2013
Quantifying the local resolution of cryo-EM density maps
Kucukelbir A, Sigworth FJ, Tagare HD. Quantifying the local resolution of cryo-EM density maps. Nature Methods 2013, 11: 63-65. PMID: 24213166, PMCID: PMC3903095, DOI: 10.1038/nmeth.2727.Peer-Reviewed Original Research
2002
Applying Hidden Markov Models to the Analysis of Single Ion Channel Activity
Venkataramanan L, Sigworth F. Applying Hidden Markov Models to the Analysis of Single Ion Channel Activity. Biophysical Journal 2002, 82: 1930-1942. PMID: 11916851, PMCID: PMC1301989, DOI: 10.1016/s0006-3495(02)75542-2.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBiophysicsIonsKineticsLikelihood FunctionsMarkov ChainsModels, StatisticalModels, TheoreticalPatch-Clamp TechniquesTime FactorsConceptsCorrelated background noiseHidden Markov ModelDigital inverse filterMarkov model parametersDiscrete timeBaum-Welch algorithmMarkov modelComputational intensityDeterministic interferenceModel parametersInverse filterMultiple data setsAlgorithmPrevious resultsPractical applicationsNoise ratioState transitionsSharp frequencyData setsChannel dataSingle ion channel currentsNoiseExtensionRandomnessBackground noise
1999
Two-Microelectrode Voltage Clamp of Xenopus Oocytes: Voltage Errors and Compensation for Local Current Flow
Baumgartner W, Islas L, Sigworth F. Two-Microelectrode Voltage Clamp of Xenopus Oocytes: Voltage Errors and Compensation for Local Current Flow. Biophysical Journal 1999, 77: 1980-1991. PMID: 10512818, PMCID: PMC1300479, DOI: 10.1016/s0006-3495(99)77039-6.Peer-Reviewed Original Research