2016, 21: 3100-3110. PMID: 28025735, PMCID: PMC5484759, DOI: 10.1007/s10461-016-1637-x.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultCell PhoneConnecticutDelivery of Health CareDrug UsersFemaleHIV InfectionsHumansInternetMaleMethadoneNeurocognitive DisordersOpiate Substitution TreatmentPatient Acceptance of Health CarePrevalenceRisk FactorsRisk-TakingSexual BehaviorSmartphoneSubstance Abuse, IntravenousTelemedicineText MessagingConceptsSex-related risk behaviorsNeurocognitive impairmentDrug usersRisk behaviorsHIV-negative drug usersHigh-risk drug usersHigh-risk populationHigh-risk peopleHIV prevention effortsUse of mHealthMethadone clinicsHIV preventionHigh prevalenceMedication remindersHealth programsMHealth acceptancePrevention effortsHealth conditionsMHealth technologiesConvenience sampleDrugsStandardized assessmentReal-world acceptanceMobile healthPhone callsPretreatment Drug use Characteristics and Experiences among Patients in a Voluntary Substance Abuse Treatment Center in Malaysia: A Mixed-Methods Approach
Krishnan A, Brown SE, Ghani MA, Khan F, Kamarulzaman A, Altice FL. Pretreatment Drug use Characteristics and Experiences among Patients in a Voluntary Substance Abuse Treatment Center in Malaysia: A Mixed-Methods Approach. Substance Abuse 2016, 37: 542-549. PMID: 26914230, PMCID: PMC5551393, DOI: 10.1080/08897077.2016.1146648.Peer-Reviewed Original ResearchConceptsCompulsory drug detention centersDrug use characteristicsDrug useAmphetamine useTreatment centersDrug usersVoluntary drug treatment centresIllicit amphetamine useInjection drug useDrug treatment centersSubstance abuse treatment centersDrug use patternsDrug use profilesHigh-risk behaviorsSignificant public healthDrug initiationCare centerHigh prevalencePolysubstance useNortheast MalaysiaAddiction severityPatientsBehavioral interventionsAddiction treatmentConvenience samplePre‐incarceration police harassment, drug addiction and HIV risk behaviours among prisoners in Kyrgyzstan and Azerbaijan: results from a nationally representative cross‐sectional study
Polonsky M, Azbel L, Wegman MP, Izenberg JM, Bachireddy C, Wickersham JA, Dvoriak S, Altice FL. Pre‐incarceration police harassment, drug addiction and HIV risk behaviours among prisoners in Kyrgyzstan and Azerbaijan: results from a nationally representative cross‐sectional study. Journal Of The International AIDS Society 2016, 19: 20880. PMID: 27435715, PMCID: PMC4951538, DOI: 10.7448/ias.19.4.20880.Peer-Reviewed Original ResearchConceptsRepresentative cross-sectional studyHIV risk behaviorsCross-sectional studyHIV riskAddiction severityRisk behaviorsHIV risk-taking behaviorsPrison drug injectionDrug addiction severityHealth assessment surveyHIV transmissionPotential confoundersDrug injectionHIV epidemicDrug usersHigher addiction severityDrug useBivariate testingThird of prisonersDrug addictionSeverityPWIDEpidemic responseRiskStrongest correlatePublic health and international drug policy
Csete J, Kamarulzaman A, Kazatchkine M, Altice F, Balicki M, Buxton J, Cepeda J, Comfort M, Goosby E, Goulão J, Hart C, Kerr T, Lajous AM, Lewis S, Martin N, Mejía D, Camacho A, Mathieson D, Obot I, Ogunrombi A, Sherman S, Stone J, Vallath N, Vickerman P, Zábranský T, Beyrer C. Public health and international drug policy. The Lancet 2016, 387: 1427-1480. PMID: 27021149, PMCID: PMC5042332, DOI: 10.1016/s0140-6736(16)00619-x.Peer-Reviewed Original Research
2015
Patterns of substance use and correlates of lifetime and active injection drug use among women in Malaysia
Wickersham JA, Loeliger KB, Marcus R, Pillai V, Kamarulzaman A, Altice FL. Patterns of substance use and correlates of lifetime and active injection drug use among women in Malaysia. The American Journal Of Drug And Alcohol Abuse 2015, 42: 98-110. PMID: 26636885, PMCID: PMC4837957, DOI: 10.3109/00952990.2015.1101467.Peer-Reviewed Original ResearchConceptsNeedle-syringe exchange programsDrug injectionCorrelates of lifetimeDrug usePolysubstance useInjection-related risk behaviorsActive injection drug useSelf-reported HIV statusAgonist maintenance therapyLifetime drug injectionOpioid/benzodiazepineSubstance useInjection drug useHarm reduction servicesDrug use historyHarm reduction measuresPrior criminal justice involvementOAT servicesMaintenance therapyOpioid useHIV statusHIV transmissionRisk factorsCriminal justice involvementHIV riskThe syndemic of HIV, HIV-related risk and multiple co-morbidities among women who use drugs in Malaysia: Important targets for intervention
