1995
Design of the EPC-9, a computer-controlled patch-clamp amplifier. 2. Software
Sigworth F, Affolter H, Neher E. Design of the EPC-9, a computer-controlled patch-clamp amplifier. 2. Software. Journal Of Neuroscience Methods 1995, 56: 203-215. PMID: 7538621, DOI: 10.1016/0165-0270(94)00129-5.Peer-Reviewed Original Research
1994
Voltage gating of ion channels
Sigworth F. Voltage gating of ion channels. Quarterly Reviews Of Biophysics 1994, 27: 1-40. PMID: 7520590, DOI: 10.1017/s0033583500002894.Peer-Reviewed Original ResearchConceptsVoltage-gated calcium channelsNerve action potentialsVoltage-gated sodium channelsRelease of hormonesIon channelsVoltage-gated ion channelsCalcium channelsAction potentialsNeurotransmitter releaseMuscle contractionSodium channelsMembrane proteinsCellular signalsVoltage gatingCentral roleHormoneRelease
1991
Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters
Heinemann S, Sigworth F. Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters. Biophysical Journal 1991, 60: 577-587. PMID: 1718467, PMCID: PMC1260101, DOI: 10.1016/s0006-3495(91)82087-2.Peer-Reviewed Original Research
1990
Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels
Heinemann S, Sigworth F. Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels. Biophysical Journal 1990, 57: 499-514. PMID: 1689592, PMCID: PMC1280744, DOI: 10.1016/s0006-3495(90)82566-2.Peer-Reviewed Original Research
1988
Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels
Heinemann S, Sigworth F. Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels. Biophysical Journal 1988, 54: 757-764. PMID: 2465033, PMCID: PMC1330382, DOI: 10.1016/s0006-3495(88)83013-3.Peer-Reviewed Original ResearchConceptsBiological ion channelsGramicidin A channelsTime resolutionCurrent histogramFast time scaleOpen channel noiseCharacteristic timeNoise measurementsSingle-channel experimentsNoise experimentsDirect measurementTime scalesA channelsSpectral densityBandwidth limitationsCurrentTheoretical approachMeasurementsIon channelsBlocking processChannelsSingle-channel recordingsSingle-channel currentsNoiseDependence
1987
Data transformations for improved display and fitting of single-channel dwell time histograms
Sigworth F, Sine S. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophysical Journal 1987, 52: 1047-1054. PMID: 2447968, PMCID: PMC1330104, DOI: 10.1016/s0006-3495(87)83298-8.Peer-Reviewed Original Research
1986
Open channel noise. II. A test for coupling between current fluctuations and conformational transitions in the acetylcholine receptor
Sigworth F. Open channel noise. II. A test for coupling between current fluctuations and conformational transitions in the acetylcholine receptor. Biophysical Journal 1986, 49: 1041-1046. PMID: 2423148, PMCID: PMC1329684, DOI: 10.1016/s0006-3495(86)83732-8.Peer-Reviewed Original Research