2006
Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer
Abu-Khalaf MM, Juneja V, Chung GG, DiGiovanna MP, Sipples R, McGurk M, Zelterman D, Haffty B, Reiss M, Wackers FJ, Lee FA, Burtness BA. Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer. Breast Cancer Research And Treatment 2006, 104: 341-349. PMID: 17051423, DOI: 10.1007/s10549-006-9413-7.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionEnd of chemotherapyEquilibrium radionuclide angiographyBreast cancerAdjuvant therapySequential doxorubicinCardiac functionIpsilateral axillary lymph nodesHigh-risk breast cancerRisk breast cancerClinical heart failureInitiation of chemotherapyAxillary lymph nodesVentricular ejection fractionEnd of therapyLong-term cardiotoxicityMedian absolute changeEligible patientsFilgrastim supportLate cardiotoxicityAxillary nodesAsymptomatic declineEjection fractionHeart failureLymph nodes
2001
Dobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy
Ramahi T, Longo M, Cadariu A, Rohlfs K, Slade M, Carolan S, Vallejo E, Wackers F. Dobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy. European Heart Journal 2001, 22: 849-856. PMID: 11350094, DOI: 10.1053/euhj.2001.2654.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionTransplant-free survivalEjection fractionHeart failureVentricular end-diastolic volume indexOverall transplant-free survivalPeak exercise oxygen consumptionSevere non-ischaemic cardiomyopathyEnd-diastolic volume indexFunctional classStrongest prognostic variableChronic heart failureHeart failure patientsPrognosis of patientsNon-ischemic cardiomyopathyExercise oxygen consumptionEquilibrium radionuclide ventriculographyVentriculographic variablesExercise capacityFailure patientsPrognostic valueRadionuclide ventriculographyIntravenous infusionDeltaLVEF
1996
Distortion of the Terminal Portion of the QRS on the Admission Electrocardiogram in Acute Myocardial Infarction and Correlation With Infarct Size and Long-Term Prognosis (Thrombolysis In Myocardial Infarction 4 Trial)**This study was supported in part by a grant from SmithKline Beecham, Philadelphia, Pennsylvania.
Birnbaum Y, Kloner R, Sclarovsky S, Cannon C, McCabe C, Davis V, Zaret B, Wackers F, Braunwald E. Distortion of the Terminal Portion of the QRS on the Admission Electrocardiogram in Acute Myocardial Infarction and Correlation With Infarct Size and Long-Term Prognosis (Thrombolysis In Myocardial Infarction 4 Trial)**This study was supported in part by a grant from SmithKline Beecham, Philadelphia, Pennsylvania. The American Journal Of Cardiology 1996, 78: 396-403. PMID: 8752182, DOI: 10.1016/s0002-9149(96)00326-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAngina PectorisCardiac Output, LowCoronary AngiographyCreatine KinaseDouble-Blind MethodElectrocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionPatient AdmissionPrognosisRecurrenceRetrospective StudiesStroke VolumeSurvival RateTechnetium Tc 99m SestamibiThrombolytic TherapyTreatment OutcomeVentricular Function, LeftConceptsAcute myocardial infarctionLong-term prognosisAnterior acute myocardial infarctionCreatine kinase releaseInfarct sizeMyocardial infarctionMyocardial infarction (TIMI) 4 trialAnterior AMI patientsOne-year mortalityCoronary angiographic findingsLarger infarct sizeVentricular ejection fractionAdmission electrocardiogramHospital mortalityPrevious anginaSestamibi defectsAngiographic findingsBaseline characteristicsEjection fractionHeart failureAMI patientsClinical outcomesQRS distortionPatientsEnd point
1989
Heterogeneous signal intensity in magnetic resonance images of hypertrophied left ventricular myocardium
