2016
Equilibrium gated radionuclide angiocardiography: Its invention, rise, and decline and … comeback?
Wackers FJ. Equilibrium gated radionuclide angiocardiography: Its invention, rise, and decline and … comeback? Journal Of Nuclear Cardiology 2016, 23: 362-365. PMID: 26818145, DOI: 10.1007/s12350-016-0414-6.Peer-Reviewed Original ResearchAngiocardiographyGated Blood-Pool ImagingHeartInventionsRadioisotopesRadionuclide ImagingStroke Volume
2015
Has LVEF changed beyond chance? Limits of agreement of radiotracer-derived LVEF
Wackers FJ. Has LVEF changed beyond chance? Limits of agreement of radiotracer-derived LVEF. Journal Of Nuclear Cardiology 2015, 22: 1244-1246. PMID: 25698484, DOI: 10.1007/s12350-015-0090-y.Peer-Reviewed Original ResearchGated Blood-Pool ImagingStroke Volume
2012
Left Ventricular Ejection Fraction and Left Ventricular End‐Diastolic Volume in Patients With Diastolic Dysfunction
Jovin IS, Ebisu K, Liu Y, Finta LA, Oprea AD, Brandt CA, Dziura J, Wackers FJ. Left Ventricular Ejection Fraction and Left Ventricular End‐Diastolic Volume in Patients With Diastolic Dysfunction. Congestive Heart Failure 2012, 19: 130-134. PMID: 23241105, DOI: 10.1111/chf.12013.Peer-Reviewed Original ResearchMeSH KeywordsDiastoleFemaleFollow-Up StudiesGated Blood-Pool ImagingHeartHumansMaleMiddle AgedReproducibility of ResultsRetrospective StudiesStroke VolumeVentricular Dysfunction, LeftConceptsLVEF of patientsLeft ventricular ejection fractionLower peak filling ratePeak filling rateEnd-diastolic volumeNormal peak filling ratesEquilibrium radionuclide angiocardiographyVentricular ejection fractionDiastolic dysfunctionAsymptomatic patientsEjection fractionLow left ventricular ejection fractionNormal left ventricular ejection fractionVentricular end-diastolic volumeMild systolic dysfunctionNormal systolic functionEDV indexSystolic dysfunctionSystolic functionRadionuclide angiocardiographyPatientsDysfunctionRepeat scansFilling rateAngiocardiographyAcute chest pain of uncertain etiology, the short and long view
Wackers F. Acute chest pain of uncertain etiology, the short and long view. Journal Of Nuclear Cardiology 2012, 19: 220-223. PMID: 22271368, DOI: 10.1007/s12350-012-9514-0.Peer-Reviewed Original Research
2009
Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging
Senior R, Monaghan M, Main M, Zamorano J, Tiemann K, Agati L, Weissman N, Klein A, Marwick T, Ahmad M, DeMaria A, Zabalgoitia M, Becher H, Kaul S, Udelson J, Wackers F, Walovitch R, Picard M. Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. European Heart Journal - Cardiovascular Imaging 2009, 10: 26-35. PMID: 19131498, DOI: 10.1093/ejechocard/jen321.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overArea Under CurveContrast MediaCoronary Artery DiseaseDipyridamoleEchocardiography, StressFemaleFluorocarbonsGated Blood-Pool ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedInternational CooperationMaleMiddle AgedObserver VariationROC CurveSensitivity and SpecificityStatistics, NonparametricTomography, Emission-Computed, Single-PhotonYoung AdultConceptsChest pain patientsPain patientsStress echocardiographyPerfusion imagingNon-inferior sensitivityPhase 3 trialCoronary artery diseaseCoronary artery disease detectionQuantitative coronary angiographyNon-inferiority analysisRadionuclide perfusion imagingSingle photon emissionAdverse eventsArtery diseaseCoronary angiographyBlinded cardiologistsClinical reviewDipyridamole stressMyocardial perfusionSPECT perfusionInternational trialRAMP 1Diagnostic performanceSPECTCharacteristic curve
2005
New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation
Liu YH, Sinusas AJ, Khaimov D, Gebuza BI, Wackers FJ. New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation. Journal Of Nuclear Cardiology 2005, 12: 55-65. PMID: 15682366, DOI: 10.1016/j.nuclcard.2004.09.015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsElectrocardiographyFemaleGated Blood-Pool ImagingHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexStroke VolumeTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, Left
2003
Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction
Navare SM, Wackers FJ, Liu YH. Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction. European Journal Of Nuclear Medicine And Molecular Imaging 2003, 30: 1330-1337. PMID: 12838373, DOI: 10.1007/s00259-003-1231-0.Peer-Reviewed Original ResearchConceptsSingle photon emission tomographyEnd-diastolic volumeEnd-systolic volumePerfusion defectsEjection fractionMyocardial perfusionSPET imagesLV volumesLeft ventricular end-diastolic volumeVentricular end-diastolic volumeSmaller end-systolic volumeLarger end-diastolic volumeSignificant perfusion defectsMyocardial perfusion defectsRadiotracer doseHigher LVEFVentricular functionLow doseVentricular volumeEmission tomographyLV parametersDoseLVEFECG gatingPatients
