1998
Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy
Mattera J, Arain S, Sinusas A, Finta L, Wackers F. Exercise testing with myocardial perfusion imaging in patients with normal baseline electrocardiograms: Cost savings with a stepwise diagnostic strategy. Journal Of Nuclear Cardiology 1998, 5: 498-506. PMID: 9796897, DOI: 10.1016/s1071-3581(98)90181-7.Peer-Reviewed Original ResearchConceptsExercise myocardial perfusion imagingCoronary artery diseaseNormal exercise electrocardiogramMyocardial perfusion imagingNormal myocardial perfusion imagingNormal resting electrocardiogramsExercise electrocardiogramExercise testingArtery diseaseIntermediate likelihoodResting electrocardiogramsAbnormal myocardial perfusion imagingDiagnostic strategiesAbnormal exercise electrocardiogramGroup 3 patientsHard cardiac eventsNonfatal myocardial infarctionNormal baseline electrocardiogramSubsequent coronary revascularizationIncremental diagnostic informationDiagnostic testing strategiesCoronary revascularizationCardiac eventsUnstable anginaConsecutive patients
1997
Relevance of Increased Lung Thallium Uptake on Stress Imaging in Patients With Unstable Angina and Non-Q Wave Myocardial Infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study fn1fn1This study was supported in part by a research grant from Mallinckrodt Medical Inc., Saint Louis, Missouri.
Jain D, Thompson B, Wackers F, Zaret B, Investigators F. Relevance of Increased Lung Thallium Uptake on Stress Imaging in Patients With Unstable Angina and Non-Q Wave Myocardial Infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study fn1fn1This study was supported in part by a research grant from Mallinckrodt Medical Inc., Saint Louis, Missouri. Journal Of The American College Of Cardiology 1997, 30: 421-429. PMID: 9247514, DOI: 10.1016/s0735-1097(97)00164-2.Peer-Reviewed Original ResearchConceptsLung/heart ratioAdverse cardiac eventsNon-Q-wave myocardial infarctionCoronary artery diseaseCardiac eventsPerfusion abnormalitiesMyocardial infarctionUnstable anginaArtery diseaseStress-induced left ventricular dysfunctionHigher cardiac event rateLeft ventricular ejection fractionAggressive interventional managementHigher revascularization rateLung thallium uptakeCardiac event rateTotal exercise timeFrequency of anginaLeft ventricular dysfunctionST-segment depressionLower exercise capacityVentricular ejection fractionPrevious myocardial infarctionMyocardial perfusion abnormalitiesNormal myocardial perfusion
1996
Detection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina
Moriel M, Benhorin J, Brown M, Raubertas R, Severski P, Van Voorhees L, Bodenheimer M, Tzivoni D, Wackers F, Moss A, Group T. Detection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1996, 77: 798-804. PMID: 8623730, DOI: 10.1016/s0002-9149(97)89172-2.Peer-Reviewed Original ResearchConceptsAcute coronary eventsThallium-201 stress scintigraphyPrimary end pointCoronary eventsEnd pointUnstable anginaStress scintigraphyPatient 1Myocardial infarctionNoninvasive testsExercise electrocardiogramAmbulatory electrocardiogramIschemia detectionCardiac event rateNonfatal myocardial infarctionSubsequent cardiac eventsAcute myocardial infarctionCardiac eventsIschemia testCardiac deathCox analysisPrognostic significanceMyocardial ischemiaEvent ratesWomen
1994
Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina
Bodenheimer M, Wackers F, Schwartz R, Brown M, Group T. Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1994, 74: 1196-1200. PMID: 7977089, DOI: 10.1016/0002-9149(94)90547-9.Peer-Reviewed Original ResearchConceptsNonfatal infarctionCardiac eventsUnstable anginaCardiac deathMyocardial infarctionReversible defectsExercise thallium studiesNonfatal myocardial infarctionAcute coronary eventsLarge prospective studiesAcute cardiac eventsKaplan-Meier curvesAcute myocardial infarctionLog-rank statisticsCoronary eventsExercise thalliumPatient 1Prognostic significanceProspective studyMyocardial ischemiaThallium studiesThallium testThallium imagesInfarctionPatientsLimited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease
Krone R, Gregory J, Freedland K, Kleiger R, Wackers F, Bodenheimer M, Benhorin J, Schwartz R, Parker J, van Voorhees L, Moss A, Group F. Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease. Journal Of The American College Of Cardiology 1994, 24: 1274-1281. PMID: 7930250, DOI: 10.1016/0735-1097(94)90109-0.Peer-Reviewed Original ResearchConceptsStable coronary diseaseAcute coronary eventsNonfatal myocardial infarctionThallium-201 scintigraphyCardiac eventsCoronary eventsCoronary diseaseCardiac deathHospital admissionMyocardial infarctionNonfatal infarctionEnd pointUnstable anginaExercise testingObstructive coronary artery diseaseStable coronary heart diseaseExercise testing variablesSubsequent cardiac eventsCoronary artery diseaseGroup of patientsCoronary heart diseaseProportional hazards modelThallium perfusionCardiac causesIdentifies patients
1993
Detection and Significance of Myocardial Ischemia in Stable Patients After Recovery From an Acute Coronary Event
Moss A, Goldstein R, Hall W, Bigger J, Fleiss J, Greenberg H, Bodenheimer M, Krone R, Marcus F, Wackers F, Benhorin J, Brown M, Case R, Coromilas J, Dwyer E, Gillespie J, Gregory J, Kleiger R, Lichstein E, Parker J, Raubertas R, Stern S, Tzivoni D, Van Voorhees L, Krasicky G, Shah R, Walroth J, Greengart A, Moriel M, Challis T, Blood D, Rolnitzky L, DePuey G, Kuller L, Odoroff C, Schwartz R, Annechiarico R, Andrews M, Severski P, Ma G, Edwards J, Fischer K, Freedland K, Cobb L, Korsten J, Williams W, Algeo S, Chandysson P. Detection and Significance of Myocardial Ischemia in Stable Patients After Recovery From an Acute Coronary Event. JAMA 1993, 269: 2379-2385. DOI: 10.1001/jama.1993.03500180071037.Peer-Reviewed Original ResearchAcute coronary eventsSymptomatic myocardial ischemiaCoronary eventsST depressionMyocardial ischemiaNoninvasive testingExercise-induced ST depressionReversible thallium-201 defectsSubsequent coronary eventsHigh-risk subsetST-segment depressionThallium-201 scintigraphyThallium-201 defectsAcute myocardial infarctionNoninvasive test resultsPrimary eventFirst primary eventsPostcoronary patientsRecent hospitalizationSegment depressionUnstable anginaAmbulatory outpatientsCohort studyStable patientsExercise durationDetection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group.
