2020
The real‐world impact of dosing of methadone and buprenorphine in retention on opioid agonist therapies in Ukraine
Farnum SO, Makarenko I, Madden L, Mazhnaya A, Marcus R, Prokhorova T, Bojko MJ, Rozanova J, Dvoriak S, Islam Z, Altice FL. The real‐world impact of dosing of methadone and buprenorphine in retention on opioid agonist therapies in Ukraine. Addiction 2020, 116: 83-93. PMID: 32428276, PMCID: PMC7674222, DOI: 10.1111/add.15115.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOAT discontinuationAgonist therapyTreatment retentionIndependent predictorsHIV epidemicCost-effective HIV prevention strategyMethadone maintenance treatment patientsObservational longitudinal cohort studySpecialty addictions treatmentBuprenorphine maintenance treatmentHigh dosageHIV prevention strategiesLongitudinal cohort studyOpioid-dependent peopleTreatment discontinuationCohort studyMaintenance treatmentMale sexTreatment patientsPrevention strategiesDiscontinuationYounger ageCenter settingAddiction treatment
2019
Staying hepatitis C negative: A systematic review and meta‐analysis of cure and reinfection in people who inject drugs
Latham NH, Doyle JS, Palmer AY, Vanhommerig JW, Agius P, Goutzamanis S, Li Z, Pedrana A, Gottfredsson M, Bouscaillou J, Luhmann N, Mazhnaya A, Altice FL, Saeed S, Klein M, Falade‐Nwulia O, Aspinall E, Hutchinson S, Hellard ME, Sacks‐Davis R. Staying hepatitis C negative: A systematic review and meta‐analysis of cure and reinfection in people who inject drugs. Liver International 2019, 39: 2244-2260. PMID: 31125496, DOI: 10.1111/liv.14152.Peer-Reviewed Original ResearchConceptsSustained viral responseDirect-acting antiviralsRecent PWIDOST recipientsTreatment discontinuationPerson yearsReinfection rateRelative riskTreatment outcomesSystematic reviewIncidence of reinfectionTreatment discontinuation ratesPooled relative riskHepatitis C treatmentNewcastle-Ottawa ScaleMixed effects linear modelTherapy recipientsDiscontinuation ratesHepatitis C.Pooled incidenceViral responseCure rateRecent injectingStudy qualityPWID
2013
Methadone treatment improves tuberculosis treatment among hospitalized opioid dependent patients in Ukraine
Morozova O, Dvoryak S, Altice FL. Methadone treatment improves tuberculosis treatment among hospitalized opioid dependent patients in Ukraine. International Journal Of Drug Policy 2013, 24: e91-e98. PMID: 24360402, PMCID: PMC5553122, DOI: 10.1016/j.drugpo.2013.09.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidAntitubercular AgentsDelivery of Health Care, IntegratedDrug UsersFemaleHealth Knowledge, Attitudes, PracticeHeroin DependenceHumansInpatientsMaleMedication AdherenceMethadoneOpiate Substitution TreatmentProspective StudiesRisk FactorsTime FactorsTreatment OutcomeTuberculosisUkraineConceptsTB medication adherenceMethadone maintenanceTB treatmentMedication adherenceTreatment discontinuationMulti-drug resistant tuberculosisInpatient TB treatmentNumerous treatment challengesTB treatment completionOnly independent predictorOpioid-dependent patientsIndependent predictorsPrimary outcomeOpioid dependenceResistant tuberculosisMethadone treatmentTB facilitiesTreatment optionsDependent patientsTuberculosis treatmentTreatment completionTreatment challengesObservational studyMMT groupTreatment retention