1986
Effects of Cyclosporine and Cortisone on the Pathogenesis of Primary Infection with Cytomegalovirus in the Guinea Pig
MacGregor M, Lucia H, Vine W, FitzGerald P, Bia F. Effects of Cyclosporine and Cortisone on the Pathogenesis of Primary Infection with Cytomegalovirus in the Guinea Pig. The Journal Of Infectious Diseases 1986, 153: 503-510. PMID: 3005426, DOI: 10.1093/infdis/153.3.503.Peer-Reviewed Original ResearchConceptsPrimary infectionGuinea pigsTissue culture infectious dosesEffect of cyclosporineGuinea pig modelRate of isolationGuinea pig cytomegalovirusOral CsAImmunosuppressive agentsInflammatory responseInfectious dosesViral inclusionsPig modelDay 14Day 0CortisoneCytomegalovirusMinimal inflammatory responseCsALymphopeniaPathogenesisInfectionUntreated controlsAnimalsTissue
1983
Cytomegaloviral Infections in the Guinea Pig: Experimental Models for Human Disease
Bia F, Griffith B, Fong C, Hsiung G. Cytomegaloviral Infections in the Guinea Pig: Experimental Models for Human Disease. Clinical Infectious Diseases 1983, 5: 177-195. PMID: 6302812, DOI: 10.1093/clinids/5.2.177.Peer-Reviewed Original ResearchConceptsGuinea pig cytomegalovirusInterstitial pneumoniaTransplacental transmissionGuinea pigsPrimary CMV infectionPolymorphonuclear leukocyte functionGuinea pig modelSalivary gland virusHuman viral infectionsCongenital infectionCytomegaloviral infectionCMV infectionBlood transfusionFungal superinfectionsViremic infectionAntigen vaccineTransmission of virusesSuch vaccinesLeukocyte functionHuman diseasesCocultivation techniquesViral infectionPig modelCytomegalovirusInfectious diseases
1982
Effects of Vaccination on Cytomegalovirus-Associated Interstitial Pneumonia in Strain 2 Guinea Pigs
Bia F, Lucia H, Fong C, Tarsio M, Hsiung G. Effects of Vaccination on Cytomegalovirus-Associated Interstitial Pneumonia in Strain 2 Guinea Pigs. The Journal Of Infectious Diseases 1982, 145: 742-747. PMID: 6281341, DOI: 10.1093/infdis/145.2.742.Peer-Reviewed Original ResearchConceptsStrain 2 guinea pigsInterstitial pneumoniaCMV infectionGuinea pigsMinimal histopathologic changesTissue culture infective dosesBilateral interstitial pneumoniaEffect of vaccinationStudy of pathogenesisGuinea pig cytomegalovirusHistologic evidenceHistopathologic changesPneumoniaVaccinated animalsInfective dosesCytomegalovirusInfectionLungInfected tissuesPathogenesisPigsTissuePreventionAnimalsViremiaNeutrophil response and function during acute cytomegalovirus infection in guinea pigs
Yourtee E, Bia F, Griffith B, Root R. Neutrophil response and function during acute cytomegalovirus infection in guinea pigs. Infection And Immunity 1982, 36: 11-16. PMID: 6281184, PMCID: PMC351177, DOI: 10.1128/iai.36.1.11-16.1982.Peer-Reviewed Original ResearchConceptsAcute cytomegalovirus infectionTissue culture infective dosesCytomegalovirus infectionPolymorphonuclear leukocytesGuinea pig cytomegalovirusPeritoneal polymorphonuclear leukocytesGuinea pigsInfected animalsInflammatory stimuliUninfected controlsInfective dosesHartley strain guinea pigsType of infectionPhorbol myristate acetateAcute infectionGranulocyte numbersNeutrophil responseCasein injectionNeutrophil activatorInflammatory sitesBacterial stimuliControl animalsBone marrowDecreased mobilizationBacterial killing
1980
Vaccination for the Prevention of Maternal and Fetal Infection with Guinea Pig Cytomegalovirus
Bia F, Griffith B, Tarsio M, Hsiung G. Vaccination for the Prevention of Maternal and Fetal Infection with Guinea Pig Cytomegalovirus. The Journal Of Infectious Diseases 1980, 142: 732-738. PMID: 6257798, DOI: 10.1093/infdis/142.5.732.Peer-Reviewed Original ResearchConceptsFetal infectionAcute viremiaPregnant animalsGuinea pigsGuinea pig cytomegalovirusCMV vaccineAntigen vaccineNonimmune controlsCytomegalovirus vaccineLower incidenceControl animalsImmunized animalsVaccinated animalsCMVViremiaVaccineVirulent virusInfectionSerial passageAnimalsPigsDense bodiesTissue cultureVaccinationCytomegalovirusNew endogenous herpesvirus of guinea pigs: biological and molecular characterization
Bia F, Summers W, Fong C, Hsiung G. New endogenous herpesvirus of guinea pigs: biological and molecular characterization. Journal Of Virology 1980, 36: 245-253. PMID: 6255209, PMCID: PMC353635, DOI: 10.1128/jvi.36.1.245-253.1980.Peer-Reviewed Original ResearchConceptsGuinea pig herpes-like virusGuinea pig cytomegalovirusGuinea pigsStrain 2 guinea pigsCharacteristic cytopathic effectViral DNACross-neutralization testsVirus-infected cellsGuinea pig cellsRestriction endonuclease cleavage analysisCytopathic effectHerpes-like virusPig cellsHerpesvirusFibroblastic cellsPigsImmunoferritin electron microscopyVirusDistinct patternsCellsEndogenous herpesvirusesMolecular characterizationCytomegalovirusLeukocytesUltrastructural development and persistence of guinea pig cytomegalovirus in duct cells of guinea pig submaxillary gland
Fong C, Bia F, Hsiung G. Ultrastructural development and persistence of guinea pig cytomegalovirus in duct cells of guinea pig submaxillary gland. Archives Of Virology 1980, 64: 97-108. PMID: 6247997, DOI: 10.1007/bf01318013.Peer-Reviewed Original Research
1979
Ultrastructural Development of Guinea Pig Cytomegalovirus in Cultured Guinea Pig Embryo Cells
Fong C, Bia F, Hsiung G, Madore P, Chang P. Ultrastructural Development of Guinea Pig Cytomegalovirus in Cultured Guinea Pig Embryo Cells. Journal Of General Virology 1979, 42: 127-140. PMID: 215704, DOI: 10.1099/0022-1317-42-1-127.Peer-Reviewed Original ResearchConceptsGuinea pig cytomegalovirusUltrastructural developmentInner nuclear membraneNucleus of virusEmbryo cellsVirus capsidNuclear poresDense bodiesCytoplasmic membraneNuclear membraneImmunoelectron microscopyCytoplasmVirus nucleocapsidsCapsidNucleocapsidsVirionsCellsCultured guinea pig embryo (GPE) cellsMembraneGuinea pig embryo cellsNucleusSimilar mannerIntranuclear inclusionsTubular structures