Loeliger KB, Marcus R, Wickersham JA, Pillai V, Kamarulzaman A, Altice FL. The syndemic of HIV, HIV-related risk and multiple co-morbidities among women who use drugs in Malaysia: Important targets for intervention. Addictive Behaviors 2015, 53: 31-39. PMID: 26436520, PMCID: PMC4679569, DOI: 10.1016/j.addbeh.2015.09.013.Peer-Reviewed Original ResearchConceptsDrug-using womenHIV testingFuture public health interventionsSubstance useHIV risk behaviorsSyndemics of HIVThird of womenPublic health problemInfrequent condom usePoor health outcomesHarm reduction effortsSubstance use disordersPublic health interventionsCross-sectional surveyUnstable living situationsSocial supportAntiretroviral therapyHIV prevalenceHIV transmissionHIV treatmentInjection paraphernaliaDrug injectionSocial comorbiditiesPsychiatric illnessMost womenLatent class analysis of substance use among men who have sex with men in Malaysia: Findings from the Asian Internet MSM Sex Survey
Lim SH, Cheung DH, Guadamuz TE, Wei C, Koe S, Altice FL. Latent class analysis of substance use among men who have sex with men in Malaysia: Findings from the Asian Internet MSM Sex Survey. Drug And Alcohol Dependence 2015, 151: 31-37. PMID: 25865907, DOI: 10.1016/j.drugalcdep.2015.02.040.Peer-Reviewed Original ResearchConceptsSubstance useMalaysian MSMMultinational online surveyAmphetamine-type stimulant useMale sex partnersInconsistent condom useSexual risk behaviorsSubstance use patternsRecreational drug useErectile dysfunction drugsHIV statusHIV epidemicHIV preventionRisk groupsHigh prevalenceATS useSex partnersDrug useCondom useRisk behaviorsRisk profileStimulant useGroup sexMSMLatent class analysisPrevalence and Predictors of Mental/Emotional Distress Among HIV+ Jail Detainees at Enrollment in an Observational Study
Lincoln T, Simon-Levine D, Smith J, Donenberg GR, Springer SA, Zaller N, Altice FL, Moore K, Jordan AO, Draine J, Desabrais M. Prevalence and Predictors of Mental/Emotional Distress Among HIV+ Jail Detainees at Enrollment in an Observational Study. Journal Of Correctional Health Care 2015, 21: 125-139. PMID: 25788608, PMCID: PMC4433291, DOI: 10.1177/1078345815574566.Peer-Reviewed Original ResearchConceptsEmotional distressJail detaineesSeverity Index scoreAddiction Severity Index (ASI) scoresPoor physical healthMental health assessmentHIV/AIDSEmotional distress scoresObservational studyIndex scoreDistress scoresHealth servicesHealth RankingsSubstance abusePhysical healthJail systemHealth assessmentBisexual orientationSpecific correlatesDistressFamily supportPrevalenceScoresHigh levelsPLWHAWithin-prison drug injection among HIV-infected male prisoners in Indonesia: A highly constrained choice
Culbert GJ, Waluyo A, Iriyanti M, Muchransyah AP, Kamarulzaman A, Altice FL. Within-prison drug injection among HIV-infected male prisoners in Indonesia: A highly constrained choice. Drug And Alcohol Dependence 2015, 149: 71-79. PMID: 25659895, PMCID: PMC5108518, DOI: 10.1016/j.drugalcdep.2015.01.018.Peer-Reviewed Original ResearchConceptsPrison drug injectionDrug injectionNeedle sharingDaily drug injectionsIncarceration of peopleDrug use changesSubstance use disordersHigh-risk behaviorsMale prisonersVoice-recorded interviewsHalf of participantsHIV transmissionHIV treatmentMultivariate correlatesUse disordersHIVDrug usersMultivariate analysisRisk behaviorsLogistic regressionStigmatizing attitudesDrug availabilityDrug cravingAddiction treatmentDrug supply
2014
Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for HIV-infected, opioid dependent prisoners and jail detainees who are transitioning to the community
Di Paola A, Lincoln T, Skiest DJ, Desabrais M, Altice FL, Springer SA. Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for HIV-infected, opioid dependent prisoners and jail detainees who are transitioning to the community. Contemporary Clinical Trials 2014, 39: 256-268. PMID: 25240704, PMCID: PMC4283549, DOI: 10.1016/j.cct.2014.09.002.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentPlacebo-controlled trialXR-NTXAgonist treatmentOpioid dependenceTreatment outcomesPoor HIV treatment outcomesOpioid treatment outcomesOpioid-dependent prisonersExtended-release naltrexoneHIV treatment outcomesHIV transmission riskEvidence-based treatmentsCriminal justice settingsEarly acceptabilityStudy medicationFirst injectionStudy acceptabilityHIVTotal referralsJail detaineesCommunity settingsTransmission riskDrug relapseHigh internal validityWithin-prison drug injection among HIV-infected Ukrainian prisoners: Prevalence and correlates of an extremely high-risk behaviour
