2016
Tissue engineering advances in spine surgery
Makhni MC, Caldwell JM, Saifi C, Fischer CR, Lehman RA, Lenke LG, Lee FY. Tissue engineering advances in spine surgery. Regenerative Medicine 2016, 11: 211-222. PMID: 26877156, DOI: 10.2217/rme.16.3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomimetic MaterialsBone and BonesBone Morphogenetic ProteinsHumansIntervertebral DiscMesenchymal Stem CellsSpineTissue EngineeringTissue ScaffoldsConceptsTissue-engineered bone graftsBiomimetic 3D scaffoldsTissue-engineered constructsBone graftTissue engineering advancesDonor site painNanoscale technologiesSite painEngineering advancesHematoma formationVascular injurySpine surgeryBone graftingBone allograftSurgery applicationsMesenchymal stem cellsTissue graftViable boneIntervertebral disc regeneration strategiesHuman tissue graftsGraftGold standardOsteoinductive capabilityDisease transmissionOwn disadvantages
2014
A Review of Osteocyte Function and the Emerging Importance of Sclerostin
Compton JT, Lee FY. A Review of Osteocyte Function and the Emerging Importance of Sclerostin. Journal Of Bone And Joint Surgery 2014, 96: 1659-1668. PMID: 25274791, PMCID: PMC4179450, DOI: 10.2106/jbjs.m.01096.Peer-Reviewed Original ResearchConceptsBone massPhase III clinical trialsMetastatic bone diseaseOsteoporosis-related fracturesBone mineral densityBone cellsExtensive dendritic networkNormal physiologic stateSclerostin actsParathyroid hormoneInflammatory moleculesBone metabolismClinical trialsMineral densityProstaglandin E2Bone diseaseSystemic circulationOrthopedic conditionsProtein sclerostinOsseous integrationSclerostinBone cell populationsPhysiologic stateCell populationsOsteocyte function
2006
TREATMENT OF CONGENITAL PSEUDARTHROSIS OF THE TIBIA WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-7 (RHBMP-7)
LEE FY, SINICROPI SM, LEE FS, VITALE MG, ROYE DP, CHOI IH. TREATMENT OF CONGENITAL PSEUDARTHROSIS OF THE TIBIA WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-7 (RHBMP-7). Journal Of Bone And Joint Surgery 2006, 88: 627-633. DOI: 10.2106/00004623-200603000-00023.Peer-Reviewed Original ResearchTreatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7)
Lee F, Sinicropi S, Lee F, Vitale M, Roye D, Choi I. Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7). Journal Of Bone And Joint Surgery 2006, 88: 627-633. PMID: 16510831, DOI: 10.2106/jbjs.d.02201.Peer-Reviewed Original Research
2004
Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP).
Delloye C, Suratwala SJ, Cornu O, Lee FY. Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP). Acta Orthopaedica Belgica 2004, 70: 591-7. PMID: 15669462.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone Morphogenetic ProteinsBone NeoplasmsBone TransplantationFemaleFollow-Up StudiesFractures, UnunitedHumansMaleMiddle AgedOsteosarcomaRadiographyRetrospective StudiesRisk AssessmentSampling StudiesSarcoma, EwingSensitivity and SpecificityTransplantation, HomologousTreatment OutcomeConceptsAllograft-host junctionAllograft nonunionRecombinant human bone morphogenetic proteinAllograft fractureIntercalary allograftsFracture nonunionHuman bone morphogenetic proteinAdditional radiation therapyMalignant bone tumorsRhBMP-7Allograft bone transplantationBone morphogenetic proteinAdjuvant chemotherapySterile drainageRadiological evidenceCorticocancellous allograftFemoral allograftsTibial nonunionWide resectionOsteoarticular allograftsTumor recurrenceMain complicationsNonunion siteBone tumorsRadiation therapy
2002
Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2
Lee FY, Storer S, Hazan EJ, Gebhardt MC, Mankin HJ. Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2. Clinical Orthopaedics And Related Research® 2002, 397: 119-126. PMID: 11953604, DOI: 10.1097/00003086-200204000-00017.Peer-Reviewed Original ResearchConceptsAllograft fractureNormal fracture healingFracture healingProtein 2Long-term clinical dataExtensive tumour surgeryBone morphogenetic protein-2Major revision surgeryMorphogenetic protein-2Experimental groupOnly fibrosisRadiographic unionNew bone formationRevision surgeryAdditional ratsClinical dataTumor surgeryBone allograftAllograft boneControl groupBiologic regulatorsOsteotomy siteFracture repairRecombinant human bone morphogenetic protein-2Adequate function