2000
Effect of left ventricular volume on results of coronary artery bypass grafting
Kim R, Ugurlu B, Tereb D, Wackers F, Tellides G, Elefteriades J. Effect of left ventricular volume on results of coronary artery bypass grafting. The American Journal Of Cardiology 2000, 86: 1261-1264. PMID: 11090805, DOI: 10.1016/s0002-9149(00)01216-9.Peer-Reviewed Original ResearchConceptsCoronary artery bypassArtery bypassSignificant left ventricular dilationLeft ventricular dilationLV chamber sizeLV ejection fractionMedium-term survivalSurgical revascularizationAngina symptomsEjection fractionIschemic cardiomyopathyLV dilationVentricular dilationVentricular sizeVentricular volumePatientsSignificant reductionBypassChamber sizeDilationRevascularizationCardiomyopathySymptoms
1999
Ejection fraction by radionuclide ventriculography and contrast left ventriculogram A tale of two techniques
Ureña P, Lamas G, Mitchell G, Flaker G, Smith S, Wackers F, McEwan P, Pfeffer M, investigators F. Ejection fraction by radionuclide ventriculography and contrast left ventriculogram A tale of two techniques. Journal Of The American College Of Cardiology 1999, 33: 180-185. PMID: 9935027, DOI: 10.1016/s0735-1097(98)00533-6.Peer-Reviewed Original ResearchConceptsRadionuclide ventriculographyEjection fractionCardiovascular eventsEvent ratesMyocardial infarctionPostinfarct patientsIndependent predictorsRisk stratificationAssess prognosisClinical eventsVentricular performanceClinical impressionPatientsMultivariate analysisPrognosisVentriculographyTercileEF measurementsBest predictorPredictorsComparative abilityCatheterizationInfarctionVentriculograms
1996
Prognostic value of noninvasive testing one year after orthotopic cardiac transplantation
Verhoeven P, Lee F, Ramahi T, Franco K, de Leon C, Amatruda J, Gorham N, Mattera J, Wackers F. Prognostic value of noninvasive testing one year after orthotopic cardiac transplantation. Journal Of The American College Of Cardiology 1996, 28: 183-189. PMID: 8752812, DOI: 10.1016/0735-1097(96)00094-0.Peer-Reviewed Original ResearchConceptsCoronary artery vasculopathyOrthotopic cardiac transplantationCardiac transplantationEquilibrium radionuclide angiographyPrognostic valueRadionuclide angiographyClinical variablesNoninvasive testingHuman leukocyte antigen mismatchesStress thallium-201 imagingThallium-201 myocardial perfusion imagingConsecutive transplant recipientsRoutine noninvasive testingStress myocardial imagingCold ischemic timeStress myocardial perfusionThallium-201 imagingTwo-dimensional echocardiographyNoninvasive diagnostic testingMyocardial perfusion imagingOnly significant predictorAntigen mismatchesLate deathsTransplant recipientsIschemic timeComparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions
van Royen N, Jaffe C, Krumholz H, Johnson K, Lynch P, Natale D, Atkinson P, Demon P, Wackers F. Comparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions. The American Journal Of Cardiology 1996, 77: 843-850. PMID: 8623737, DOI: 10.1016/s0002-9149(97)89179-5.Peer-Reviewed Original ResearchConceptsEquilibrium radionuclide angiographyVentricular ejection fractionEjection fractionRadionuclide angiographyEchocardiographic LVEFEquilibrium radionuclideRadionuclide LVEFClinical relevanceLeft ventricular ejection fractionCorrelation of LVEFDetermination of LVEFPatient management decisionsPotential clinical relevanceRelevant differencesInter-observer reproducibilityStable patientsLV functionLimits of agreementLVEFIndividual patientsRepeat assessmentEchocardiographyAngiographyBlinded analysisRepeat analysis
1992
Technetium-99m sestamibi myocardial imaging at rest for assessment of myocardial infarction and first-pass ejection fraction
Boucher C, Wackers F, Zaret B, Mena I. Technetium-99m sestamibi myocardial imaging at rest for assessment of myocardial infarction and first-pass ejection fraction. The American Journal Of Cardiology 1992, 69: 22-27. PMID: 1530901, DOI: 10.1016/0002-9149(92)90670-t.Peer-Reviewed Original ResearchConceptsWall motion abnormalitiesFirst-pass ejection fractionEjection fractionQ-wave infarctsMotion abnormalitiesQ wavesAbnormal TcMyocardial infarctionSestamibi studiesFirst-pass imagingAbility of technetiumVentricular ejection fractionOccurrence of infarctionSestamibi myocardial perfusionPerfusion abnormalitiesWall motionRegional perfusionPosterior infarctsMyocardial perfusionMyocardial segmentsPatientsInfarctionSestamibi imagesProtocol IInfarcts