1997
Enhanced Closed-state Inactivation in a Mutant Shaker K+ Channel
Ayer, Jr. R, Sigworth F. Enhanced Closed-state Inactivation in a Mutant Shaker K+ Channel. The Journal Of Membrane Biology 1997, 157: 215-230. PMID: 9178609, DOI: 10.1007/s002329900230.Peer-Reviewed Original Research
1993
Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly
McCormack K, Lin L, Sigworth F. Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly. Biophysical Journal 1993, 65: 1740-1748. PMID: 8274662, PMCID: PMC1225901, DOI: 10.1016/s0006-3495(93)81202-5.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBiophysical PhenomenaBiophysicsDNA, ComplementaryDrosophilaDrug StabilityFemaleIon Channel GatingMembrane PotentialsMolecular Sequence DataMutagenesis, Site-DirectedOocytesPeptidesPotassium ChannelsProtein ConformationShaker Superfamily of Potassium ChannelsThermodynamicsXenopus laevisConceptsUncharged amino acid residuesLeucine heptad repeatWild-type subunitsPosition 370Large hydrophobic residuesAmino acid residuesSequence motifsConservative substitutionsHeptad repeatHydrophobic residuesVoltage-gated channelsLeucine residuesAcid residuesTertiary structureS4 segmentSpecific hydrophobic interactionsHydrophilic residuesResidue altersChannel subunitsInactivation gatingChannel complexSubunitsConformational stabilityConformational transitionResidues
1992
Tandem linkage of Shaker K+ channel subunits does not ensure the stoichiometry of expressed channels
McCormack K, Lin L, Iverson L, Tanouye M, Sigworth F. Tandem linkage of Shaker K+ channel subunits does not ensure the stoichiometry of expressed channels. Biophysical Journal 1992, 63: 1406-1411. PMID: 1477286, PMCID: PMC1261445, DOI: 10.1016/s0006-3495(92)81703-4.Peer-Reviewed Original Research