Zahler R, Chelmow D, Gore J, Wilkens K, Pope C, Sostman H, Meese R, Negro-Vilar R, Herfkens R, Wackers F, Zaret B. Heterogeneous signal intensity in magnetic resonance images of hypertrophied left ventricular myocardium. Magnetic Resonance Imaging 1989, 7: 517-528. PMID: 2532699, DOI: 10.1016/0730-725x(89)90405-0.Peer-Reviewed Original ResearchConceptsLeft ventricular hypertrophyVentricular hypertrophyLeft ventricular hypertrophy patientsHypertrophy patientsMagnetic resonance imagesHuman left ventricular hypertrophyDuration of diseaseCongestive heart failureHeterogeneous signal intensityLeft ventricular myocardiumMagnetic resonance imagingResonance imagesElectrocardiographic abnormalitiesHeart failureAortic bandingPathologic changesHypertrophied myocardiumEnd-diastolic imagesVentricular myocardiumPatientsHypertrophyResonance imagingEnd-systolic imagesNormal tissuesTissue characterization algorithm
1987
Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy Seven-year experience using serial radionuclide angiocardiography
Schwartz R, McKenzie W, Alexander J, Sager P, D'Souza A, Manatunga A, Schwartz P, Berger H, Setaro J, Surkin L, Wackers F, Zaret B. Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy Seven-year experience using serial radionuclide angiocardiography. The American Journal Of Medicine 1987, 82: 1109-1118. PMID: 3605130, DOI: 10.1016/0002-9343(87)90212-9.Peer-Reviewed Original ResearchConceptsClinical congestive heart failureCongestive heart failureVentricular ejection fractionAbsolute left ventricular ejection fractionLeft ventricular ejection fractionHeart failureEjection fractionDoxorubicin therapyMild congestive heart failureClinical predictor variablesDiscontinuation of doxorubicinTotal cumulative dosageHigh-risk patientsHigh-risk subsetMajority of patientsHigh cumulative doseCommunity hospital settingProportional hazards regressionSeven-year experienceCommunity hospital environmentSerial radionuclideLast followVentricular dysfunctionClinical outcomesRoutine therapy
1983
Serial radionuclide assessment of doxorubicin cardiotoxicity in cancer patients with abnormal baseline resting left ventricular performance
Choi B, Berger H, Schwartz P, Alexander J, Wackers F, Gottschalk A, Zaret B. Serial radionuclide assessment of doxorubicin cardiotoxicity in cancer patients with abnormal baseline resting left ventricular performance. American Heart Journal 1983, 106: 638-643. PMID: 6613807, DOI: 10.1016/0002-8703(83)90080-7.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionCongestive heart failureLeft ventricular performanceVentricular performanceEjection fractionAbnormal baselineHeart failureDoxorubicin therapyDoxorubicin cardiotoxicityRadionuclide angiocardiographyAbnormal left ventricular ejection fractionFinal left ventricular ejection fractionAntecedent cardiovascular diseaseSerial radionuclide studiesFirst-pass radionuclide angiocardiographyIdentification of patientsUse of doxorubicinSafe discontinuationThoracic radiationVentricular functionCancer patientsCumulative doseCardiovascular diseaseRadionuclide assessment
1976
Coronary artery disease in patients dying from cardiogenic shock or congestive heart failure in the setting of acute myocardial infarction.
Wackers F, Lie K, Becker A, Durrer D, Wellens H. Coronary artery disease in patients dying from cardiogenic shock or congestive heart failure in the setting of acute myocardial infarction. Heart 1976, 38: 906. PMID: 971375, PMCID: PMC483104, DOI: 10.1136/hrt.38.9.906.Peer-Reviewed Original ResearchConceptsCongestive heart failureAcute myocardial infarctionHeart failureCardiogenic shockCoronary arteryMyocardial infarctionSevere diseaseFatal congestive heart failureRefractory congestive heart failurePump failureThree-vessel diseaseCoronary bypass surgeryRight coronary arteryCoronary artery diseaseLeft circumflex arteryCent narrowingBypass surgeryArtery diseaseLeft anteriorCircumflex arteryPathological findingsSevere narrowingEqual incidenceAnatomical findingsPatients
1975
Extent and severity of coronary artery disease in patients dying from cardiogenic shock or congestive heart failure following acute myocardial infarction
Wackers F, Lie K, Becker A, Wellens H, Durrer D. Extent and severity of coronary artery disease in patients dying from cardiogenic shock or congestive heart failure following acute myocardial infarction. The American Journal Of Cardiology 1975, 35: 175. DOI: 10.1016/0002-9149(75)90805-x.Peer-Reviewed Original Research