2020
Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones
Simonov M, Abel EA, Skanderson M, Masoud A, Hauser RG, Brandt CA, Wilson FP, Laine L. Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones. Clinical Gastroenterology And Hepatology 2020, 19: 72-79.e21. PMID: 32147588, PMCID: PMC7483196, DOI: 10.1016/j.cgh.2020.02.053.Peer-Reviewed Original ResearchConceptsProton pump inhibitorsPPI useKidney stonesCohort studyLevothyroxine useTime-varying Cox proportional hazardsHistamine-2 receptor antagonistsPropensity score-matched subsetIncident kidney stonesUrinary ion concentrationsLarge cohort studyCox proportional hazardsPropensity matching analysisDose-dependent increaseNegative control exposureH2RA usePPI usersMost patientsPPI usageAcid suppressionAdjusted analysisMedication usageRetrospective studyPump inhibitorsUnadjusted analyses
2012
Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality
Wilson FP, Sheehan JM, Mariani LH, Berns JS. Creatinine generation is reduced in patients requiring continuous venovenous hemodialysis and independently predicts mortality. Nephrology Dialysis Transplantation 2012, 27: 4088-4094. PMID: 22273668, PMCID: PMC3529547, DOI: 10.1093/ndt/gfr809.Peer-Reviewed Original ResearchConceptsAcute kidney injuryCreatinine generation rateContinuous venovenous hemodialysisSeverity of AKISerum creatinine concentrationCreatinine concentrationHospital mortalityTertiary care hospital settingSerum creatinine increaseGlomerular filtration rateLength of hospitalizationMeasures of severityAKI severityCreatinine increaseKidney injuryHospital dischargeMultivariable adjustmentSerum creatinineCohort studyMultivariable analysisPatient populationUnadjusted analysesCreatinine generationFiltration rateOncologic diagnosis