2014
Predictors of Physical Inactivity in Men and Women With Type 2 Diabetes From the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
McCarthy M, Davey J, Wackers F, Chyun D. Predictors of Physical Inactivity in Men and Women With Type 2 Diabetes From the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. The Science Of Diabetes Self-Management And Care 2014, 40: 678-687. PMID: 24942531, PMCID: PMC4169341, DOI: 10.1177/0145721714540055.Peer-Reviewed Original ResearchMeSH KeywordsCanadaDiabetes Mellitus, Type 2Diabetic AngiopathiesExerciseFemaleFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedMotor ActivityMyocardial IschemiaPeripheral Nervous System DiseasesPredictive Value of TestsPrevalenceProspective StudiesRisk FactorsSedentary BehaviorTime FactorsUnited StatesConceptsAsymptomatic Diabetics (DIAD) studyPhysical inactivityType 2 diabetesDetection of ischemiaDiabetic studyOverweight/obesityPrimary care practicesPhysical activity dataGender-related differencesAsymptomatic patientsAutonomic neuropathySilent ischemiaSecondary data analysisCare practicesType 2Secondary analysisIschemiaDiabetesTime pointsInactivityBaselineWomenMenGender differencesYears
2012
THE HEART RATE RESPONSE TO ADENOSINE AS A PREDICTOR OF ADVERSE CARDIAC OUTCOMES IN THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS STUDY
Hage F, Wackers F, Bansal S, Chyun D, Young L, Inzucchi S, Iskandrian A. THE HEART RATE RESPONSE TO ADENOSINE AS A PREDICTOR OF ADVERSE CARDIAC OUTCOMES IN THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS STUDY. Journal Of The American College Of Cardiology 2012, 59: e1162. DOI: 10.1016/s0735-1097(12)61163-2.Peer-Reviewed Original Research
2011
85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing
Jain M, Nkonde C, Lin BA, Walker A, Wackers FJ. 85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing. Journal Of Nuclear Cardiology 2011, 18: 1026-1035. PMID: 21922347, DOI: 10.1007/s12350-011-9454-0.Peer-Reviewed Original ResearchConceptsMaximal age-predicted heart rateAge-predicted heart rateInducible ischemiaPeak exerciseExercise testingPositive ECGHeart rateExercise endpointPositive exercise ECGExercise treadmill testingRegistry patientsProspective registryExercise capacityRetrospective cohortTreadmill testingPatient cohortExercise ECGValid endpointPatientsMore womenEndpointIschemiaClinical laboratoriesECGCohortSCREENING ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES FOR SILENT MYOCARDIAL ISCHEMIA: IMPORTANT GENDER DIFFERENCES FROM THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS (DIAD) STUDY
Tandon S, Bansal S, Inzucchi S, Staib L, Davey J, Chyun D, Young L, Wackers F. SCREENING ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES FOR SILENT MYOCARDIAL ISCHEMIA: IMPORTANT GENDER DIFFERENCES FROM THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS (DIAD) STUDY. Journal Of The American College Of Cardiology 2011, 57: e745. DOI: 10.1016/s0735-1097(11)60745-6.Peer-Reviewed Original Research
2007
Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