Izenberg JM, Bachireddy C, Wickersham JA, Soule M, Kiriazova T, Dvoriak S, Altice FL. Within-prison drug injection among HIV-infected Ukrainian prisoners: Prevalence and correlates of an extremely high-risk behaviour. International Journal Of Drug Policy 2014, 25: 845-852. PMID: 24951025, PMCID: PMC4148465, DOI: 10.1016/j.drugpo.2014.02.010.Peer-Reviewed Original ResearchConceptsInjection equipment sharingPrison drug injectionNeedle/syringeIndependent correlatesDrug injectionNeedle/syringe exchange programsDrug useOpioid substitution therapyInjection drug useEquipment sharingSyringe exchange programsHigh-risk behaviorsPrior drug useOpioid useHIV infectionHIV incidenceHIV transmissionSubstitution therapyMale genderHarm reduction practicesHIVLogistic regressionMental healthConvenience sampleComplete dataSexual Risk Behaviors Among Adolescents in Port-au-Prince, Haiti
Carver JW, Dévieux JG, Gaston SC, Altice FL, Niccolai LM. Sexual Risk Behaviors Among Adolescents in Port-au-Prince, Haiti. AIDS And Behavior 2014, 18: 1595-1603. PMID: 24402691, PMCID: PMC5572216, DOI: 10.1007/s10461-013-0689-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorCondomsCross-Sectional StudiesEducational StatusFamily CharacteristicsFemaleHaitiHealth Knowledge, Attitudes, PracticeHumansMaleRisk FactorsRisk-TakingSexual PartnersSexually Transmitted DiseasesSocial DesirabilitySocial EnvironmentSurveys and QuestionnairesConceptsSexual risk behaviorsRisk behaviorsPresent cross-sectional studyCross-sectional studyHIV prevention effortsIndependent correlatesAdult family membersYear old adolescentsHigh prevalenceLast sexUnprotected sexSexual partnersSexual debutPrevention effortsSexual intercourseProtective influenceSexual activityMultivariate modelingRisky sexSexAge 14Port-auFace interviewsAdolescentsFamily members
2013
Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community
Springer SA, Altice FL, Herme M, Di Paola A. Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community. Contemporary Clinical Trials 2013, 37: 209-218. PMID: 24384538, PMCID: PMC3992862, DOI: 10.1016/j.cct.2013.12.006.Peer-Reviewed Original ResearchConceptsPlacebo-controlled trialHIV treatment outcomesTreatment outcomesCriminal justice system (CJS) populationsPoor antiretroviral therapy (ART) adherenceAlcohol useExtended-release naltrexoneAntiretroviral therapy adherenceMedication-assisted therapyPrevention of relapseAlcohol use disorderSexual risk-taking behaviorsAlcohol-dependent personsXR-NTXHigh morbidityTherapy adherenceAlcohol relapseHigh prevalenceStudy participationEligibility criteriaUse disordersHIVRelapseHazardous drinkingNaltrexoneA systematic review of alcohol use and sexual risk-taking in Latin America.
Vagenas P, Lama JR, Ludford KT, Gonzales P, Sanchez J, Altice FL. A systematic review of alcohol use and sexual risk-taking in Latin America. BULL PAN AM HEALTH ORGAN 2013, 34: 267-74. PMID: 24301738, PMCID: PMC3895327.Peer-Reviewed Original ResearchScreening for Drug and Alcohol Use Disorders and Their Association with HIV-Related Sexual Risk Behaviors among Men Who Have Sex with Men in Peru
Ludford KT, Vagenas P, Lama JR, Peinado J, Gonzales P, Leiva R, Pun M, Sanchez J, Altice FL, . Screening for Drug and Alcohol Use Disorders and Their Association with HIV-Related Sexual Risk Behaviors among Men Who Have Sex with Men in Peru. PLOS ONE 2013, 8: e69966. PMID: 23936364, PMCID: PMC3735581, DOI: 10.1371/journal.pone.0069966.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAdjusted odds ratioAlcohol Use Disorders Identification TestHIV transmissionSexual risk behaviorsHIV epidemicUse disordersCross-sectional bio-behavioural surveyUnprotected sexSexual partnersRisk behaviorsHIV risk-taking behaviorsIncident HIV infectionBio-behavioural surveyMedication-assisted therapyRecent drug useDisorders Identification TestHigh-risk behaviorsLast encounterDependent outcomesHIV infectionMajority of participantsActive MSMIndependent correlatesOdds ratio