2023
Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox modelDoes This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentation
2022
Prevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis
Nugent JT, Young C, Funaro MC, Jiang K, Saran I, Ghazi L, Wilson FP, Greenberg JH. Prevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis. The Journal Of Pediatrics 2022, 244: 30-37.e10. PMID: 35120981, PMCID: PMC9086113, DOI: 10.1016/j.jpeds.2022.01.047.Peer-Reviewed Original ResearchConceptsSecondary hypertensionPrimary careLow prevalenceNew diagnosisTime of diagnosisClinical practice guidelinesCochrane Library databasesBlood pressure deviceSignificant subgroup differencesParticipants' age rangeWeb of ScienceHypertension definitionReferral clinicProspective studyRetrospective studyOutpatient settingHealthy childrenSecondary causesCurrent guidelinesDiagnostic evaluationHypertensionObservational studyPractice guidelinesLibrary databasesPrevalence estimates
2020
A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children
Sandokji I, Yamamoto Y, Biswas A, Arora T, Ugwuowo U, Simonov M, Saran I, Martin M, Testani JM, Mansour S, Moledina DG, Greenberg JH, Wilson FP. A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children. Journal Of The American Society Of Nephrology 2020, 31: 1348-1357. PMID: 32381598, PMCID: PMC7269342, DOI: 10.1681/asn.2019070745.Peer-Reviewed Original ResearchConceptsExternal validation cohortValidation cohortElectronic health recordsSevere AKIClinical risk stratification toolDevelopment of AKIHealth recordsRisk stratification toolInternal validation cohortLength of stayCharacteristic curveElectronic medical recordsNeonatal AKIInpatient mortalitySecondary outcomesHospital admissionPrimary outcomeHospitalized childrenCreatinine valuesMedical recordsStudy populationAKICohortChildrenPredictive variables
2018
Biomarkers of AKI Progression after Pediatric Cardiac Surgery
Greenberg JH, Zappitelli M, Jia Y, Thiessen-Philbrook HR, de Fontnouvelle CA, Wilson FP, Coca S, Devarajan P, Parikh CR. Biomarkers of AKI Progression after Pediatric Cardiac Surgery. Journal Of The American Society Of Nephrology 2018, 29: 1549-1556. PMID: 29472416, PMCID: PMC5967766, DOI: 10.1681/asn.2017090989.Peer-Reviewed Original ResearchConceptsAKI progressionOptimism-corrected areaIL-8First dayStage 3 AKIUrine L-FABPProspective cohort studyBiomarkers of inflammationPediatric cardiac surgeryConfidence intervalsAKI stagePostoperative AKIKidney injuryCohort studySerum creatinineCardiac surgeryCardiopulmonary bypassTherapeutic trialsUrine biomarkersAdverse outcomesHospitalized childrenPlasma biomarkersClinical careAdditional cohortAKI