Wackers FJ, Chyun DA, Young LH, Heller GV, Iskandrian AE, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE. Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. Diabetes Care 2007, 30: 2892-2898. PMID: 17682123, DOI: 10.2337/dc07-1250.Peer-Reviewed Original ResearchConceptsResolution of ischemiaType 2 diabetesDetection of ischemiaNew ischemiaAsymptomatic Diabetics (DIAD) studyCardiovascular risk factorsAsymptomatic myocardial ischemiaAdenosine stress myocardial perfusionRepeat stressIschemia increasesAsymptomatic patientsCardiac eventsMore patientsACE inhibitorsMyocardial ischemiaRisk factorsIntensive treatmentDiabetic studyIschemiaMyocardial perfusionPatientsMedical treatmentDiabetesInitial evaluationGreater increase
2006
The Impact of Screening for Asymptomatic Myocardial Ischemia in Individuals With Type 2 Diabetes
Chyun DA, Katten DM, Melkus GD, Talley S, Davey JA, Wackers FJ. The Impact of Screening for Asymptomatic Myocardial Ischemia in Individuals With Type 2 Diabetes. The Journal Of Cardiovascular Nursing 2006, 21: e1-e7. PMID: 16601520, DOI: 10.1097/00005082-200603000-00015.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAntihypertensive AgentsAnxietyAspirinDepressionDiabetes Mellitus, Type 2EmotionsFemaleFibrinolytic AgentsFollow-Up StudiesHealth BehaviorHumansHypolipidemic AgentsMaleMass ScreeningMiddle AgedMotor ActivityMultivariate AnalysisMyocardial IschemiaPersonal AutonomyProspective StudiesQuality of LifeRisk AssessmentSocioeconomic FactorsConceptsCoronary artery diseaseType 2 diabetesAsymptomatic coronary artery diseasePoor emotional outcomesAsymptomatic myocardial ischemiaRisk factor behaviorsImpact of screeningSelf-administered questionnaireAggressive screeningArtery diseaseProspective studyStudy baselineMyocardial ischemiaScreening TrialMyocardial perfusionEmotional outcomesOutcomesDiabetesBehavior outcomesLaboratory testsLow levelsScreeningHigh levelsIschemiaPerfusion
2003
Electromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy
Samady H, Liu Y, Choi CJ, Ragosta M, Pfau SE, Cleman MW, Powers ER, Kramer CM, Wackers F, Beller GA, Watson DD. Electromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy. The American Journal Of Cardiology 2003, 91: 807-811. PMID: 12667565, DOI: 10.1016/s0002-9149(03)00013-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Surface Potential MappingCardiomyopathiesCell SurvivalElectrophysiologic Techniques, CardiacFemaleHumansMaleMiddle AgedMyocardial IschemiaMyocardiumPredictive Value of TestsRadiopharmaceuticalsRestROC CurveSensitivity and SpecificitySeverity of Illness IndexStatistics as TopicStress, PhysiologicalStroke VolumeTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsSevere ischemic cardiomyopathyIschemic cardiomyopathyViable myocardiumMyocardial viabilityDipyridamole single-photon emissionUnipolar voltageDysfunctional myocardial segmentsBipolar voltageSingle photon emissionDipyridamole SPECTDipyridamole technetiumQuantitative technetiumInducible ischemiaNonviable segmentsNonviable myocardiumElectromechanical mappingMyocardial segmentsTracer uptakePatientsViable segmentsLogistic regressionCardiomyopathyMyocardiumIschemiaSPECT
1994
Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia.
Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL. Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. Journal Of Nuclear Medicine 1994, 35: 664-71. PMID: 8151391.Peer-Reviewed Original ResearchConceptsTechnetium-99mCanine modelPerfusion tracerMicrosphere flowCoronary artery occlusionInitial myocardial uptakeIntact canine modelOpen-chest dogsMyocardial perfusion imagingMyocardial blood flowDynamic planar imagingArtery occlusionPharmacological vasodilatationPharmacological stressMyocardial perfusion tracersMyocardial uptakeRadiotracer injectionBlood flowMyocardial perfusionPerfusion imagingArterial samplingMyocardial flowBackground activity ratioTetrofosminIschemia
1990
Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction
ZARET B, WACKERS F. Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction. Annals Of The New York Academy Of Sciences 1990, 601: 107-118. PMID: 2221682, DOI: 10.1111/j.1749-6632.1990.tb37296.x.Peer-Reviewed Original ResearchConceptsMyocardial perfusion scintigraphyPerfusion scintigraphyMyocardial ischemiaPresence of reperfusionChronic coronary syndromeChronic coronary diseaseChronic myocardial ischemiaSignificant Q wavesElectrocardiographic documentationCoronary syndromeCoronary diseaseElectrocardiographic changesThrombolytic therapyMyocardial infarctionLimitations of electrocardiographyPharmacologic stressPrognostic evaluationQ wavesInfarct zoneScintigraphyIschemiaInfarctionPatientsCumulative experienceReperfusion
1988
The Role of Nuclear Cardiology in Assessment of Acute Myocardial Infarction
den D, Wackers F, Zaret B. The Role of Nuclear Cardiology in Assessment of Acute Myocardial Infarction. Cardiology Clinics 1988, 6: 81-95. PMID: 3048676, DOI: 10.1016/s0733-8651(18)30503-4.Peer-Reviewed Original ResearchConceptsConvalescent phaseVentricular functionExercise-induced ischemiaAcute myocardial infarctionSalvaged myocardiumThallium imagingThrombolytic therapyAcute interventionIschemic myocardiumMyocardial infarctionPrognostic informationFurther interventionMyocardial perfusionPerfusion imagingAmbulatory monitoringMetabolic imagingMyocardiumNuclear cardiologyAppropriate management strategiesInterventionImagingInfarctionIschemiaPatientsTherapy
1985
Use of the Initial Electrocardiogram to Predict In-Hospital Complications of Acute Myocardial Infarction
Brush J, Brand D, Acampora D, Chalmer B, Wackers F. Use of the Initial Electrocardiogram to Predict In-Hospital Complications of Acute Myocardial Infarction. New England Journal Of Medicine 1985, 312: 1137-1141. PMID: 3920520, DOI: 10.1056/nejm198505023121801.Peer-Reviewed Original ResearchConceptsLife-threatening complicationsCoronary care unitAcute myocardial infarctionInitial electrocardiogramCare unitMyocardial infarctionPositive electrocardiogramIn-Hospital ComplicationsNegative initial electrocardiogramPredictors of complicationsIntermediate care unitEvidence of infarctionBundle branch blockVentricular hypertrophyNegative electrocardiogramHospital costsComplicationsPatientsPatient careInfarctionElectrocardiogramLower likelihoodIschemiaAdmissionHypertrophy
1980
Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemia
Wackers F. Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemia. Seminars In Nuclear Medicine 1980, 10: 127-145. PMID: 7394537, DOI: 10.1016/s0001-2998(80)80016-x.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionPerfusion defectsThallium-201 myocardial scintigraphyThallium-201 scintigraphyOnset of symptomsResults of scintigraphyChest painUnstable anginaJeopardized myocardiumMyocardial scintigraphyPrognostic stratificationEarly recognitionHigh riskInfarctionPatientsScintigraphyIschemiaHrAnginaComplicationsPainReliable methodThallium-201 Myocardial Imaging as a Selection Method for the Coronary Care Unit
Wackers F, Lie K, Busemann Sokole E, Samson G, van der Schoot J. Thallium-201 Myocardial Imaging as a Selection Method for the Coronary Care Unit. Developments In Cardiovascular Medicine 1980, 9: 223-235. DOI: 10.1007/978-94-009-8904-7_12.Peer-Reviewed Original ResearchCoronary care unitAcute myocardial infarctionCare unitMyocardial infarctionThallium-201 myocardial imagingCoronary artery insufficiencyInitial electrocardiogramNondiagnostic electrocardiogramQuestionable historyPatient admissionsMyocardial imagingPatientsInitial evaluationInfarctionSubstantial groupDiagnosisComplaintsElectrocardiogramSignificant numberIschemiaAdmissionHospitalEtiologyInsufficiencyFurther observationsCurrent Status of Radionuclide Imaging in the Management and Evaluation of patients with cardiovascular Disease
Wackers F. Current Status of Radionuclide Imaging in the Management and Evaluation of patients with cardiovascular Disease. Advances In Cardiology 1980, 27: 40-50. PMID: 7004129, DOI: 10.1159/000383973.Peer-Reviewed Original Research