1993
Detection and Significance of Myocardial Ischemia in Stable Patients After Recovery From an Acute Coronary Event
Moss A, Goldstein R, Hall W, Bigger J, Fleiss J, Greenberg H, Bodenheimer M, Krone R, Marcus F, Wackers F, Benhorin J, Brown M, Case R, Coromilas J, Dwyer E, Gillespie J, Gregory J, Kleiger R, Lichstein E, Parker J, Raubertas R, Stern S, Tzivoni D, Van Voorhees L, Krasicky G, Shah R, Walroth J, Greengart A, Moriel M, Challis T, Blood D, Rolnitzky L, DePuey G, Kuller L, Odoroff C, Schwartz R, Annechiarico R, Andrews M, Severski P, Ma G, Edwards J, Fischer K, Freedland K, Cobb L, Korsten J, Williams W, Algeo S, Chandysson P. Detection and Significance of Myocardial Ischemia in Stable Patients After Recovery From an Acute Coronary Event. JAMA 1993, 269: 2379-2385. DOI: 10.1001/jama.1993.03500180071037.Peer-Reviewed Original ResearchAcute coronary eventsSymptomatic myocardial ischemiaCoronary eventsST depressionMyocardial ischemiaNoninvasive testingExercise-induced ST depressionReversible thallium-201 defectsSubsequent coronary eventsHigh-risk subsetST-segment depressionThallium-201 scintigraphyThallium-201 defectsAcute myocardial infarctionNoninvasive test resultsPrimary eventFirst primary eventsPostcoronary patientsRecent hospitalizationSegment depressionUnstable anginaAmbulatory outpatientsCohort studyStable patientsExercise durationDetection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group.
Moss A, Goldstein R, Hall W, Bigger J, Fleiss J, Greenberg H, Bodenheimer M, Krone R, Marcus F, Wackers F. Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group. JAMA 1993, 269: 2379-85. PMID: 8479063, DOI: 10.1001/jama.269.18.2379.Peer-Reviewed Original ResearchConceptsAcute coronary eventsSymptomatic myocardial ischemiaCoronary eventsST depressionMyocardial ischemiaExercise-induced ST depressionReversible thallium-201 defectsSubsequent coronary eventsHigh-risk subsetST-segment depressionThallium-201 scintigraphyThallium-201 defectsAcute myocardial infarctionNoninvasive test resultsPrimary eventFirst primary eventsNon-invasive testingPostcoronary patientsRecent hospitalizationSegment depressionUnstable anginaAmbulatory outpatientsStable patientsExercise durationLung uptake
1987
Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy Seven-year experience using serial radionuclide angiocardiography
Schwartz R, McKenzie W, Alexander J, Sager P, D'Souza A, Manatunga A, Schwartz P, Berger H, Setaro J, Surkin L, Wackers F, Zaret B. Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy Seven-year experience using serial radionuclide angiocardiography. The American Journal Of Medicine 1987, 82: 1109-1118. PMID: 3605130, DOI: 10.1016/0002-9343(87)90212-9.Peer-Reviewed Original ResearchConceptsClinical congestive heart failureCongestive heart failureVentricular ejection fractionAbsolute left ventricular ejection fractionLeft ventricular ejection fractionHeart failureEjection fractionDoxorubicin therapyMild congestive heart failureClinical predictor variablesDiscontinuation of doxorubicinTotal cumulative dosageHigh-risk patientsHigh-risk subsetMajority of patientsHigh cumulative doseCommunity hospital settingProportional hazards regressionSeven-year experienceCommunity hospital environmentSerial radionuclideLast followVentricular dysfunctionClinical outcomesRoutine therapy