Moss A, Goldstein R, Hall W, Bigger J, Fleiss J, Greenberg H, Bodenheimer M, Krone R, Marcus F, Wackers F. Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group. JAMA 1993, 269: 2379-85. PMID: 8479063, DOI: 10.1001/jama.269.18.2379.Peer-Reviewed Original ResearchConceptsAcute coronary eventsSymptomatic myocardial ischemiaCoronary eventsST depressionMyocardial ischemiaExercise-induced ST depressionReversible thallium-201 defectsSubsequent coronary eventsHigh-risk subsetST-segment depressionThallium-201 scintigraphyThallium-201 defectsAcute myocardial infarctionNoninvasive test resultsPrimary eventFirst primary eventsNon-invasive testingPostcoronary patientsRecent hospitalizationSegment depressionUnstable anginaAmbulatory outpatientsStable patientsExercise durationLung uptake
1983
Anatomic and prognostic significance of new T-wave inversion in unstable angina
Haines D, Raabe D, Gundel W, Wackers F. Anatomic and prognostic significance of new T-wave inversion in unstable angina. The American Journal Of Cardiology 1983, 52: 14-18. PMID: 6602539, DOI: 10.1016/0002-9149(83)90061-9.Peer-Reviewed Original ResearchConceptsT-wave inversionNew T-wave inversionAnterior T-wave inversionSignificant right coronary artery diseaseRight coronary artery diseaseLeft anterior descending (LAD) arteryPositive predictive value 86Anterior descending (LAD) arteryCoronary artery diseaseSignificant LAD stenosisCoronary care unitInferior T-wave inversionsUnstable anginaArtery diseaseConsecutive patientsCoronary angiographyLAD stenosisCare unitInferior leadsSpecificity 89PatientsDiameter reductionAnginaHospitalizationStenosis
1980
Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemia
Wackers F. Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemia. Seminars In Nuclear Medicine 1980, 10: 127-145. PMID: 7394537, DOI: 10.1016/s0001-2998(80)80016-x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionPerfusion defectsThallium-201 myocardial scintigraphyThallium-201 scintigraphyOnset of symptomsResults of scintigraphyChest painUnstable anginaJeopardized myocardiumMyocardial scintigraphyPrognostic stratificationEarly recognitionHigh riskInfarctionPatientsScintigraphyIschemiaHrAnginaComplicationsPainReliable methodThallium-201 Myocardial Imaging in Unstable Agina and Variant Angina
Wackers F, Lie K, Liem K, Busemann Sokole E, van der Schoot J. Thallium-201 Myocardial Imaging in Unstable Agina and Variant Angina. Developments In Cardiovascular Medicine 1980, 9: 199-216. DOI: 10.1007/978-94-009-8904-7_10.Peer-Reviewed Original ResearchCoronary care unitAcute myocardial infarctionUnstable anginaMyocardial infarctionVariant anginaAnginal attacksCare unitScintigraphic defectsCoronary care unit admissionThallium-201 myocardial imagingCare unit admissionLow-risk patientsMajority of patientsPain-free periodUnstable angina pectorisInitial acute phaseImportant therapeutic decisionsPotential predictive valueCoronary spasmUnit admissionRisk patientsAngina pectorisAcute phasePoor prognosisTransient ischemia
1978
Thallium-201 scintigraphy in unstable angina pectoris.
Wackers F, Lie K, Liem K, Sokole E, Samson G, van der Schoot J, Durrer D. Thallium-201 scintigraphy in unstable angina pectoris. Circulation 1978, 57: 738-742. PMID: 630682, DOI: 10.1161/01.cir.57.4.738.Peer-Reviewed Original ResearchConceptsThallium-201 scintigraphyPain-free periodThallium-201 scansTransient ECG changesPositive scansAbnormal ECGUnstable anginaECG changesGroup IIUnstable angina pectorisFree periodCoronary surgeryAngina pectorisComplicated courseMaximal treatmentPatientsAnginaGroup IScintigraphyECGScansTreatmentPectorisScintiscanInfarction