Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy Seven-year experience using serial radionuclide angiocardiography
Schwartz R, McKenzie W, Alexander J, Sager P, D'Souza A, Manatunga A, Schwartz P, Berger H, Setaro J, Surkin L, Wackers F, Zaret B. Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy Seven-year experience using serial radionuclide angiocardiography. The American Journal Of Medicine 1987, 82: 1109-1118. PMID: 3605130, DOI: 10.1016/0002-9343(87)90212-9.Peer-Reviewed Original ResearchConceptsClinical congestive heart failureCongestive heart failureVentricular ejection fractionAbsolute left ventricular ejection fractionLeft ventricular ejection fractionHeart failureEjection fractionDoxorubicin therapyMild congestive heart failureClinical predictor variablesDiscontinuation of doxorubicinTotal cumulative dosageHigh-risk patientsHigh-risk subsetMajority of patientsHigh cumulative doseCommunity hospital settingProportional hazards regressionSeven-year experienceCommunity hospital environmentSerial radionuclideLast followVentricular dysfunctionClinical outcomesRoutine therapy